DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32373 and nell2a

DIOPT Version :9

Sequence 1:	NP_001261534.1	Gene:	CG32373 / 318000	FlyBaseID:	FBgn0052373	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001073544.1	Gene:	nell2a / 790930	ZFINID:	ZDB-GENE-030131-7972	Length:	811	Species:	Danio rerio

Alignment Length:	495	Identity:	111/495 - (22%)
Similarity:	166/495 - (33%)	Gaps:	167/495 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 LVTYYSC--RVNYKLKRAKD-NALYCSNGIWLGLKPNCIKIGKGNTHSMKQKKMRCRIDNGGCAH 133
            |...:.|  |..:::..|:| .||.|:....:.|...|.::.:|  |....::..|. :|..|.:
Zfish   352 LCQLFQCRDRTMHRVPGAEDCPALSCAESDQITLTDRCCRVCRG--HDFCAEENICS-ENSDCVN 413

  Fly   134 ICNRSTHKCECYEGYTLNSTDLRSCNDIDECKESNGGCSQ--VCNNLPGEFICTCNSGFEIDESD 196
            :  .:...|.|..|:.....|...|.|||||.|....|.:  .|.|..|.|:|.|::||  ...|
Zfish   414 L--DAGASCGCKNGFRPLRLDSAYCEDIDECAEGRHYCRENTECVNTAGSFMCVCHTGF--IRID 474

  Fly   197 EKTCLDIDECADPELSWDCTAGCKNL--------------NGTY--------------------- 226
            :.:|.:.||||..:...|..|.|.|.              |||.
Zfish   475 DYSCTEHDECASGQHDCDENALCFNTVGGHSCSCKPGYSGNGTVCRALCDGRCLNGGSCASPNVC 539

  Fly   227 KCLPSLVGRVEPTDGDGFSPGEI-----------------VCKSGFK----LSDDGSECQDINEC 270
            .|:....|:...||.|..|.|.:                 .|:.|:.    .|.:|..|:||:||
Zfish   540 VCVQGFSGQNCETDIDECSEGLVQCAAHATCVNLPGWYHCECRDGYHDNEVFSANGESCRDIDEC 604

  Fly   271 DLADIDSDSWRMTYRYCEHK--CENTVGSYICHCPQGYHLLDD--QNSCI----------LDGSK 321
                      |.....|.:.  |.|..|.:.|.||.|::...|  .||.:          .|...
Zfish   605 ----------RTGRSTCANDTVCFNLDGGFDCRCPHGHNCSGDCIHNSRVRHNAQIWVLDTDHCS 659

  Fly   322 LPPSKDAPV-------SQEAPRKDI--CPLFKGPANGKASCDKYL------QNGFNYTRCNITCN 371
            :...::..|       ..|.|..|:  ||          .||..|      |||.      :|.:
Zfish   660 VCSCQEGQVKCRRMVCDCENPTVDVLCCP----------ECDPRLTSQCLHQNGL------LTYS 708

  Fly   372 AGYIMQGSQFAVCGHTGLWSSPEAKC----VESLALSCP------VLTPPRNGRFYPASCNNEPS 426
            :            |.|.:.|....:|    |:...||||      .|.|  .|...| .|.::|.
Zfish   709 S------------GDTWIDSCQRCQCLQGEVDCWPLSCPPVDCDFTLVP--EGECCP-RCVSDPC 758

  Fly   427 KSLAICELLCDRGYLPRMDTQLICAAPWG--------WIQ 458
            ::.|:           |.|....|....|        |::
Zfish   759 QAHAV-----------RSDISKTCIDEHGITRFSGSAWVK 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32373	NP_001261534.1	FXa_inhibition	124..158	CDD:291342	7/33 (21%)
		vWFA	<158..199	CDD:294047	17/42 (40%)
		FXa_inhibition	287..315	CDD:291342	10/31 (32%)
		CCP	340..398	CDD:153056	13/67 (19%)
nell2a	NP_001073544.1	LamG	40..211	CDD:304605
		VWC	271..327	CDD:302663
		EGF_CA	438..>470	CDD:284955	13/31 (42%)
		EGF_3	484..519	CDD:289699	9/34 (26%)
		EGF_CA	553..587	CDD:214542	6/33 (18%)
		EGF_CA	600..>631	CDD:284955	12/40 (30%)
		VWC	638..690	CDD:302663	9/61 (15%)
		VWC	707..753	CDD:302663	13/60 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910