DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Caf1-180 and chaf-1

DIOPT Version :9

Sequence 1:	NP_572495.1	Gene:	Caf1-180 / 31801	FlyBaseID:	FBgn0030054	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	NP_492440.1	Gene:	chaf-1 / 172730	WormBaseID:	WBGene00011532	Length:	479	Species:	Caenorhabditis elegans

Alignment Length:	584	Identity:	163/584 - (27%)
Similarity:	260/584 - (44%)	Gaps:	173/584 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   365 DSTTK----SKKEKADSPANNQKEQQIGVKKKTSEPEDASNSHKSVTAKKDSKKDEASTQVKSDN 425
            |:||.    ...|.:..|  |||    |||:....|.:           ||:||    .::..|:
Worm     8 DNTTDDVLIETNENSCDP--NQK----GVKRVAQTPPE-----------KDAKK----VKLSRDS 51

  Fly   426 ESPEAAEISMILSTSEANSSSSEHEMDADTDTAATDRPSAQKETRLNRKSLPEVTGAPKGLTPKQ 490
            .:....|:|                     ||      |.||||.......|:....||  |||.
Worm    52 SNQSVIELS---------------------DT------SPQKETSQQSPKAPKTPKTPK--TPKV 87

  Fly   491 QR---------LMEQRKKAREEKEQKLAEERRLKQQDKEHREQQKKQERDEKEQ-QRKLERDQKE 545
            .|         .||:|:|.|.|:| ::.||:|| ::||...|::..:|:.|||: .:|||.|:|:
Worm    88 SREEREKQKREKMEEREKQRIERE-RILEEKRL-EKDKLAEEKRLDKEKKEKERLDKKLEEDKKK 150

  Fly   546 QQRKMEKEEKERKRQAEVDSKNEEKRKR---NEAKEEVQRKKDEERRKKEQEREEA-EQKKKRAA 606
            ::::.|.|||::|.:.|...|:||:.||   .|.|:|.:|::|||:::.:::.||| |::|:|.:
Worm   151 EEKRKEAEEKKKKDEEEKMKKDEERNKRKKEEEEKKEAKRREDEEKKEAKRKEEEAIEERKRRQS 215

  Fly   607 ESFSKFFVPKQPKCGSGSNNTSYLEHEQSSCDSSKASSQTLAFRPFQIKDDMLLAPIVRNSLGQE 671
            ..|:|||...:.|               ...:..|.||..  :.||:.||.|.||.|:
Worm   216 ALFAKFFSKVEKK---------------KVAEPQKESSNW--YLPFERKDGMSLAKII------- 256

  Fly   672 QRSQLDGLFRHRDEEADDEEEEEEQDIVRRKPPNRANLYLSELSSGRRKPLKMQRDVKLQRRTKD 736
                      .||...||                 |:::                       |:.
Worm   257 ----------SRDPLPDD-----------------ADIF-----------------------TQH 271

  Fly   737 EEDDDDVQVIDYLSPAGLPIEVEQPKQLTRMKAKYLHFADNRRPPYYGTWRKKSSSISARRPLAQ 801
            ||.:   .:..::..|...:.:|..| ...||||...|..||||.|||||||||..:|...|||:
Worm   272 EEIN---SIASFIESAAKIVPIESSK-ARNMKAKLFQFHGNRRPQYYGTWRKKSKIVSGSCPLAE 332

  Fly   802 DKVLFDYEVDSDCEWEEE-EPGESLSASEDEKEKESEEESEEEYNEWYVPHGHLSDEELQNDG-- 863
            : :..||.|.||.|||:| ..||..::.:|.::...:::..||.:.::||..:|||.|...|.
Worm   333 E-IGIDYNVVSDDEWEDEPSDGEECNSDDDAEKDNDDDDGGEEDDGFFVPPCYLSDGEGDEDSTS 396

  Fly   864 -------------------DGMEDGHTREA--QKAKLQVLQQEFAQEMKKQTKKIKARLLGPVW 906
                               |..:|.::.:|  :||:|....:::|:...|:...:|.|.:|||:
Worm   397 DNDIAGDKKKEKQPKRITIDSDDDENSTDAAERKARLAQRAEDWAKRTGKKELAMKPRAVGPVF 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Caf1-180	NP_572495.1	GBP_C	<491..599	CDD:303769	45/121 (37%)
		coiled coil	573..584	CDD:293879	5/13 (38%)
		CAF1A	770..>814	CDD:289057	23/43 (53%)
		CAF1-p150_C2	947..>1127	CDD:292176
chaf-1	NP_492440.1	CAF1A	301..>358	CDD:289057	30/57 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I6477
eggNOG	1	0.900	-	-		E1_KOG4364
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006059
OrthoInspector	1	1.000	-	-		oto17991
orthoMCL	1	0.900	-	-		OOG6_106916
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5940
SonicParanoid	1	1.000	-	-		X4979
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.700