DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32373 and Egf

DIOPT Version :9

Sequence 1:	NP_001261534.1	Gene:	CG32373 / 318000	FlyBaseID:	FBgn0052373	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_036974.2	Gene:	Egf / 25313	RGDID:	2542	Length:	1132	Species:	Rattus norvegicus

Alignment Length:	301	Identity:	72/301 - (23%)
Similarity:	112/301 - (37%)	Gaps:	87/301 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 RNGEHVFLVTYYSC-----RVNYKLKRAK----------DNALYCS---NGIWLGLK---PNCIK 108
            |.|.|.::   :||     .:::...:|:          |..||.:   ..||:..|   .|.::
  Rat   222 REGSHGYI---HSCDYDGGSIHHIRHQARHDLLTMAIFGDKILYSALKEKAIWIADKHTGKNVVR 283

  Fly   109 I---------------------GKGNTHSMKQKKMRCRIDNGGCAHICNR---STHKCECYEGYT 149
            :                     |..| .:......||:...|.|.:..:.   ::..|.|.||||
  Rat   284 VNLDPASVPPRELRVVHLHAQPGTEN-RAQASDSERCKQRRGQCLYSLSERDPNSDSCACAEGYT 347

  Fly   150 LNSTDLRSCNDIDECKESNGGCSQVCNNLPGEFICTCNSGFEIDESDEKTCLDIDECADPELSWD 214
            | |.|.:.|.|::||...|.||:..|.|:||.:.|||.:||.: ..|.|.|.::..|  |....:
  Rat   348 L-SRDRKYCEDVNECALQNHGCTLGCENIPGSYYCTCPTGFVL-LPDGKRCHELVAC--PGNRSE 408

  Fly   215 CTAGCKNLNGTYKCLPSLVGRVEPTDGDGFSPGEIVCKSGFKLSDDGSECQDINECDLADIDSDS 279
            |:..|                :..:||.     ..:|.:|..|..||..|...:..|...
  Rat   409 CSHDC----------------ILTSDGP-----LCICPAGSVLGKDGKTCTGCSSPDNGG----- 447

  Fly   280 WRMTYRYCEHKC-ENTVGSYICHCPQGYHLLDDQNSCILDG 319
                   |...| ..::.|:.|.|..||.|..|:.||...|
  Rat   448 -------CSQICLPLSLASWECDCFPGYDLQLDRKSCAASG 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32373	NP_001261534.1	FXa_inhibition	124..158	CDD:291342	12/36 (33%)
		vWFA	<158..199	CDD:294047	17/40 (43%)
		FXa_inhibition	287..315	CDD:291342	9/28 (32%)
		CCP	340..398	CDD:153056
Egf	NP_036974.2	LDL-receptor class B 1	87..128
		LDL-receptor class B 2	129..170
		LY	152..193	CDD:214531
		LDL-receptor class B 3	171..212
		LDL-receptor class B 4	213..259		6/39 (15%)
		cEGF	339..360	CDD:403760	11/21 (52%)
		FXa_inhibition	361..396	CDD:405372	15/35 (43%)
		FXa_inhibition	402..437	CDD:405372	11/57 (19%)
		FXa_inhibition	444..477	CDD:405372	10/44 (23%)
		LDL-receptor class B 5	484..524
		LY	505..547	CDD:214531
		LDL-receptor class B 6	525..567
		LY	548..590	CDD:214531
		LDL-receptor class B 7	568..610
		LY	591..634	CDD:214531
		LDL-receptor class B 8	611..654
		LY	634..677	CDD:214531
		LDL-receptor class B 9	655..697
		LY	678..719	CDD:214531
		FXa_inhibition	746..781	CDD:405372
		EGF_CA	839..871	CDD:419698
		EGF_CA	873..913	CDD:214542
		EGF_3	919..>943	CDD:403986
		PHA03099	<974..>1016	CDD:165381
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1068..1096
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000