Protein Alignment mthl14 and mthl8

DIOPT Version :9

• Sequence 1: NP_728509.1
• Gene: mthl14 / 318046
• FlyBaseID: FBgn0052476
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_001261182.1
• Gene: mthl8 / 38013
• FlyBaseID: FBgn0052475
• Length: 492
• Species: Drosophila melanogaster
• Alignment Length: 520
• Identity: 95/520 - (18%)
• Similarity: 189/520 - (36%)
• Gaps: 129/520 - (24%)

  Fly    34 GSNNSNIFHE---------DTFNSTSIDVLDAS-IHSTLVVPQTYSTEAATISGARFATSVPVQS 88
            |::.|..|||         ||.|.|....||.. :|:..|:|:.:      ::...|.....::.
  Fly    15 GTHCSWGFHEETHYPCAFIDTANITGSYGLDGPFVHNWTVIPRHF------VAVYDFVIENGIRI 73

  Fly    89 PVDNPLDPADCSQREKYRKQPVATPSSRLRKCCPHGENLNIYRENQSDSMCDNGLLSFEP--TII 151
            |....|....|..:          |..|:  ||..||   ||...:...:.....:|..|  :.:
  Fly    74 PASRHLRACVCKTK----------PCVRI--CCLRGE---IYDLEKRQCLVPVAGVSSLPSHSHM 123

  Fly   152 SAVLFDNCIEDLEVETTLDYDIGNPC-NSSLLYDDKDDVFFVLQDGSLLIIDKFGNESYTVKEHY 215
            ...|.:..:..::::......:..|| :...:....:.|.:.|.:...:     .:..:...:||
  Fly   124 EVELGNGSLRLVKLQPRFSIHVETPCEHMKAVTKGSEYVHWTLHENGTI-----SHRGHIFSKHY 183

  Fly   216 CLDIDKSGHLFAFTCV-----TQVEEQIAFA--KVVFV--------AVLMLISMPCLLLVSYLHM 265
            |           ||.:     |...:.:|.|  |:.||        |:.:||::..:.:|..:::
  Fly   184 C-----------FTPLLHGNSTWEWQPLACAPEKLYFVLGVREWTYAICLLIAILSMFIVLMVYL 237

  Fly   266 TLRLLRN-LHGLSLSLMSLCLASGYFVHSVVHIYG-----------IPNQGFIGYVIQFCILSYF 318
            ....:|| .:|:::...::|:..||.:.:.:.::.           :|:...:..|:.|.|||:.
  Fly   238 MCSEMRNSFYGVAIKAYAICMILGYALLAYLTLHNPANLSNAACRILPSLALMNLVLSFYILSFI 302

  Fly   319 FWYLCICFN----VLLNVWYKLPCCIQCSKSWATFNFACYAVFAFSGPATIVALTVQKGLPGMPS 379
            .:.|.:.|.    ..|..|......:..:..|:.|     ..|::.|...|..        |...
  Fly   303 AFKLYLSFYGVVFTKLMFWLIFTPIVLVAVGWSFF-----VGFSYYGSRLIFG--------GDTC 354

  Fly   380 YFLQGLTESIRDSQR-----YFIPPVSTILFLSFLLNIISFFGFQRISGYAKAEKNIQERKCLFD 439
            :|         |.:.     ||..||       |:...||.|.:.....|.:.:.:|:..|
  Fly   355 WF---------DPRNWSVMIYFYAPV-------FVACAISGFFYVLSQIYIRDQPDIETEK---- 399

  Fly   440 QQKYEDVKKDA-----KCVSLLGIIMVVSWLLEIITFY--SGSNSNYLI-LCDMVNGLQGVWVLL 496
              .:|.::|:.     |......::.||........:|  :.|:.||.: .|...:|...::.|:
  Fly   400 --SFESIEKNRFKSFWKYFGYTAVVWVVCICSFAFNYYWENRSHLNYAVSFCMAFHGFAALYALI 462

  Fly   497  496
              Fly   463  462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl14	NP_728509.1	7tmB3_Methuselah-like	239..512	CDD:320167	56/297 (19%)
		TM helix 1	241..266	CDD:320167	8/34 (24%)
		TM helix 2	275..297	CDD:320167	4/21 (19%)
		TM helix 3	306..331	CDD:320167	7/28 (25%)
		TM helix 4	349..369	CDD:320167	4/19 (21%)
		TM helix 5	389..418	CDD:320167	9/33 (27%)
		TM helix 6	445..472	CDD:320167	4/31 (13%)
		TM helix 7	477..502	CDD:320167	5/21 (24%)
mthl8	NP_001261182.1	Methuselah_N	30..202	CDD:284145	34/208 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462166
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840