DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tengl2 and ENDOD1

DIOPT Version :9

Sequence 1:	NP_722779.1	Gene:	Tengl2 / 318044	FlyBaseID:	FBgn0052463	Length:	318	Species:	Drosophila melanogaster
Sequence 2:	NP_055851.1	Gene:	ENDOD1 / 23052	HGNCID:	29129	Length:	500	Species:	Homo sapiens

Alignment Length:	218	Identity:	49/218 - (22%)
Similarity:	74/218 - (33%)	Gaps:	63/218 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 EDDHRMRQIMKFGFPGLDDLRLYSD--------------FVLSYDRRNRVAHWVCEHLQADSIHP 117
            |::....:..||.:.|.....|.:|              |...|..|:|:.  |....:|....|
Human    26 EEEAGFGECDKFFYAGTPPAGLAADSHVKICQRAEGAERFATLYSTRDRIP--VYSAFRAPRPAP 88

  Fly   118 NRGRRGRNPYQPDLSVP-SNFRSEL-------------------SDYRRSGFDRGHLAAAGNHHL 162
            . |...|...:|.:..| ||....:                   :||..|.:.||.|..   ..|
Human    89 G-GAEQRWLVEPQIDDPNSNLEEAINEAEAITSVNSLGSKQALNTDYLDSDYQRGQLYP---FSL 149

  Fly   163 QQNHCEDTFFLTNIAPQVGQGFNRSAWNNLEQYV-RNLVHRFGS---VFVCTGPL---YKPNQR- 219
            ..:....||.|||.||.. |.|....:.||...: |.|..:.||   :::.||.:   |:...:
Human   150 SSDVQVATFTLTNSAPMT-QSFQERWYVNLHSLMDRALTPQCGSGEDLYILTGTVPSDYRVKDKV 213

  Fly   220 --------------PGGKWAVEY 228
                          |||.||:.:
Human   214 AVPEFVWLAACCAVPGGGWAMGF 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tengl2	NP_722779.1	Endonuclease_NS	74..300	CDD:279553	48/211 (23%)
ENDOD1	NP_055851.1	NUC	65..281	CDD:294067	43/179 (24%)
ENDOD1	NP_055851.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	293..323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910