Protein Alignment CAH3 and CA3

DIOPT Version :10

• Sequence 1: NP_572497.1
• Gene: CAH3 / 31804
• FlyBaseID: FBgn0030056
• Length: 250
• Species: Drosophila melanogaster
• Sequence 2: NP_005172.1
• Gene: CA3 / 761
• HGNCID: 1374
• Length: 260
• Species: Homo sapiens
• Alignment Length: 237
• Identity: 77/237 - (32%)
• Similarity: 116/237 - (48%)
• Gaps: 26/237 - (10%)

  Fly     4 QSPIEISNRAIEHIDDVDP--LEYHGHWEPVGVAR-VQNTGTSAMVTFSKRKQQPYIIGGALEQD 65
            |||:|:..:.|.|...:.|  :.|.|     |.|: :.|.|.:..|.|.....:..:.||.| ..
Human    28 QSPVELHTKDIRHDPSLQPWSVSYDG-----GSAKTILNNGKTCRVVFDDTYDRSMLRGGPL-PG 86

  Fly    66 MYVFEQLHFHWSDCDESGCEHTLEGMKYSMEAHAVHYNSKYKDFTEAKNKPDGLAVVAFFIQACG 130
            .|...|.|.||...|:.|.|||::|:||:.|.|.||:|.||..|.||..:.||:||:..|::...
Human    87 PYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKYNTFKEALKQRDGIAVIGIFLKIGH 151

  Fly   131 EKDCPEFKKITEGIRIVQKIHTS------ASLDSDCLSWIGLQELSKHYYTYKGSLTTAPYFESV 189
            |..  ||:...:.:   .||.|.      ...|..||.     ...:.|:||:||.||.|..|.:
Human   152 ENG--EFQIFLDAL---DKIKTKGKEAPFTKFDPSCLF-----PACRDYWTYQGSFTTPPCEECI 206

  Fly   190 TWIIYRTPIYVSRGQVQVFRNLQSCPKDESK-KIVNNYREIQ 230
            .|::.:.|:.||..|:...|:|.|..::|.. .:|:|:|..|
Human   207 VWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPLVSNWRPPQ 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CAH3	NP_572497.1	alpha_CA	4..233	CDD:238200	77/237 (32%)
CA3	NP_005172.1	alpha_CA_I_II_III_XIII	1..259	CDD:239393	77/237 (32%)
		Involved in proton transfer. /evidence=ECO:0000269|PubMed:17427958	64..67		0/2 (0%)