DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32409 and RRS1

DIOPT Version :9

Sequence 1:	NP_729108.2	Gene:	CG32409 / 318016	FlyBaseID:	FBgn0052409	Length:	349	Species:	Drosophila melanogaster
Sequence 2:	NP_055984.1	Gene:	RRS1 / 23212	HGNCID:	17083	Length:	365	Species:	Homo sapiens

Alignment Length:	352	Identity:	153/352 - (43%)
Similarity:	217/352 - (61%)	Gaps:	29/352 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 VKEVLAK-HQKELDKYKPITVEKHLECRLDVGSLLITDPNDFDDRELR---DNKEEYLTALTREN 64
            |:|:||| .|.|.:|.:.|||.|.||.:.|:|:||.:|.|  ....||   ...|..|.||.|:|
Human     6 VEELLAKAEQDEAEKLQRITVHKELELQFDLGNLLASDRN--PPTGLRCAGPTPEAELQALARDN 68

  Fly    65 TQLLVNAIWELPTERVDESIVAKLPEPTTVLPRLRKPPGPRPLTKWEKFAKEKGISKKKKDKKTY 129
            ||||:|.:|:||||||:|:|||:||||||.|||.:..|.|||||:|::||:.|||..|||....:
Human    69 TQLLINQLWQLPTERVEEAIVARLPEPTTRLPREKPLPRPRPLTRWQQFARLKGIRPKKKTNLVW 133

  Fly   130 DETMDKWVPTYGFKRAEAEKAKDWVLEVPQNADPNTDMFQKKIDLRNEKVAKNEIQRMKNIVRAK 194
            ||...:|...:|::||. :..|:|::|||.||||..|.|.|:|..:.|:|||||:.|::|:.||.
Human   134 DEVSGQWRRRWGYQRAR-DDTKEWLIEVPGNADPLEDQFAKRIQAKKERVAKNELNRLRNLARAH 197

  Fly   195 KIDMPRSGYLGPEA-ASSSQLLTAVTVAKSSTASVGKFQNKLPKEKEARGLGIKELIPGGKRKQS 258
            |:.:|.:..|.|.. .|..:|..|:.|||.||||||:||.:|||||..||       .|.|||..
Human   198 KMQLPSAAGLHPTGHQSKEELGRAMQVAKVSTASVGRFQERLPKEKVPRG-------SGKKRKFQ 255

  Fly   259 HI--TQTPEKEANLDLIKSVLNKKPKLDVSKAVSMEKRDNRLAREAEAENEPGKKGGKKPKGKGS 321
            .:  ....||:..|:|::.:.:|||:|||::|.:.:.|:     |.:.|....:|..:|.|.||.
Human   256 PLFGDFAAEKKNQLELLRVMNSKKPQLDVTRATNKQMRE-----EDQEEAAKRRKMSQKGKRKGG 315

  Fly   322 RKAVGKKSKGNRGQRAPGKKAQAGRKR 348
            |:..|.|.||       |..:|.|:::
Human   316 RQGPGGKRKG-------GPPSQGGKRK 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32409	NP_729108.2	RRS1	31..190	CDD:282755	80/161 (50%)
RRS1	NP_055984.1	RRS1	31..193	CDD:309876	81/164 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	233..253		12/26 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..365		21/68 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158298
Domainoid	1	1.000	161	1.000	Domainoid score	I4025
eggNOG	1	0.900	-	-		E1_COG5225
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41014
Inparanoid	1	1.050	257	1.000	Inparanoid score	I3157
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54339
OrthoDB	1	1.010	-	-		D1264304at2759
OrthoFinder	1	1.000	-	-		FOG0004650
OrthoInspector	1	1.000	-	-		oto88761
orthoMCL	1	0.900	-	-		OOG6_102760
Panther	1	1.100	-	-	LDO	PTHR17602
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1227
SonicParanoid	1	1.000	-	-		X3268
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800