DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42272 and PRPF39

DIOPT Version :9

Sequence 1:NP_729101.2 Gene:CG42272 / 318020 FlyBaseID:FBgn0259167 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_060392.3 Gene:PRPF39 / 55015 HGNCID:20314 Length:669 Species:Homo sapiens


Alignment Length:376 Identity:72/376 - (19%)
Similarity:110/376 - (29%) Gaps:136/376 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    83 SSNASRNDHMVQNNENPASFEQQTLQLQQQQQQATVQYAHISPLDK-------EVVERLIKQWAP 140
            |||.|..:......|:|..|..:.:.:.:.:|         ||.|.       |..|.......|
Human    12 SSNGSTGNSSEVVVEHPTDFSTEIMNVTEMEQ---------SPDDSPNVNASTEETEMASAVDLP 67

  Fly   141 IVWLAPEEKFMPLGVEEFLQYV--HPMDKDSSFRPGVPFREY-STKSHLVTNNEVQELLGNDKSF 202
            :.....|..|.| ..|:|.:.|  :|.|    |...|...:| ..::||:...:..:.......:
Human    68 VTLTETEANFPP-EYEKFWKTVENNPQD----FTGWVYLLQYVEQENHLMAARKAFDRFFIHYPY 127

  Fly   203 LYG----------RNPNEK-----------AVPI-----YGVVNLCPSTRAPAMPVVPTTPPTTT 241
            .||          |:.|.|           |:|:     ...:|....|..|..|          
Human   128 CYGYWKKYADLEKRHDNIKPSDEVYRRGLQAIPLSVDLWIHYINFLKETLDPGDP---------- 182

  Fly   242 RGVYIPVSIDPLEERNDTIR--------------RSSRLFPLFQRVKRESPTVPQYNQLNEYEEL 292
                         |.|:|||              ||.||:.::...:.|...:.:...:  |:.:
Human   183 -------------ETNNTIRGTFEHAVLAAGTDFRSDRLWEMYINWENEQGNLREVTAI--YDRI 232

  Fly   293 VMEATQ---------KPSVQQDSEPEPENGVPVNNFIANLADNVKFSGGTYP--DD--------- 337
            :...||         |..||.:...:...|.........||.....||...|  ||         
Human   233 LGIPTQLYSHHFQRFKEHVQNNLPRDLLTGEQFIQLRRELASVNGHSGDDGPPGDDLPSGIEDIT 297

  Fly   338 ------------------------NLEENSIGQAPEKEEGPGKGKLPGFHV 364
                                    |..|:.:.:....|||.   |.|.|||
Human   298 DPAKLITEIENMRHRIIEIHQEMFNYNEHEVSKRWTFEEGI---KRPYFHV 345

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42272NP_729101.2 DUF946 <367..>437 CDD:283705
PRPF39NP_060392.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23 4/10 (40%)
RNA14 50..>455 CDD:227438 61/329 (19%)
HAT 1 109..141 4/31 (13%)
HAT 2 143..175 5/31 (16%)
HAT 3 183..218 9/34 (26%)
HAT 4 220..253 5/34 (15%)
HAT 5 333..365 8/16 (50%)
HAT 367..399 CDD:214642
HAT 6 367..399
HAT 7 404..436
TPR repeat 455..483 CDD:276809
TPR_16 459..523 CDD:290168
TPR repeat 488..522 CDD:276809
TPR repeat 527..557 CDD:276809
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 599..634
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165143160
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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