Protein Alignment mthl14 and mth-1

DIOPT Version :10

• Sequence 1: NP_728509.1
• Gene: mthl14 / 318046
• FlyBaseID: FBgn0052476
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_001364699.1
• Gene: mth-1 / 185152
• WormBaseID: WBGene00017948
• Length: 1757
• Species: Caenorhabditis elegans
• Alignment Length: 589
• Identity: 108/589 - (18%)
• Similarity: 196/589 - (33%)
• Gaps: 197/589 - (33%)

  Fly    31 SSKGSNNSNIF-----HEDTFNSTSIDVLDASIHSTLVVPQTY-----STE---------AATIS 76
            |..|...|::|     |:..|:.                ||.|     |:|         |...:
 Worm  1270 SGSGEQVSHVFFTIYRHQKLFSG----------------PQKYRNYGSSSEEDDEEEDDPAMEEA 1318

  Fly    77 GARFATSVPVQSPVDNPLD-------PADCSQREKYRKQPVATP-----------------SSRL 117
            |||:.     :...:|..|       |:.||::...   |..||                 .|:|
 Worm  1319 GARYK-----RDTGNNNTDDIGQIPAPSKCSEQISI---PFGTPVLSASIIGGDQGAFISRMSKL 1375

  Fly   118 RKCCPHGENLNIYRENQSDSMCDNGLLSFEPTIISAVLFDNCIEDLEVETTLDYDIGN------P 176
            ....|....|.......|..:..|.::|:         |:...::.|::...|.::|:      .
 Worm  1376 VGAAPVMAKLQFNVGQMSRPLHGNTIVSW---------FNTGTQEWELQQKCDTEVGSDGIVTAS 1431

  Fly   177 CNSSLLYDDKDDVFFVLQDGSLLIIDKFGNESYTVKEHYCLDIDKSGHLFAFTC---VTQVEEQI 238
            |..             |.|.|:|:..:...|                    :.|   :|.:...:
 Worm  1432 CEH-------------LTDFSVLVYSQPNAE--------------------YVCSMPLTIIGYSV 1463

  Fly   239 AFAKVVFVAVLMLISMPCLLLVSYLHMTLRLLRNLHGLSLSLMSLCLASGYFVHSVVHIYGIPNQ 303
            ..|.:|.:.:|:||.:...:....:...|..:|.....:..:::|.....:|:..::.::.:...
 Worm  1464 NGASIVCLLLLILIGLMFYIRGELVRRVLIYIRGQAPTTGDVVNLAYYCVFFLFFILSLFFMDQS 1528

  Fly   304 G----FIG---YVIQFCILSYFFWYLCICFNVLLNVWYKLPCCIQCSK----------SWATFNF 351
            |    .:|   |.:....:|||.....|..::|:.:  ::.|.....|          ..|..:.
 Worm  1529 GGDDRSMGTSTYCVVIAAMSYFSLISAIMMSMLIGL--RMVCHFFSPKLRLFFGVMTSPPAALSI 1591

  Fly   352 ACYAVFAFSGPATIVALT-------------VQKGLPGMPSYFLQGLTESIRDSQRYFIPPVSTI 403
            .....|.|:   .|:||.             |:      |.|.:..:...:      .:|.::.:
 Worm  1592 GLIVPFTFT---LILALVDTSFFKRDDCFCWVR------PDYIVYAVVIPV------VLPIINGV 1641

  Fly   404 LFLSFLLNIISFFGFQRISGYAKAEKNIQERKCLFDQQKYEDVKKDAKCVSLLGIIMVVS----W 464
            :..||.  |...| ||...|.|..|.:            :.|.:..:|.:.|  |||.|:    |
 Worm  1642 ICSSFA--IYKMF-FQAKRGLASKETS------------HYDAEFWSKVMGL--IIMQVAMGLPW 1689

  Fly   465 LLEIITFYSGSNS--NYLILCDMVNGLQGVWVLLIFLVVRRR-RTIILRW------WYDRGSHEI 520
            .:|.|.......|  ||:.:  ::.|.||:.:.||||..|:| |....:|      |..:.|...
 Worm  1690 GIEFILIGVAGPSPWNYIFV--LLLGTQGIDLFLIFLYRRQRLRNESRKWSSREEKWETKRSRAA 1752

  Fly   521 EGTE 524
            |..|
 Worm  1753 EADE 1756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl14	NP_728509.1	7tmB3_Methuselah-like	239..512	CDD:410632	62/315 (20%)
		TM helix 1	241..266	CDD:410632	5/24 (21%)
		TM helix 2	275..297	CDD:410632	2/21 (10%)
		TM helix 3	306..331	CDD:410632	7/27 (26%)
		TM helix 4	349..369	CDD:410632	4/19 (21%)
		TM helix 5	389..418	CDD:410632	5/28 (18%)
		TM helix 6	445..472	CDD:410632	10/30 (33%)
		TM helix 7	477..502	CDD:410632	10/26 (38%)
mth-1	NP_001364699.1	GPS	1398..1447	CDD:470616	11/70 (16%)
		7tm_GPCRs	<1541..1733	CDD:475119	49/227 (22%)
		TM helix 3	1542..1564	CDD:410628	5/21 (24%)
		TM helix 4	1587..1603	CDD:410628	3/18 (17%)
		TM helix 5	1623..1645	CDD:410628	2/27 (7%)
		TM helix 6	1675..1697	CDD:410628	8/23 (35%)
		TM helix 7	1702..1727	CDD:410628	10/26 (38%)