Protein Alignment oc and OTX1

DIOPT Version :10

• Sequence 1: NP_001356934.1
• Gene: oc / 31802
• FlyBaseID: FBgn0004102
• Length: 664
• Species: Drosophila melanogaster
• Sequence 2: NP_055377.1
• Gene: OTX1 / 5013
• HGNCID: 8521
• Length: 354
• Species: Homo sapiens
• Alignment Length: 501
• Identity: 146/501 - (29%)
• Similarity: 194/501 - (38%)
• Gaps: 173/501 - (34%)

  Fly    47 PHGLEAVGF----------SQGMWGVNTRKQRRERTTFTRAQLDVLEALFGKTRYPDIFMREEVA 101
            |:|:..:|.          |.| :....||||||||||||:|||||||||.||||||||||||||
Human     9 PYGMNGLGLAGPAMDLLHPSVG-YPATPRKQRRERTTFTRSQLDVLEALFAKTRYPDIFMREEVA 72

  Fly   102 LKINLPESRVQVWFKNRRAKCRQQLQQQQQSNSLSSSKNASGGGSGNSCSSSSANSRSNSNNNGS 166
            ||||||||||||||||||||||    |||||.|.:.|:.|..       .||.....|.|.::|.
Human    73 LKINLPESRVQVWFKNRRAKCR----QQQQSGSGTKSRPAKK-------KSSPVRESSGSESSGQ 126

  Fly   167 SSNNNTQSSGGNNSNKSSQKQGNSQSSQQGGGSSGGNNSNNNSAAAAASAAAAVAAAQSIKTHHS 231
            .:.....||..::|:.||                  :::|..:||||......||||.|:.|..:
Human   127 FTPPAVSSSASSSSSASS------------------SSANPAAAAAAGLGGNPVAAASSLSTPAA 173

  Fly   232 SFLSAAAAAASGGTNQSANNNSNNNNQGNSTPNSSSSGGGGGSQAGGHLSAAAAAAALNVTAAHQ 296
            |.:.:.|:.:.|                 |.|.|              :|.....||.:.|:..|
Human   174 SSIWSPASISPG-----------------SAPAS--------------VSVPEPLAAPSNTSCMQ 207

  Fly   297 NSSPLLPTPATSVSPVSIVCKKEHLSGGYGSSVGGGGGGGGASSGGLNLGVGVGVGVGVGVGVSQ 361
            .|.......|.:..|:|           ||.  ||..|.|..:......|         ||..|.
Human   208 RSVAAGAATAAASYPMS-----------YGQ--GGSYGQGYPTPSSSYFG---------GVDCSS 250

  Fly   362 DLLRSPYDQLKDAGGDIGAGVHHHHSIYGSAAGSNPRLLQPGGNITPMDSSSSITTPSPPITPMS 426
            .|                |.:|.||         :|..|                      :||:
Human   251 YL----------------APMHSHH---------HPHQL----------------------SPMA 268

  Fly   427 PQSAAAAAHAAQSAQSAHHSAAHSAAYMSNHDSYNFWHNQYQQYPNNYAQAPSYYSQMEYFSNQN 491
            |.|.|...|        ||..||.....|:...::..|:.:|.|..:...          |::.:
Human   269 PSSMAGHHH--------HHPHAHHPLSQSSGHHHHHHHHHHQGYGGSGLA----------FNSAD 315

  Fly   492 QVNYNMGHSGYTASNFGLSPSPSFTGTVSAQAFSQNSLDYMSPQDK 537
            .::|.               .|......||...:.||.|.:..:|:
Human   316 CLDYK---------------EPGAAAASSAWKLNFNSPDCLDYKDQ 346

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
oc	NP_001356934.1	Homeodomain	68..123	CDD:459649	52/54 (96%)
OTX1	NP_055377.1	Homeodomain	39..95	CDD:459649	54/59 (92%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..146		22/83 (27%)
		TF_Otx	178..274	CDD:427350	35/195 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..305		17/86 (20%)