DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32483 and CTSA

DIOPT Version :9

Sequence 1:	NP_728540.1	Gene:	CG32483 / 318050	FlyBaseID:	FBgn0052483	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001161066.1	Gene:	CTSA / 5476	HGNCID:	9251	Length:	481	Species:	Homo sapiens

Alignment Length:	496	Identity:	113/496 - (22%)
Similarity:	191/496 - (38%)	Gaps:	118/496 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LVALLALFAALAHGKPGYG-----PG-------EQDWGYVDVRPGAHMFYWLYYTTANVSSYTER 57
            |:.||..:|:.....|...     ||       .|..||:......|:.||...:..:..:   .
Human    33 LLLLLVSWASRGEAAPDQDEIQRLPGLAKQPSFRQYSGYLKGSGSKHLHYWFVESQKDPEN---S 94

  Fly    58 PLAIWLQGGPGASSTGYGNFEELGPVDLYGDWRSWTWVKDMNVLFIDNPVGSGFSYVDNTAFYTA 122
            |:.:||.||||.||.. |...|.||..:            .|||::::|.|.||||.|: .||..
Human    95 PVVLWLNGGPGCSSLD-GLLTEHGPFLI------------ANVLYLESPAGVGFSYSDD-KFYAT 145

  Fly   123 TNKEIALDLVELMKGFYTLHPEFEEVPLHIFCESYGGKMAPEFALELYYAKKRGEVKSNLTSVAL 187
            .:.|:|....|.::.|:.|.||::...|.:..|||.|...|..|:.:..     :...||..:|:
Human   146 NDTEVAQSNFEALQDFFRLFPEYKNNKLFLTGESYAGIYIPTLAVLVMQ-----DPSMNLQGLAV 205

  Fly   188 GDPWTS--PIDSVLAWGPFLREMGIVDHAGYNAI------QEAANF--------TAQLVEEERWI 236
            |:..:|  ..|:.|.:  |....|::.:..::::      |...||        ...|.|..|.:
Human   206 GNGLSSYEQNDNSLVY--FAYYHGLLGNRLWSSLQTHCCSQNKCNFYDNKDLECVTNLQEVARIV 268

  Fly   237 QATYQWGNTQWEVMKASKGVDFYNVLKETKGGL-----YQRSKALTSE---------------ER 281
                  ||:         |::.||:.....||:     |::...:..:               :.
Human   269 ------GNS---------GLNIYNLYAPCAGGVPSHFRYEKDTVVVQDLGNIFTRLPLKRMWHQA 318

  Fly   282 LYRT--MVKYDIDEDRTKLLEDLMRGP-VAETLGIPS--------NVIWGSQSGTTFDIHRTDFM 335
            |.|:  .|:.|.....|......:..| |.:.|.||.        |.:...|....:....:.::
Human   319 LLRSGDKVRMDPPCTNTTAASTYLNNPYVRKALNIPEQLPQWDMCNFLVNLQYRRLYRSMNSQYL 383

  Fly   336 KPVIHIVNELLEKTPLKVGVFSGGLDLICATPGTVNWIAKLDWSRKDEYLAAP---RNGITVDRI 397
            |        ||.....::.:::|.:|:.|...|...::..|  ::|.|....|   :.|.:.::|
Human   384 K--------LLSSQKYQILLYNGDVDMACNFMGDEWFVDSL--NQKMEVQRRPWLVKYGDSGEQI 438

  Fly   398 LEGYQKTGGNFTMFWINRSGHMAPADNPAAMSHVLREFTSF 438
             .|:.|...:.....|..:|||.|.|.|      |..||.|
Human   439 -AGFVKEFSHIAFLTIKGAGHMVPTDKP------LAAFTMF 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32483	NP_728540.1	Peptidase_S10	18..437	CDD:298660	107/480 (22%)
CTSA	NP_001161066.1	Peptidase_S10	57..477	CDD:278857	108/472 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R172
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940