Protein Alignment tbc and sgsm1

DIOPT Version :9

• Sequence 1: NP_001285494.1
• Gene: tbc / 318059
• FlyBaseID: FBgn0052506
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001106422.2
• Gene: sgsm1 / 100127590
• XenbaseID: XB-GENE-6043600
• Length: 1096
• Species: Xenopus tropicalis
• Alignment Length: 1239
• Identity: 560/1239 - (45%)
• Similarity: 736/1239 - (59%)
• Gaps: 227/1239 - (18%)

  Fly     1 MVQGNADGSDYKERLIASVKKEVKQLMEEAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGL 65
            |..|.|: :|.:::|:.:|||||||:||||||:|:|||:||.:.|.|.|||||:..||:|||.|.
 Frog     1 MATGTAE-ADTRQKLLKTVKKEVKQIMEEAVTRKFVHEDSSHIISFCAAVEACVLYGLKRRAAGF 64

  Fly    66 FKTSSTTALLHKIAKSCPEAEHISKLVQEIEASDPSKRSSSSSDSFQRPPMLKKSSSNSMSTGTN 130
            .:::...||..|:|||.|.||.:.:.||::|                   .|.::..|.|
 Frog    65 LRSNKIAALFMKVAKSFPLAEELCRKVQDLE-------------------QLLENKRNQM----- 105

  Fly   131 AAASTSSASASISVSASTSSMSLASMKYLWIRLALYEKRLTKIIEYLVSNASSFYDRDSLVADSD 195
                 .....|:..:....::|..::|:||||.||.||.|.||:.|||.|.:.:|::::|:.|..
 Frog   106 -----QGVQESVRKAQKLPNLSPQAIKHLWIRTALIEKVLDKIVLYLVENCNKYYEKEALLMDPV 165

  Fly   196 YGSILSSLLVGPCALEFTRAKTADHYWTDPHADELVQRHRI--SSCRRSSSTCSRPAIINFKRSL 258
            .|.||:||||||||||:|:.|||||:||||.||||||||||  |.||:.|.| .|||:...||..
 Frog   166 DGPILASLLVGPCALEYTKMKTADHFWTDPSADELVQRHRIHSSHCRQDSPT-KRPALCIQKRHS 229

  Fly   259 NTSSDEAGTGSFKSIASASVAKDYVESLHQNAKATLLYGKNNVQVLPKDVAEPMPGYLSLHQHIQ 323
            :.|.|:..:.|         |:|||||||||::||||:|||||.|.|:|..|.:||||||||...
 Frog   230 SGSMDDRPSMS---------ARDYVESLHQNSRATLLFGKNNVMVQPRDDMEAIPGYLSLHQSAD 285

  Fly   324 TLTIKWTPNQLMNGYTEAEEAEDID--KDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQ 386
            |:|:||||||||||     ...|:|  |..:|.||:.|.::||||:||||.  .||||||:||.|
 Frog   286 TMTLKWTPNQLMNG-----SVGDLDYEKSVYWDYAMTIRLEEIVYLHCHQQ--VDSGGTVVLVSQ 343

  Fly   387 DGVQRPPIHFPEGGHMQQFLSCLETGLLPHGQLDPPLWSQRGIGKMFLWPRSMRRRILPSVMESV 451
            ||:||||:.||.|||:.|||||||.|||||||||||||||||.||:|  |: :|:|......||.
 Frog   344 DGIQRPPLRFPRGGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKVF--PK-LRKRSPQGSSESA 405

  Fly   452 ----DETPIDYVFRIVSKSRHEEFAATHSILD--------FVRSTPRRAQLSSCSTTGSSD---- 500
                ::...||||||:......||.| ..::|        ..:.:.|::..||||.:||||
 Frog   406 SDKEEDEATDYVFRIIYPGSQCEFVA-QELIDPQGGGLPSMWQPSTRKSSCSSCSQSGSSDGGPS 469

  Fly   501 --CSNKSLSIDQFPMESPLILQQQQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHL 563
              |:::         .:||                    :|:|..|:.||:||||||||||||||
 Frog   470 NGCNHE---------RAPL--------------------KMLCDNMKYQIVSRAFYGWLAYCRHL 505

