DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32373 and sez6l2

DIOPT Version :9

Sequence 1:	NP_001261534.1	Gene:	CG32373 / 318000	FlyBaseID:	FBgn0052373	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_021327047.1	Gene:	sez6l2 / 557847	ZFINID:	ZDB-GENE-091204-189	Length:	894	Species:	Danio rerio

Alignment Length:	507	Identity:	93/507 - (18%)
Similarity:	148/507 - (29%)	Gaps:	194/507 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 CSNGI---WLGLKPNCIKIGKGNTHSMKQKKMRCRIDNGGCAHIC-----NRSTHKCECYEGYTL 150
            |.|..   |...:|.|:.:..|..           |.|.....|.     :.|.|.    .|..|
Zfish   292 CLNSTRPKWSTPEPQCVAVSCGGW-----------IRNATVGRILSPTLPSASNHS----SGSNL 341

  Fly   151 NSTDLRSCNDIDECKESNGGCSQVCNNLPGEFICTCNSGFE---IDESDEKTCL----------- 201
                  ||:.:.|.||.:                ..:..||   :||.::|..:
Zfish   342 ------SCHWLLEAKEGH----------------RLHLHFERVALDEDNDKLIVRSGNSTTAPLL 384

  Fly   202 ---DIDECADPELSWDCTAGCKNLNGTYKCLPSLVG-RVEPTDGD----------GFSPGEIV-- 250
               |:|:..:.....:.::....|......:|.|:. |.|..||:          .||..:|.
Zfish   385 FDSDLDDVPERGFVSEGSSLFVELTADSSSIPLLLALRYEAFDGEHCYEPYLPHGNFSSSDITFP 449

  Fly   251 --------CKSGFKLSDDGS---ECQDINECDLADIDSDSWRMTYRYCEHKC----ENTVGSYIC 300
                    |.:|| :.:.||   ||.|.|:        ..|..|...|...|    .:.||:.:.
Zfish   450 LGTVVSFSCAAGF-VMEQGSGVMECLDPND--------PHWNETEPVCRALCGGELTDPVGTVLS 505

  Fly   301 -HCPQGYHLLDDQNSCILDGSKLPPSKDAPVSQEAP-----RKDICPLFKG-------------- 345
             ..||.|....|   |:.   ::..|:|..:..:..     ..|:..||.|
Zfish   506 PDWPQSYSKGQD---CVW---QIHVSEDKRIELDVQILNIRHNDVLTLFDGHDLMSHVIGQYMGS 564

  Fly   346 ------PANGKASCDKY----------LQNGF--NYTRC--NITCNA------------------ 372
                  .:.|.....::          |..||  :|...  |.||:|
Zfish   565 RERFRVVSGGSEVTIQFQSDPDDSTFILSQGFLIHYREVEPNDTCSALPQIEFGWSSSSHPSLVR 629

  Fly   373 ----------GYIMQGSQFAVCGHTGLWSSPEAKCVESLALSCPVLTPPRNGRFYPASCNNEPSK 427
                      ||.:.||....|.....||:....||:       :...|..|.....:.:..|..
Zfish   630 GSVLTYQCQPGYDIVGSDIITCQWDLTWSNSPPTCVK-------IQQCPDPGEVVNGARSVHPES 687

  Fly   428 SLA---ICELLCDRGYLPRMDTQLIC-----AAPWGWIQRRWQDNVPQYVFQ 471
            ..|   :....|::||.....:|:.|     ..|      :|.|..|:.|.:
Zfish   688 GFAVGTVVRFTCNQGYQLEGPSQISCHGRDTGMP------KWSDRSPKCVLK 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32373	NP_001261534.1	FXa_inhibition	124..158	CDD:291342	7/38 (18%)
		vWFA	<158..199	CDD:294047	8/43 (19%)
		FXa_inhibition	287..315	CDD:291342	8/32 (25%)
		CCP	340..398	CDD:153056	19/119 (16%)
sez6l2	XP_021327047.1	CUB	139..247	CDD:238001
		CCP	252..307	CDD:214478	4/14 (29%)
		CUB	312..413	CDD:238001	21/137 (15%)
		CCP	431..489	CDD:153056	14/66 (21%)
		CUB	492..601	CDD:238001	18/114 (16%)
		CCP	<630..794	CDD:332582	23/117 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	72	1.000	Inparanoid score	I5289
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.050