DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32373 and cd248a

DIOPT Version :9

Sequence 1:	NP_001261534.1	Gene:	CG32373 / 318000	FlyBaseID:	FBgn0052373	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001092698.3	Gene:	cd248a / 323364	ZFINID:	ZDB-GENE-030131-2084	Length:	719	Species:	Danio rerio

Alignment Length:	426	Identity:	103/426 - (24%)
Similarity:	158/426 - (37%)	Gaps:	129/426 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 DNALYCSNG-----IWLGLKPNCIKIGKGNTHSMKQKKMRCRIDNGGCAHICNRS--THKCECYE 146
            |.::.|:..     .|....|.|.:..|.:.         |..|||||.|.|..:  .:.|:|.|
Zfish   222 DQSVLCTQKEDGTVFWNRDPPFCTETSKTSW---------CDQDNGGCHHFCIETGLHYYCDCNE 277

  Fly   147 GYTLNSTDLRSCNDIDECKESNGG-CSQVCNNLPGEFICTCNSGFEIDESDEKTCLDIDECADPE 210
            |:.| :.|..||...|.|   ||. |...|..:...:.|.|..|:.: ..||:.|:|:|||
Zfish   278 GFLL-AEDGVSCFPSDPC---NGAPCEFECLPVMDGYRCACPDGYML-APDERGCVDVDEC---- 333

  Fly   211 LSWDCTAGCKNLNGTYKCLPSLVGRVEPTDGDGFSPGEIVCKSGFKLSDDGSECQDINECDLADI 275
            |...|...|.|..||::|.                     |:.|::..:||: |:|::||    |
Zfish   334 LQSPCEHICVNSPGTFECR---------------------CRDGYQQDEDGA-CEDVDEC----I 372

  Fly   276 DSDSWRMTYRYCEHKCENTVGSYICHCPQGY-HLLDDQNSCILDGSKLPPSKDAPVSQ-EAPRKD 338
            ::.        |||.||||:||:||||..|: .|.:||:.|          .|....| |...:.
Zfish   373 NNP--------CEHACENTMGSHICHCHYGFAPLQEDQSHC----------HDVDECQIEGTCEQ 419

  Fly   339 ICPLFKGPANGKASCDKYLQNGFNYTRCNITC-----NAGYIMQGSQFAVCG--HT--------- 387
            :|..:    :|...|  |.:.|:|....:.:|     :...:...|...:.|  |:
Zfish   420 MCINY----DGGFEC--YCEEGYNLQPDHYSCRPLGEDTTTVFDPSSTPIWGPEHSLYPWHFSHG 478

  Fly   388 ----------------------GLWSSPEAKCVESLALSCPVLT---------PPRNGRFYPASC 421
                                  .|.:|.|.....:|..|.|.:|         .||:..|:|.:
Zfish   479 PDLKTPQDWQTKLPKVETVSTDSLLTSEEEPETTTLTESFPEVTNIDGYLHPEEPRHNAFFPPT- 542

  Fly   422 NNEPSKSLAICELLCDRGYLPRMDTQLICAAPWGWI 457
            ..:|:......|.......||...|   ....|.|:
Zfish   543 TPKPTPDYYEDESTTVPTELPSSTT---LGGAWNWL 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32373	NP_001261534.1	FXa_inhibition	124..158	CDD:291342	14/35 (40%)
		vWFA	<158..199	CDD:294047	12/41 (29%)
		FXa_inhibition	287..315	CDD:291342	17/28 (61%)
		CCP	340..398	CDD:153056	13/95 (14%)
cd248a	NP_001092698.3	CLECT_thrombomodulin_like	32..176	CDD:153070
		FXa_inhibition	253..288	CDD:291342	14/35 (40%)
		cEGF	309..332	CDD:289433	7/23 (30%)
		vWFA	<327..363	CDD:294047	14/60 (23%)
		vWFA	<365..402	CDD:294047	20/48 (42%)
		FXa_inhibition	417..445	CDD:291342	6/33 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000