DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32483 and Scpep1

DIOPT Version :9

Sequence 1:	NP_728540.1	Gene:	CG32483 / 318050	FlyBaseID:	FBgn0052483	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_083299.3	Gene:	Scpep1 / 74617	MGIID:	1921867	Length:	452	Species:	Mus musculus

Alignment Length:	441	Identity:	169/441 - (38%)
Similarity:	253/441 - (57%)	Gaps:	34/441 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 IRLVALLALF-------AALAHGKPGYGPGEQDWGYVDVRPGAHMFYWLYYTTANVSSYTERPLA 60
            :||..||..|       :|:...:|   .|::.|.||.||..||||:||||.|....:::|.||.
Mouse    10 VRLWLLLLSFLLGFSAGSAIDWREP---EGKEVWDYVTVRKDAHMFWWLYYATNPCKNFSELPLV 71

  Fly    61 IWLQGGPGASSTGYGNFEELGPVDLYGDWRSWTWVKDMNVLFIDNPVGSGFSYVDNTAFYTATNK 125
            :|||||||.||||:|||||:||:|.....|:.||::..::||:|||||:|||||:.|..|.....
Mouse    72 MWLQGGPGGSSTGFGNFEEIGPLDTQLKPRNTTWLQWASLLFVDNPVGTGFSYVNTTDAYAKDLD 136

  Fly   126 EIALDLVELMKGFYTLHPEFEEVPLHIFCESYGGKMAPEFALELYYAKKRGEVKSNLTSVALGDP 190
            .:|.|::.|:|.|:..|.||:.||.:||.||||||||...::|||.|.::|.:|.|.:.|||||.
Mouse   137 TVASDMMVLLKSFFDCHKEFQTVPFYIFSESYGGKMAAGISVELYKAVQQGTIKCNFSGVALGDS 201

  Fly   191 WTSPIDSVLAWGPFLREMGIVDHAGYNAIQEAANFTAQLVEEERWIQATYQWGNTQWEVMKASKG 255
            |.||:||||:|||:|..|.::|:.|...:.:.|......|.:..:.:||..||..:..:.|.:.|
Mouse   202 WISPVDSVLSWGPYLYSMSLLDNQGLAEVSDIAEQVLDAVNKGFYKEATQLWGKAEMIIEKNTDG 266

  Fly   256 VDFYNVLKETKGGLYQRSKALTSEERLYRT----MVKYDIDEDRTKLLEDLMRGPVAETLG-IPS 315
            |:|||:|.::     ...||:.|.....|:    :.:..:...:...|..||.||:.:.|. ||.
Mouse   267 VNFYNILTKS-----SPEKAMESSLEFLRSPLVRLCQRHVRHLQGDALSQLMNGPIKKKLKIIPE 326

  Fly   316 NVIWGSQSGTTFDIHRTDFMKPVIHIVNELLEKTPLKVGVFSGGLDLICATPGTVNWIAKLDWSR 380
            ::.||:|:...|.....|||||.|.:|::|| ...:.|.|::|.||||..|.|..:|:.||.|.:
Mouse   327 DISWGAQASYVFLSMEGDFMKPAIDVVDKLL-AAGVNVTVYNGQLDLIVDTIGQESWVQKLKWPQ 390

  Fly   381 KDEY--------LAAPRNGITVDRILEGYQKTGGNFTMFWINRSGHMAPAD 423
            ..::        ...|::..|.     .:.|:..|...:||.::|||.|:|
Mouse   391 LSKFNQLKWKALYTDPKSSETA-----AFVKSYENLAFYWILKAGHMVPSD 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32483	NP_728540.1	Peptidase_S10	18..437	CDD:298660	163/419 (39%)
Scpep1	NP_083299.3	Peptidase_S10	34..451	CDD:278857	163/417 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847361
Domainoid	1	1.000	312	1.000	Domainoid score	I1308
eggNOG	1	0.900	-	-		E1_COG2939
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41443
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2499
Isobase	1	0.950	-	0	Normalized mean entropy	S2406
OMA	1	1.010	-	-		QHG54069
OrthoDB	1	1.010	-	-		D274674at33208
OrthoFinder	1	1.000	-	-		FOG0003531
OrthoInspector	1	1.000	-	-		otm42637
orthoMCL	1	0.900	-	-		OOG6_105329
Panther	1	1.100	-	-	LDO	PTHR11802
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R172
SonicParanoid	1	1.000	-	-		X2409
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750