DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Caf1-180 and Chaf1a

DIOPT Version :9

Sequence 1:	NP_572495.1	Gene:	Caf1-180 / 31801	FlyBaseID:	FBgn0030054	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	NP_038761.1	Gene:	Chaf1a / 27221	MGIID:	1351331	Length:	911	Species:	Mus musculus

Alignment Length:	1088	Identity:	292/1088 - (26%)
Similarity:	435/1088 - (39%)	Gaps:	323/1088 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 EEPLETSTADVAKGDSESSDDIEI--IAEELNPQKRQKVQTPREKSPENSSTSGKHTEEVMQKNG 260
            ||| |.:|...|..|.:......:  :.:...|.||..: .|:||..|::|
Mouse     3 EEP-EAATRTAAAVDCKDRPGFPVKRLIQARLPFKRLNL-VPKEKVEEDTS-------------- 51

  Fly   261 KDSKKQEESMKAVKESKKEEPKTAEQNKKND---------------------------QATIDLF 298
                                ||.|.::|..|                           |..||.|
Mouse    52 --------------------PKAAVESKVPDLQLSLGTFESQCHTGSHVGLSTKLVGGQGPIDSF 96

  Fly   299 MGKKME--------------TNKKDKPE-----------VKTTAKDNKKDPLIAEDSKPKEVPKK 338
            :...::              ::..|.||           |.||.:...|.    ::....|:...
Mouse    97 LRATIKPVPSVVIIDLTENCSDIPDSPEGHSELSPDTAGVVTTVEGAAKQ----QEHSAAELCLL 157

  Fly   339 ETSKTGGKGKKEGAKPAEKSKKEEKEDSTTKSKKEKADSPANN-QKEQQIGVKKKTSEPEDASNS 402
            ||             |::.:...|:|..:....|...|..|.: |...::....:|...::.|:.
Mouse   158 ET-------------PSDITCHMEEEPGSPGDPKRTGDCQAGSLQSCPELTPGSRTCPTKELSSW 209

  Fly   403 HKS----------VTAKKD---SKKDEAS-------TQVKSDNESPEAA-EISMILSTSEANSSS 446
            .|:          |...:|   :|...||       ..|.|::|..|:. |...|||.|..||||
Mouse   210 SKAGDLLFIEKVPVVVLEDILATKPSIASLPMMSLDRSVTSESEILESCPEDDSILSHSSTNSSS 274

  Fly   447 SEHEMDADTDTAATDRPSAQKETRLNRKSLPEVTGA------PKGLTPK-QQRLMEQRKKAREEK 504
                     .|::.:.||...|.|..|.| |.....      .||.|.| :.:|...|::.||||
Mouse   275 ---------PTSSPEGPSTPPEHRGGRSS-PSTPACRVAKNFVKGSTEKGRSKLHRDREQQREEK 329

  Fly   505 EQKLAEERRLKQQDKEHREQQKKQERDEKEQQRKLERDQKEQQRKME-KEEKERKRQAEVDSKNE 568
            |:...|.||.|::.::.:|::|  |..|||::.|.|:|:||:..|.. ||||.::||..:::|.|
Mouse   330 EKLREEIRRAKEEARKKKEEEK--ELKEKERREKREKDEKEKAEKQRLKEEKRKERQEALEAKLE 392

  Fly   569 EKRKRNEAKEEVQRKKDEERRKKEQEREEAEQKKKRAAESFSKFFVPKQPKCGSGSNNTSYLEHE 633
            ||||    |||.:|.::||:|.:|:|: ..:.:|......|.|...|:.||..:|
Mouse   393 EKRK----KEEEKRLREEEKRLREEEK-RIKAEKAEITRFFQKPKTPQAPKTLAG---------- 442

  Fly   634 QSSCDSSKASSQTLAFRPFQIKDDMLLAPIVRNSLGQEQRSQLDGLFRHRDEEADDEEEEEEQDI 698
              ||..         |.||:||:.|:|||..|.:|.|:...|||.|.             ::|.:
Mouse   443 --SCGK---------FAPFEIKEHMVLAPRCRAALDQDLCDQLDQLL-------------QQQSV 483

  Fly   699 VRRKPPNRANLYLSELSSGRRKPLK-------------MQRDVKLQRRTKDEEDDDDVQVIDYLS 750
                    |:.:||:|.|  |.||:             |.|||.:...:|          :|
Mouse   484 --------ASTFLSDLKS--RLPLRSGPTRVCGHDTDIMNRDVVIVESSK----------VD--- 525

