Protein Alignment Caf1-180 and eis1

DIOPT Version :10

• Sequence 1: NP_572495.1
• Gene: Caf1-180 / 31801
• FlyBaseID: FBgn0030054
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_587987.1
• Gene: eis1 / 2538827
• PomBaseID: SPCC63.14
• Length: 1184
• Species: Schizosaccharomyces pombe
• Alignment Length: 1229
• Identity: 232/1229 - (18%)
• Similarity: 419/1229 - (34%)
• Gaps: 399/1229 - (32%)

  Fly     9 PLSGRKKDAAVPAKSAE-KTASGGKKFVQTRLPFKLLTPGGGAVPTSSSSSSSPATIGSG----- 67
            |.:|:...:|....|.| :.:|.......|:.||..  |.|....|||.:::|...:.||
pombe   127 PHAGKAAQSAHVMNSTESRPSSAHVSSSYTQKPFAF--PLGPVFATSSQAAASETALPSGYEPDE 189

  Fly    68 --------------------PVTVILDEDDPAPRK------------RKLSYDDESPSEGTGCST 100
                                |...: |:|.|.|.:            |..:|.:|. |:....||
pombe   190 ARFIGASQLAKLSASHAHQTPAQTV-DDDVPLPTRMAATELVGHIPLRAANYANEY-SQDVPAST 252

  Fly   101 GQ----------LRRS---TSKENLDLA------SSIATKKVKTTDSVVEDVIELDEDEADKEIE 146
            .:          :|.|   ..|.:||.|      |..|...|.....|:|     :|:|...|::
pombe   253 HRAASELVHGVPMRASGINDPKHDLDAATRHNINSVAAASYVAARSRVIE-----EEEEPPNEVK 312

  Fly   147 DQDQLVEAKSSKEVKLKPKKSEGKKGSPAPIQIKLPLVNKRSKRRKSLKKSEEPLETSTADVAKG 211
            ::   ::.::..:.:::.....|..|:                   :|:      |.:..|:...
pombe   313 ER---MDYEADAQRRIRKMNVFGSAGA-------------------ALR------ERTQQDLMAN 349

  Fly   212 DSESSDDIEIIAEELNPQKRQKVQTPREKSPENSSTSGKHTEEVMQKNGKDSKKQEESMKAVKES 276
            :.|.|.:....:..|. .......|...|.|.:|.|:...|.:|.:.|   :.|.:.|:......
pombe   350 EQEHSGEFAGFSRNLT-NTAAAPTTYEYKRPTSSYTAKDATSKVYRSN---TYKPKSSVNGSVYR 410

  Fly   277 KKEEPKTAEQNKKNDQATIDLFMGKKME---------TNKKDKPEVKTTAKDNKKDPLIAEDSKP 332
            .|....|...||..::.::..:..|.|.         ::|...|.|:.|    :.|.:..||::.
pombe   411 SKSVKSTTSHNKVPERNSVPAYNEKLMHSSAANAAILSHKNYSPPVQPT----RDDEVSQEDARV 471

  Fly   333 KEVPKKETSKTGGKGKK----EGAKPAEKSKKEEKEDSTTKSKKEKADSPANNQKEQQIGVKKKT 393
            ||:.         :|.|    ..:..|...:..||:|..|..:...........::.::.:.|..
pombe   472 KEIV---------RGMKLPLTSSSLSAAAYRPMEKQDPATVERHHIQAEATQRVRDMKLDLTKLE 527

  Fly   394 SEPEDASNSH--KSVTAKKDSKKDEAST---QVKSDNESPEAAEI-SMILSTSEANSSSSEHEMD 452
            |:..|...|:  ::|..|..:    |:|   .:.|...:|:|..: |.:::.||     .:.|:|
pombe   528 SKTNDEIRSYRPRNVVIKPYA----AATPPKNIPSTYRAPQAPSVLSPVVTASE-----GDFELD 583

  Fly   453 A------DTDTAATDRPSAQKE----------------TRLNRKSLPEVTGAPKGLTPKQQRLME 495
            .      .|.|.:|.:.|:|:.                .|.:|.||..:          .:|:|.
pombe   584 GITPERQQTMTRSTYQESSQRPFHEDPFRTHPGLLQAVARNHRNSLANI----------DERIMR 638