  Fly   564 STVRTHLSGLVHGRIT-PEMKADEE-GLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEV 626
            ||||||||.||:.:|. |::..|.. |||...||....:.......|..||:|:||:|.|:|:||
 Frog   506 STVRTHLSALVNHKIVYPDVPVDASFGLTVAIWQKYLEDSKSYEEQELLRLIYYGGIQHEIRREV 570

  Fly   627 WPYLLGHYAFGSTTEDRKKQDETCKHYYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSN--- 688
            ||:|||||.||.|.|||::.||..:..||.||:|||..:|||:|||||..|.|:.|.|||::
 Frog   571 WPFLLGHYQFGMTEEDRREVDEQIRACYEQTMAEWLGCEAIVRQREKESHAAALLKCSSGASLDI 635

  Fly   689 -----SGNDRTV-------------RAADLEAGGDLENEVFEDISDISDPGDLEFDEQQQQQQQQ 735
                 ...|.||             ..|.|::......:|||.:            |:.:|.:.:
 Frog   636 QIQRMMHRDSTVSNESSQSCSSDRQNHARLQSDSSSSTQVFESV------------EEAEQIEAR 688

  Fly   736 AE----------------CAVSGNHLTVKPIPRAMKTSTDSGHVDESFNELDEPDEEDNKQ---- 780
            :|                |:....|      |.:...|..||:.::||:..|....|.||.
 Frog   689 SEDSKPTKISNGTVANGTCSPDSGH------PSSRNFSITSGYSEQSFSTDDNASLETNKNSLYL 747

  Fly   781 ---------KQQQDEKISESESKLPDYRKLEEQINQEPSCSASTASSYETVGPGEVHQRPNSDTR 836
                     |:|....|...|:|..:...:::.::.|.:.:.|.                 .|..
 Frog   748 HMKQGTAEVKKQATSDIILPENKTAEVLPIQDSLDGEVTANESL-----------------DDFL 795

  Fly   837 SVLSPEYLSADDLQLPDDEDAVRPPPPPAAAAVIITKASVDITNWERSPKAAEGDQMSPLEEQAG 901
            |:..    |.||| |||.|.||               .|| :..|..|  .||.:.:...|:...
 Frog   796 SITE----STDDL-LPDKETAV---------------LSV-VETWPDS--EAEKESLVGSEDNLS 837

  Fly   902 ESGGAGVNMDALQQPK---------SAC-ASPASSNGGVYSSELLEQFGLNLHRIEKDVQRCDRN 956
            |.    ..|::| .|:         :.| .||.||.|..||.|||:.:.:|||||||||||||||
 Frog   838 EE----PEMESL-YPQLDSLVVIDATVCEMSPVSSTGVTYSQELLDMYTINLHRIEKDVQRCDRN 897

  Fly   957 YWYFANENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKLMERMIENFP 1021
            ||||...||:|||||:.:|||:|:::||:||||||:||||||.|||:.::|||.:||:||.:|||
 Frog   898 YWYFTPANLEKLRNVMCSYVWQHIEIGYVQGMCDLLAPLLVILDDEAKAFSCFTELMKRMNQNFP 962

  Fly  1022 SGGAMDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWA 1086
            .|||||.|||||||||||||||:::||..||||||||||||||||||||||||||||:.||.|||
 Frog   963 HGGAMDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFKRELVYDDVFSVWETIWA 1027

  Fly  1087 AKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQLQMI 1151
            ||||:|.|||||:||||:|.||||||.|:|||||:||||||||||||.:.:|:||:.||.::|.:
 Frog  1028 AKHISSAHFVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNIKHILKLAQDLVYKVQTL 1092

  Fly  1152 IENK 1155
            ||||
 Frog  1093 IENK 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tbc	NP_001285494.1	RUN	45..218	CDD:280855	64/172 (37%)
		PH_RUTBC	292..466	CDD:275431	106/179 (59%)
		TBC	923..1087	CDD:214540	120/163 (74%)
sgsm1	NP_001106422.2	RUN	44..186	CDD:367169	63/170 (37%)
		PH_RUTBC	254..424	CDD:275431	106/179 (59%)
		TBC	872..1053	CDD:214540	136/180 (76%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	299	1.000	Domainoid score	I1424
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	958	1.000	Inparanoid score	I332
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D171826at2759
OrthoFinder	1	1.000	-	-		FOG0002045
OrthoInspector	1	1.000	-	-		mtm9377
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1347
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060