  Fly   751 PAGLPIEVEQPKQLTRMKAKYLHFADNRRPPYYGTWRKKSSSISARRPLAQDKVLFDYEVDSDCE 815
                  .|.:.|:..||  |.|.|::|.||.|:|||.||::.|..|.|.||||.|.|||||||.|
Mouse   526 ------GVSERKKFGRM--KLLQFSENHRPAYWGTWNKKTAIIRPRNPWAQDKDLLDYEVDSDDE 582

  Fly   816 WEEEEPGESLSASE-DEKEKESEEESEEEYNEWYVPHGHLSDEELQNDGDGMEDGHTRE-AQKAK 878
            |||||||||||.|| ||.:...|:|.|::  .::||||:||::|          |.|.| |....
Mouse   583 WEEEEPGESLSHSEGDEDDDVGEDEDEDD--GFFVPHGYLSEDE----------GVTEECADPEN 635

  Fly   879 LQVLQQEFAQEMKKQTKKIKA-RLLGP-----VWLDENGN--KSELFPAIFAHTIDMY-ACWQVE 934
            .:|.|:..|:|..:...|.|. |:|.|     ||..|..|  .|:|      ..:..: ||.
Mouse   636 HKVHQKLKAKEWDELLAKGKRFRVLQPVHVGCVWASEAANCTSSDL------KLLQQFTACL--- 691

  Fly   935 PLSLEPPPEPERQDQTPEQPVPLQLDDRLMQQLVRLTHGNRNSKTFLINEYLEYLK--------- 990
             |.:..|.|||......|     :.|..::.||:.|.|||.|....:|:|:.|..:
Mouse   692 -LDVASPDEPEPGASRRE-----KRDQHILAQLLPLLHGNVNGSKVIIHEFQEQCRRGLLTLPSP 750

  Fly   991 ---TQATAEANQTTLPSKAVLREKFDELASWKTVELSTPEAAAASANSAKKGRKPKKRLCWVVAS 1052
               .|.....:...:||||.|:....|                   |||.: ::|..|:||.|..
Mouse   751 TPHLQMPNLEDAVAVPSKARLKRLISE-------------------NSAYE-KRPNFRMCWYVHP 795

  Fly  1053 DMLEKFQLPDLQLQNQWNYTLTPKVSDGPDAAQQEQSPPADAVP---AASPASNQ-TTNSAPTTP 1113
            ::|:.|....|.:..||.|..|...:...|:.......|..:.|   ...||:.. .|.......
Mouse   796 EVLKSFGQECLPVPCQWTYITTMPSAPREDSGSASTEGPGQSTPMLLKRKPAATMCITQFMKKRR 860

  Fly  1114 ISGQTQAGQGVKKRA-----------TLIMSVP------RDQPIPSAT 1144
            ..||..:|.....:|           .:|:.||      .:.|||:.|
Mouse   861 YDGQVGSGDMDGFQADTEEDEEDDTDCMIIDVPDVGSDVSEAPIPAPT 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-180	NP_572495.1	GBP_C	<491..599	CDD:303769	44/108 (41%)
		coiled coil	573..584	CDD:293879	4/10 (40%)
		CAF1A	770..>814	CDD:289057	26/43 (60%)
		CAF1-p150_C2	947..>1127	CDD:292176	43/195 (22%)
Chaf1a	NP_038761.1	CAF1-p150_N	1..210	CDD:292194	43/259 (17%)
		Binds PCNA. /evidence=ECO:0000250	1..31		7/28 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..200		6/33 (18%)
		Binds CBX1 and CBX3 chromo shadow domains	176..327		39/160 (24%)
		PxVxL motif	217..230		2/12 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..408		64/173 (37%)
		CAF-1_p150	<373..458	CDD:288454	36/110 (33%)
		CAF1A	537..>575	CDD:289057	20/37 (54%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..618		24/41 (59%)
		Necessary for homodimerization and competence for chromatin assembly. /evidence=ECO:0000250	621..657		12/45 (27%)
		Binds to p60. /evidence=ECO:0000250	639..911		72/305 (24%)
		CAF1-p150_C2	644..909	CDD:292176	71/300 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..843		3/23 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	866..886		2/19 (11%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	94	1.000	Domainoid score	I7503
eggNOG	1	0.900	-	-		E1_KOG4364
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006059
OrthoInspector	1	1.000	-	-		oto92471
orthoMCL	1	0.900	-	-		OOG6_106916
Panther	1	1.100	-	-	LDO	PTHR15272
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5940
SonicParanoid	1	1.000	-	-		X4979
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.800