DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tengl2 and NUC1

DIOPT Version :9

Sequence 1:	NP_722779.1	Gene:	Tengl2 / 318044	FlyBaseID:	FBgn0052463	Length:	318	Species:	Drosophila melanogaster
Sequence 2:	NP_012327.1	Gene:	NUC1 / 853222	SGDID:	S000003744	Length:	329	Species:	Saccharomyces cerevisiae

Alignment Length:	335	Identity:	112/335 - (33%)
Similarity:	166/335 - (49%)	Gaps:	58/335 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLGLGFVLGVTALCASFVGGMYFQHTDARKRLRELIQTDPYAYYLSPKIYEVFTFFESNNEDDHR 71
            |:|||...|:|.|..:       :|:..     ::|:| ||.....|          ::|...|.
Yeast    10 LVGLGAGTGLTYLLLN-------KHSPT-----QIIET-PYPPTQKP----------NSNIQSHS 51

  Fly    72 MR----QIMKFGFPG-LDDLRLYSDFVLSYDRRNRVAHWVCEHLQADSIHPNRGRRGRNPYQPDL 131
            ..    ...|:|||| :.||:...:|:..|:|:.:..:||.||:..:|:......|..:.::.|.
Yeast    52 FNVDPSGFFKYGFPGPIHDLQNREEFISCYNRQTQNPYWVLEHITPESLAARNADRKNSFFKEDE 116

  Fly   132 SVPSNFRSELSDYRRSGFDRGHLAAAGNHHLQQNHCEDTFFLTNIAPQVGQGFNRSAWNNLEQYV 196
            .:|..||.:|.||.|||:||||.|.|.:....|...:|||:|:|:.||||:||||..|.:||.:.
Yeast   117 VIPEKFRGKLRDYFRSGYDRGHQAPAADAKFSQQAMDDTFYLSNMCPQVGEGFNRDYWAHLEYFC 181

  Fly   197 RNLVHRFGSVFVCTGPLYKPNQRP-GGKWAVEYEMIGLN--MVAVPTHFFKVIMVESKLHLGKPY 258
            |.|..::.||.:.|||||.|.:.| ..|:.|.||:|| |  .:||||||||:|:.|:.  ...|.
Yeast   182 RGLTKKYKSVRIVTGPLYLPKKDPIDNKFRVNYEVIG-NPPSIAVPTHFFKLIVAEAP--TANPA 243

  Fly   259 ME-----GYVLPNAPIPDGLPLRSFLCDIREIEHYAGLKFFDGLRRSALFGSNYPSESR------ 312
            .|     .:||||.||.:...|..|...|..:|...||:....:.         ||:.:
Yeast   244 REDIAVAAFVLPNEPISNETKLTDFEVPIDALERSTGLELLQKVP---------PSKKKALCKEV 299

  Fly   313 ----VFREFS 318
                |.|:||
Yeast   300 NCQIVVRDFS 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tengl2	NP_722779.1	Endonuclease_NS	74..300	CDD:279553	91/234 (39%)
NUC1	NP_012327.1	NUC1	8..308	CDD:224777	110/332 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343681
Domainoid	1	1.000	206	1.000	Domainoid score	I527
eggNOG	1	0.900	-	-		E1_COG1864
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	207	1.000	Inparanoid score	I826
Isobase	1	0.950	-	0	Normalized mean entropy	S973
OMA	1	1.010	-	-		QHG52002
OrthoFinder	1	1.000	-	-		FOG0003231
OrthoInspector	1	1.000	-	-		otm46550
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3743
TreeFam	1	0.960	-	-
	13	12.810