DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CAH3 and CA8

DIOPT Version :9

Sequence 1:	NP_001259349.1	Gene:	CAH3 / 31804	FlyBaseID:	FBgn0030056	Length:	250	Species:	Drosophila melanogaster
Sequence 2:	NP_001308766.1	Gene:	CA8 / 767	HGNCID:	1382	Length:	290	Species:	Homo sapiens

Alignment Length:	219	Identity:	70/219 - (31%)
Similarity:	110/219 - (50%)	Gaps:	21/219 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QSPIEISNRAIEHIDDVDPLEYHGHWEPVGV----ARVQNTGTSAMVTFSKRKQQPYIIGGALEQ 64
            ||||.:::|...:    ||........|..|    ..|.|.|.:..|..   |.:..:.||.|.|
Human    49 QSPINLNSREARY----DPSLLDVRLSPNYVVCRDCEVTNDGHTIQVIL---KSKSVLSGGPLPQ 106

  Fly    65 DMYVFE--QLHFHWSDCDESGCEHTLEGMKYSMEAHAVHYNSK-YKDFTEAKNKPDGLAVVAFFI 126
            . :.||  ::.|||...::.|.|||:....:.||.|.:|:||. :....||..||.|:|::|.|:
Human   107 G-HEFELYEVRFHWGRENQRGSEHTVNFKAFPMELHLIHWNSTLFGSIDEAVGKPHGIAIIALFV 170

  Fly   127 QACGEKDCPEFKKITEGIRIVQKIHTSASLDSDCLSWIGL--QELSKHYYTYKGSLTTAPYFESV 189
            |.  .|:....|.:||.::.:|  :...|....|.:...|  ..|.:.|:.|:||||..|..|.|
Human   171 QI--GKEHVGLKAVTEILQDIQ--YKGKSKTIPCFNPNTLLPDPLLRDYWVYEGSLTIPPCSEGV 231

  Fly   190 TWIIYRTPIYVSRGQVQVFRNLQS 213
            |||::|.|:.:|:.|::.||.|::
Human   232 TWILFRYPLTISQLQIEEFRRLRT 255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CAH3	NP_001259349.1	alpha_CA	4..233	CDD:238200	70/219 (32%)
CA8	NP_001308766.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
CA8	NP_001308766.1	alpha_CARP_VIII	35..289	CDD:239394	70/219 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3338
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1377476at2759
OrthoFinder	1	1.000	-	-		FOG0000047
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820