DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32373 and GAS6

DIOPT Version :9

Sequence 1:	NP_001261534.1	Gene:	CG32373 / 318000	FlyBaseID:	FBgn0052373	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_000811.1	Gene:	GAS6 / 2621	HGNCID:	4168	Length:	678	Species:	Homo sapiens

Alignment Length:	177	Identity:	67/177 - (37%)
Similarity:	86/177 - (48%)	Gaps:	44/177 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   142 CECYEGYTLNSTDLRSCN-DIDECKESNGGCSQVCNNLPGEFICTCNSGFEIDESDEKTCLDIDE 205
            |.|..|:     ..|.|: |::||.:.||||.|:|:|.||.|.|:|:||||: .||.:||.||||
Human   142 CLCKAGW-----GGRLCDKDVNECSQENGGCLQICHNKPGSFHCSCHSGFEL-SSDGRTCQDIDE 200

  Fly   206 CADPELSWDCTAGCKNLNGTYKCLPSLVGRVEPTDGDGFSPGEIVCKSGFKLSDDGSECQDINEC 270
            |||.|...:  |.||||.|:|.||                     |..||..|.....|:|::||
Human   201 CADSEACGE--ARCKNLPGSYSCL---------------------CDEGFAYSSQEKACRDVDEC 242

  Fly   271 DLADIDSDSWRMTYRYCEHKCENTVGSYICHCP--QGYHLLDDQNSC 315
                        ....||..|.|:.|||.|||.  .|..|..|.::|
Human   243 ------------LQGRCEQVCVNSPGSYTCHCDGRGGLKLSQDMDTC 277

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32373	NP_001261534.1	FXa_inhibition	124..158	CDD:291342	4/15 (27%)
		vWFA	<158..199	CDD:294047	22/41 (54%)
		FXa_inhibition	287..315	CDD:291342	13/29 (45%)
		CCP	340..398	CDD:153056
GAS6	NP_000811.1	Gla	53..92	CDD:306960
		EGF_CA	118..153	CDD:238011	4/15 (27%)
		FXa_inhibition	160..195	CDD:317114	19/35 (54%)
		EGF_CA	197..>227	CDD:214542	18/52 (35%)
		vWFA	<232..273	CDD:320736	16/52 (31%)
		LamG	298..450	CDD:238058
		Laminin_G_2	513..651	CDD:308045
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7421
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950