DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Caf1-180 and RLF2

DIOPT Version :9

Sequence 1:	NP_572495.1	Gene:	Caf1-180 / 31801	FlyBaseID:	FBgn0030054	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	NP_015343.1	Gene:	RLF2 / 856129	SGDID:	S000006222	Length:	606	Species:	Saccharomyces cerevisiae

Alignment Length:	772	Identity:	189/772 - (24%)
Similarity:	314/772 - (40%)	Gaps:	248/772 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   315 TTAKDNK-----KDPLIAEDSKPKEVPKKETSKTGGKGKKEGAKPAEKSKKEEKEDSTTKS-KKE 373
            ||.|.||     ||.:..:|      ||::.|           .|..::.|:|    |.|| .||
Yeast    27 TTVKSNKFLTKEKDVITLDD------PKEDVS-----------GPMIETVKQE----TMKSINKE 70

  Fly   374 KADSPANNQKEQQIGVKKKTSEPEDASNSHKSVTAKKDSKKDEASTQVKSDNESPEAAEISMILS 438
            .||         ::....|.:..||....:|:...:........:.||.:.|       |..|.:
Yeast    71 CAD---------EMKTTPKKANAEDKLLCYKNSPIQSTKYDRNTNKQVPNGN-------IIAIET 119

  Fly   439 TSEANSSSSEHEMDADTDTAATDRPSAQKETRLNRKSLPEVTGAPKGLTPKQQRLMEQRKKAREE 503
            .|.::|..|:.|:.           |::||                              :|:.|
Yeast   120 KSRSSSPCSKRELS-----------SSKKE------------------------------EAKRE 143

  Fly   504 KEQKLAEERRLKQQDKEHREQQKKQERDEKEQQRKLERDQKEQQRKMEKEEKERKRQAEV-DSKN 567
            ||                   .|||:|.|::.:::|.| |:|:::|..|.|:||:|:||: ..|.
Yeast   144 KE-------------------LKKQQRAEEKHRKELLR-QEEKKKKELKVEEERQRRAELKKQKE 188

  Fly   568 EEKRKRNEAKEEVQRKKDEERRKKEQEREEAEQKKKRAAESFSKFFVPKQPKCGSGSNNTSYLEH 632
            ||||::.||:.|.:|:|:|||.|||:|....|:.|:||......||..      ...:||..:|
Yeast   189 EEKRRKEEARLEAKRRKEEERLKKEEEIRLKEEAKERAQSRIGNFFKK------LSDSNTPVVE- 246

  Fly   633 EQSSCDSSKASSQTLAFRPFQIKDDMLLAPIVRNSLGQEQRSQLDGLFRHRDEEADDEEEEEEQD 697
                     .|.....|.||..||.:.:     ::..:..:.:|:|..|..|:|..:.:::...|
Yeast   247 ---------KSDYEKFFLPFYAKDGVRV-----SNKWKLTKVELEGSKRKIDDELLNSKDKTSSD 297

  Fly   698 IVRRKPPNRANLYLSELSSGRRKPLKMQRDVKLQRRTKD--------EEDDDDVQVIDYLSPAGL 754
            .:           |:.|.| ||.|    |..|::|:..|        |:.||::|.:
Yeast   298 DL-----------LNWLQS-RRLP----RGHKIKRKAVDVLQQMPLKEKTDDELQSL-------- 338

  Fly   755 PIEVEQPKQLTRMKAKYLHFADNRRPPYYGTWRKKSSSISARRPLAQDKVLFDYEVDSDCEW-EE 818
                     |.::..||:.|.:|.|||:.||: ....::....|.:.....|:|:.|||.|| .|
Yeast   339 ---------LAQVPHKYIKFYENVRPPFIGTY-SMDFTLPPNDPFSTKGTGFNYDYDSDVEWVNE 393

  Fly   819 EEPGE--SLSASEDEKEKESEEE--SEEEYNEWYVPHGHLSDEELQNDGDGMEDGHTREAQKAK- 878
            ||.||  :|.:.|:|:|:|.:|:  ||.|::      |.|..|| .:|.||:      ...|.|
Yeast   394 EEEGEVDNLESGEEEEEEEDDEDVPSEGEFD------GFLDSEE-NSDLDGL------PCAKRKF 445

  Fly   879 ---------LQVLQQEFAQEMKKQTKKIKARLL----GPVWLDENGNKSELFPAIFAHTIDMYAC 930
                     |:...:..::|.|:..:::||.::    ||:...:....|.| |:..::: |:.|
Yeast   446 VGPLIPTICLKSNFENLSEENKRYLQQLKAEVIIETDGPIDPFKEPKTSSL-PSKRSNS-DLQA- 507

  Fly   931 WQVEPLSLEPPPEPERQDQTPEQPVPLQLDDRLMQQLVRLTHGNRNSKTFLINEYLEYLKTQATA 995
                        :...|.|:||:.....:.|.:  .|:||..|.::| ||.:.         ...
Yeast   508 ------------QTASQSQSPEKKQKAMITDPM--DLLRLFDGVQDS-TFSLG---------TVT 548

  Fly   996 EANQTTLP--SKAVLREKFDELASWKTVELSTPEAAAASANSAKKGRKPKKRLCWVV 1050
            |..|..||  :|..::....|.|                ..|:.||..|:|   ||:
Yeast   549 EIAQKNLPQYNKQTIKNTIKEYA----------------IRSSGKGDLPRK---WVI 586

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-180	NP_572495.1	GBP_C	<491..599	CDD:303769	38/108 (35%)
		coiled coil	573..584	CDD:293879	4/10 (40%)
		CAF1A	770..>814	CDD:289057	14/43 (33%)
		CAF1-p150_C2	947..>1127	CDD:292176	26/106 (25%)
RLF2	NP_015343.1	CAF1A	345..>387	CDD:403465	13/42 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15272
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010