  Fly   496 QRKKAR-----------EEKEQKLAEERRLKQQDKEHR-----EQQKKQERDEKEQQRKLERDQK 544
            |.:.|.           |..|::|::..|::.|::.:.     .:....|..|:..:|.::....
pombe   639 QNQAATANTNTVSETDIEALERRLSKAYRMEAQEEAYAINIGGGRVISPEELEEIARRNVDPMVS 703

  Fly   545 EQQRKMEKEEKERKRQAEVDSKNEEKRKRNEAKEEVQRKKDEERRKKEQEREEAEQKKKRAAESF 609
            |...: ..:|:|||.||:     |.||.:..||||.:.||.||:.:|.:|:...:::.|.|.:
pombe   704 ELSER-AAQERERKEQAK-----EAKRLKKLAKEEKRLKKKEEKARKAEEKRLQKERAKYAKQ-- 760

  Fly   610 SKFFVPKQPKCGSGSNNTSYLEHEQSSCDSSKASSQTLAFRPFQIKDDMLLAPIVRNSLGQEQRS 674
                                :..|.:..|.:.|::..:| .|:
pombe   761 --------------------MSRESAHADQAIANTGPVA-PPY---------------------- 782

  Fly   675 QLDGLFRHRDEEADDEEEEEEQDIVRRKPPNRANLYLSELSSGRRKPLKMQRDVKLQRRTKDEED 739
                 |.|..|.:..||||||:...||:..:    :.|| |||..:..:.:     |..|....:
pombe   783 -----FEHETEPSHYEEEEEEEPEERREESS----HFSE-SSGNNEFEETE-----QEYTHGYGN 832

  Fly   740 DDDVQVIDYLSPAGLPIE-----VEQPKQLTR----------MKAKYLHFADNRRPPYYGTWRKK 789
            |..||..|.::..|....     |.:.:.|.|          ....|.|..:...|..|....|.
pombe   833 DVLVQRTDVVNNFGESSHAHDNAVNEKRDLGRNGFGDVDEQDATEVYRHSIERIVPGDYLHDEKT 897

  Fly   790 SSSISARRPL--AQDKVLFDYEVDSDCEWEEEEPGESLSASEDE-------KEKESEEESEEEYN 845
            ..:::...|.  :::.|:   ||.     :|:.|    .|||.|       :::.|.|.|.|..:
pombe   898 RDTLTRESPAFRSEEAVV---EVA-----DEDHP----HASEAERAHSYSNRKQASSESSPESQS 950

  Fly   846 EWYVPHGHLSDEELQNDGDGMEDGHTREAQKAKLQVLQQEFAQEMKKQTKKIKARLLGPVWLDEN 910
            ..|            ||.:|.||...|:.     ..:.::..||....|.|:
pombe   951 THY------------NDYEGTEDNIVRQT-----TTVDEDGHQEQTTSTTKV------------- 985

  Fly   911 GNKSELFPAIFAHTIDMYACWQVEPLS--LEPPPEPERQD---------QTPEQP---------- 954
                       ||.|         |:|  |..||. ||.|         .:|:.|
pombe   986 -----------AHPI---------PVSNGLSSPPR-ERLDDNAKEILSRSSPKSPVAWFKRKFKN 1029

  Fly   955 ------VPLQLDDRLMQQLVR-------------LTHGNRNSKTFLINEYLEYLKTQATAEA--- 997
                  |...|::...:||..             ::|...::|..:.|.......|.....:
pombe  1030 RKDKAAVKRMLEEDSSKQLSSGRDVVAPTSVNHDVSHVGESTKPAVNNSTKPVAVTSKNGHSRNG 1094

  Fly   998 ----------------NQTTLPSKAVLREKFDELASWKTVELSTPEAAAASANSAKKGR 1040
                            |.:.:|:...|::..:..|..||.::....:..::.|...|.|
pombe  1095 SHAAHSNNVIGTQPHVNVSAVPNTGNLKDALEGSAVSKTDDVDNVVSGHSNVNGVSKSR 1153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-180	NP_572495.1	PTZ00121	<131..603	CDD:173412	101/528 (19%)
		CAF1A	770..>813	CDD:463507	9/44 (20%)
		CAF1-p150_C2	947..>1127	CDD:434777	20/151 (13%)
eis1	NP_587987.1	Eisosome1	614..729	CDD:432763	26/130 (20%)