DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Caf1-180 and FAS1

DIOPT Version :9

Sequence 1:	NP_572495.1	Gene:	Caf1-180 / 31801	FlyBaseID:	FBgn0030054	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	NP_176725.1	Gene:	FAS1 / 842858	AraportID:	AT1G65470	Length:	815	Species:	Arabidopsis thaliana

Alignment Length:	960	Identity:	197/960 - (20%)
Similarity:	335/960 - (34%)	Gaps:	346/960 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   356 EKSKKEEKEDSTTKSKKEKADSPANNQKEQQIGVKKKTSEPEDASNSHKSVTAK---------KD 411
            |.|...|.|:..|..:.:|    .|.:|.:...::..|||.:::..|..::..|         .|
plant     3 EVSTVNENENRKTMIEPKK----LNKRKREPTAIENLTSEEKESQISSLNLEMKGLFDYFREVMD 63

  Fly   412 SKK---------------------------------DEASTQVKSDNESPEAAEI-SMILSTSEA 442
            ..|                                 ||...::|...||.....: |.::|..:.
plant    64 KSKRTDLFSGFSECSSLNSMVALLMEEMSLPLSKLVDEIYLKLKEKTESVTMVAVKSAVVSVGQR 128

  Fly   443 NSSSSEHEMDADTDTAATDRPS-------------------AQKETRLNRKSLPEVTGAPKGLTP 488
            .|..   .::.|.|....|..|                   ..|..|..||.:.|...|...:..
plant   129 VSYG---VLNVDADVLEDDSESCLWCWETRDLKIMPSSVRGVLKLRRTCRKKIHERITAVSAMLA 190

  Fly   489 KQQR---------------------------------LMEQRKKAREEKEQKLAEERRLKQQDKE 520
            ..||                                 :|::......||:.|..|:..|||.:|.
plant   191 ALQREETEKLWRSDLSKAAEKLGKILSEVDIRSFMDNMMQKNSSEMAEKDSKREEKLLLKQLEKN 255

  Fly   521 HREQQKKQERDEKEQQRKLERDQKEQQRKMEKEEKERKRQAEVDSKNEEKRKRNEAKEEVQRKKD 585
            ..|.:|:::|        :||...:::.:.|||:| ..::|.||..|:|| :..|:::.:::::|
plant   256 RCEAEKEKKR--------MERQVLKEKLQQEKEQK-LLQKAIVDENNKEK-EETESRKRIKKQQD 310

  Fly   586 E-ERRKKEQEREEAEQKKKRAAE---SFSKFFVPKQPKCGSGSNNTSYLEHEQSSCDSSKASSQT 646
            | |:.:|.:|:|:||.||:...:   |..:.|:.|       |.::|.   .|....||:.::|.
plant   311 ESEKEQKRREKEQAELKKQLQVQKQASIMERFLKK-------SKDSSL---TQPKLPSSEVTAQE 365

  Fly   647 LAFRPFQIKDDMLLAPIVRNSLGQEQRSQLDGLFRHRDEEADDEEEEEEQDIVRRKPPNRANLYL 711
            |:....:            |.:|:..:: :|..|....|...|:...|.....|:         |
plant   366 LSCTKHE------------NEIGKVVQA-IDNAFSTTCEATVDDIRREHFASWRQ---------L 408

  Fly   712 SELSSGRRKPLKMQRD--------VKLQRR---TKDEEDDDDVQVIDYLSPAGLPIEVE------ 759
            ..|.|..:|...|:|.        :||...   |.|.|.:.:.|        |...|..
plant   409 GHLLSSSKKHWGMRRQPKSELFPKLKLSTNSGVTSDGEPNMEKQ--------GDGCEENNFDGRQ 465

  Fly   760 -QPKQLTRMKAK----YLHFADNRRPPYYGTWRKKSSSISARRPLAQDKVLFDYEVDSDCEWEEE 819
             :|....|.|::    .|.|..:.||.:||.|..:|..:..||||.:|..| |||||||.|||||
plant   466 CKPSSSNRKKSRRVKQLLQFDKSCRPGFYGIWPSQSQVVKPRRPLQKDPEL-DYEVDSDEEWEEE 529

  Fly   820 EPGESLSASEDEKEKESEE------ESEEEYNEWYVPHGHLSDEELQNDGDGMEDGHTREAQKAK 878
            |.|||||..|.::::..||      :.::..:::.||.|:||::|      |:
plant   530 EAGESLSDCEKDEDESLEEGCSKADDEDDSEDDFMVPDGYLSEDE------GV------------ 576

  Fly   879 LQVLQQEFAQEMKKQTKKIKARLLGPVWLDENGNKSELFPAIFAHTIDMYACWQVEPLSLEPPPE 943
                                                                 ||:.:.::|..:
plant   577 -----------------------------------------------------QVDRMDIDPSEQ 588

  Fly   944 -----PERQDQ-TPEQPVPLQLDDRLMQQLVRLTHGNRNSKTFLINEYLEYLKTQATAEANQTTL 1002
                 ..:||| :||....||....|..               |.:..|:  |||.....|.|
plant   589 DANTTSSKQDQESPEFCALLQQQKHLQN---------------LTDHALK--KTQPLIICNLT-- 634

  Fly  1003 PSKAVLREKFDELASWKTVELSTPEAAAASANSAKKGRKPKKRLCWVVASDMLEKFQLPDLQLQN 1067
                  .||...||: |.:|                |.:..:::|  :.:.|:.:|
plant   635 ------HEKVSLLAA-KDLE----------------GTQKVEQIC--LRALMVRQF--------- 665

  Fly  1068 QWNYTLTPKVSDGPDAAQQEQSPPADAVPAASPASNQTTNSAP----TTPISGQTQAGQGVKKRA 1128
            .|:..:...::|..|   ::|.....:...::|.||......|    .|.:|......||:
plant   666 PWSSLIEISINDIQD---EDQEASKFSCSQSTPPSNSKAKIIPDSDLLTVVSTIQSCSQGI---- 723

  Fly  1129 TLIMSVPRDQPIPSATKNKLISQFLQRQSDASKPKEKMQEKPPPIV-FDD 1177
                             |:::....|:..|.  ||.|:::|...|. |:|
plant   724 -----------------NRVVETLQQKFPDV--PKTKLRQKVREISDFED 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-180	NP_572495.1	GBP_C	<491..599	CDD:303769	33/141 (23%)
		coiled coil	573..584	CDD:293879	1/10 (10%)
		CAF1A	770..>814	CDD:289057	20/47 (43%)
		CAF1-p150_C2	947..>1127	CDD:292176	37/184 (20%)
FAS1	NP_176725.1	pneumo_PspA	175..>396	CDD:411490	56/253 (22%)
		tolA	<230..>336	CDD:236545	34/115 (30%)
		CAF1A	481..549	CDD:403465	34/68 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	67	1.000	Domainoid score	I3538
eggNOG	1	0.900	-	-		E1_KOG4364
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006059
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15272
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.000