DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32373 and Fbln1

DIOPT Version :9

Sequence 1:	NP_001261534.1	Gene:	CG32373 / 318000	FlyBaseID:	FBgn0052373	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001121019.1	Gene:	Fbln1 / 315191	RGDID:	1308667	Length:	705	Species:	Rattus norvegicus

Alignment Length:	315	Identity:	86/315 - (27%)
Similarity:	132/315 - (41%)	Gaps:	85/315 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 YSCRVNYKLKRAKDNALYCSNGIWLGLKPNCIKIGKGNTHSMKQKKMRCRIDNGGC---AHICNR 137
            |:|:.|.                     |||   |:|  :.:.::..|| :|...|   |..|.:
  Rat   334 YTCQKNV---------------------PNC---GRG--YHLNEEGTRC-VDVDECSPPAEPCGK 371

  Fly   138 STH--------KCECYEGYTLNSTDLRSCNDIDECKESNGG-CSQVCNNLPGEFICTCNSGFEID 193
            ..|        :|||..||..:... |:|.||:||:...|. |...|.|.||.:.|:|::||.:
  Rat   372 GHHCLNSPGSFRCECKAGYYFDGIS-RTCVDINECQRYPGRLCGHKCENTPGSYHCSCSAGFRL- 434

  Fly   194 ESDEKTCLDIDECADPELSWDCTAGCKNLNGTYKCLPSLVGRVEPTDGDGFSPGEIVCKSGFKLS 258
            ..|.::|.|::||    |:..|:..|.|:.|:|:|                     .|:.|::||
  Rat   435 SVDGRSCEDVNEC----LNSPCSQECANVYGSYQC---------------------YCRRGYQLS 474

  Fly   259 D-DGSECQDINECDLADIDSDSWRMTYRYCEHKCENTVGSYICHCP-QGYHL------LDDQNSC 315
            | ||..|:||:||.|.        .....|.::|.|..||:.|.|| .||.|      ..|.:.|
  Rat   475 DVDGVTCEDIDECALP--------TGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDEC 531

  Fly   316 ILDGSKLPPSKDAPVSQEAPRKDICPLFKGPANGKASCDKYLQNGFNYTRCNITC 370
            :........::.....|.:.|   |..|:.|.|.:.|.|.:.|...:..||..:|
  Rat   532 VTGIHNCSINETCFNIQGSFR---CLSFECPENYRRSADTFRQEKTDTVRCIKSC 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32373	NP_001261534.1	FXa_inhibition	124..158	CDD:291342	12/44 (27%)
		vWFA	<158..199	CDD:294047	16/41 (39%)
		FXa_inhibition	287..315	CDD:291342	12/34 (35%)
		CCP	340..398	CDD:153056	10/31 (32%)
Fbln1	NP_001121019.1	ANATO	30..85	CDD:237984
		ANATO	107..162	CDD:237984
		cEGF	201..221	CDD:289433
		EGF_CA	218..261	CDD:284955
		EGF_CA	264..>300	CDD:284955
		EGF_CA	310..356	CDD:284955	8/47 (17%)
		EGF_CA	358..391	CDD:214542	9/32 (28%)
		cEGF	381..404	CDD:289433	9/23 (39%)
		cEGF	423..446	CDD:289433	7/23 (30%)
		cEGF	462..486	CDD:289433	12/44 (27%)
		vWFA	<481..524	CDD:294047	17/50 (34%)
		cEGF	506..530	CDD:289433	8/23 (35%)
		EGF_CA	527..567	CDD:284955	9/42 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000