DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl14 and eva1c

DIOPT Version :9

Sequence 1:	NP_728509.1	Gene:	mthl14 / 318046	FlyBaseID:	FBgn0052476	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_009303778.2	Gene:	eva1c / 564385	ZFINID:	ZDB-GENE-091204-329	Length:	439	Species:	Danio rerio

Alignment Length:	292	Identity:	48/292 - (16%)
Similarity:	92/292 - (31%)	Gaps:	88/292 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 VLDASIHSTLVVPQTYSTEAATISGAR-----------FATSVPVQSPVDNPLDPADCS---QRE 103
            :|....|||:.:...:..::.|:.|..           .:.|..:|..:.......||.   ..:
Zfish    59 ILKCPRHSTITIQSAFYGQSETLVGLEPRMRCQWHNHSCSASTTLQKVLSECQGHRDCQFLVNHQ 123

  Fly   104 KYRKQP----------------------VATPSSRLRKCCPHGENLNIY-----RENQSDSMCD- 140
            .:.|.|                      |.....||...|.:.:.||||     |..:.:.:|.
Zfish   124 VFGKDPCPGIPKYINVSYRCKPTEHKRKVTCEGDRLLLHCKYPKVLNIYSAVYGRLLEEEDLCSS 188

  Fly   141 -----------NGLLSFEPTIISAVLF--DNCIEDLEVETTLDYDIGNPCNS------SLLYDDK 186
                       :|.:.    ::|.:.:  ..|:..::.:...|     ||..      ::||...
Zfish   189 EEQKPPYECLHHGAVD----VVSNICYGKQRCLFTVDQKHFKD-----PCPPGTKKYITILYACV 244

  Fly   187 DDVFFVLQDGSLLIIDKFGNESYTVKEHYCLDIDK--------SGHLFAFTCVTQVEEQIAFAKV 243
            ........|.|..:.....::|....|...:...|        |..|..|..:|:..|
Zfish   245 PQSLLKEADPSSFLTTSMPSQSTKEAERPVIRSSKFPEGGIILSNALMGFGYITEHPE------- 302

  Fly   244 VFVAVLMLISMPCL-LLVSYLHMTLRLLRNLH 274
              :|.|:..|..|: ||:..:.::.:|..:.|
Zfish   303 --MAGLLFTSSVCVGLLIVLIAVSTQLTCSRH 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl14	NP_728509.1	7tmB3_Methuselah-like	239..512	CDD:320167	8/37 (22%)
		TM helix 1	241..266	CDD:320167	6/25 (24%)
		TM helix 2	275..297	CDD:320167	48/292 (16%)
		TM helix 3	306..331	CDD:320167
		TM helix 4	349..369	CDD:320167
		TM helix 5	389..418	CDD:320167
		TM helix 6	445..472	CDD:320167
		TM helix 7	477..502	CDD:320167
eva1c	XP_009303778.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594990
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930