DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mthl14 and Dh44-R1

DIOPT Version :9

Sequence 1:	NP_728509.1	Gene:	mthl14 / 318046	FlyBaseID:	FBgn0052476	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_610960.1	Gene:	Dh44-R1 / 36601	FlyBaseID:	FBgn0033932	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	295	Identity:	65/295 - (22%)
Similarity:	102/295 - (34%)	Gaps:	95/295 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 AVLFDNCIEDLEVETTLDYDIGNPCNSSLLYDDKDDVFFVLQDGSLLIIDKFGNESYTVKEHYCL 217
            |||  .|:::|:   .:.||           ..|:...|...:|:.        |.||
  Fly    72 AVL--QCMDELQ---GIHYD-----------SSKNATRFCHANGTW--------EKYT------- 105

  Fly   218 DIDKSGHLFAFTCVTQVEEQIAFAKVVFVA--VLMLISMPCLLLVSYLHMTLRLLRN-------- 272
            :.|...||.|...|.:.|..:....:::..  .|.|:|:...|:|......||.|||
  Fly   106 NYDACAHLPAPESVPEFEVIVELPTIIYYIGYTLSLVSLSLALIVFAYFKELRCLRNTIHANLFF 170

  Fly   273 ------LHGLSLSLMSLCLASGYFVHSVVHIYGIPNQGFIGYVIQFCILSYFFWYLCICFNVLLN 331
                  |..:.|..:.:.:.||  |.|.:.:..:         ..|..|:.|||       :|:.
  Fly   171 TYIMSALFWILLLSVQISIRSG--VGSCIALITL---------FHFFTLTNFFW-------MLVE 217

  Fly   332 VWYKLPCCIQCSKSWATFNFACYAVFAFSGPAT-IVALTVQKGLPGMPSYFLQGLTESIRDSQRY 395
            ..| |...:..:.|.....|..||...:.|||. :|...|.|           .||.:....::|
  Fly   218 GLY-LYMLVVKTFSGDNLRFNIYASIGWGGPALFVVTWAVAK-----------SLTVTYSTPEKY 270

  Fly   396 FI---------------PPVSTILF--LSFLLNII 413
            .|               .||..:|.  |:|||.|:
  Fly   271 EINCPWMQETHVDWIYQGPVCAVLIINLTFLLRIM 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mthl14	NP_728509.1	7tmB3_Methuselah-like	239..512	CDD:320167	46/209 (22%)
		TM helix 1	241..266	CDD:320167	5/26 (19%)
		TM helix 2	275..297	CDD:320167	5/21 (24%)
		TM helix 3	306..331	CDD:320167	6/24 (25%)
		TM helix 4	349..369	CDD:320167	7/20 (35%)
		TM helix 5	389..418	CDD:320167	10/42 (24%)
		TM helix 6	445..472	CDD:320167
		TM helix 7	477..502	CDD:320167
Dh44-R1	NP_610960.1	HRM	52..112	CDD:397086	14/70 (20%)
		7tmB1_DH_R	126..394	CDD:320391	46/210 (22%)
		TM helix 1	129..153	CDD:320391	5/23 (22%)
		TM helix 2	162..183	CDD:320391	2/20 (10%)
		TM helix 3	197..219	CDD:320391	6/37 (16%)
		TM helix 4	238..254	CDD:320391	6/15 (40%)
		TM helix 5	279..302	CDD:320391	5/22 (23%)
		TM helix 6	327..349	CDD:320391
		TM helix 7	356..381	CDD:320391
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462168
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840