DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32373 and CLEC14A

DIOPT Version :9

Sequence 1:	NP_001261534.1	Gene:	CG32373 / 318000	FlyBaseID:	FBgn0052373	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_778230.1	Gene:	CLEC14A / 161198	HGNCID:	19832	Length:	490	Species:	Homo sapiens

Alignment Length:	283	Identity:	55/283 - (19%)
Similarity:	89/283 - (31%)	Gaps:	127/283 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 SMKQKKMRCRIDNGGCAHICNRSTHKCECYEGYTLNSTDLRSCNDIDECKESNGGCSQVCNNLPG 180
            ::::::..|.::|              |...|::..|:|                        ||
Human    95 ALERRRSHCTLEN--------------EPLRGFSWLSSD------------------------PG 121

  Fly   181 EFICTCNSGFEIDESDEKTCLDIDECADPELSWDCTA-GCKNLNGTYKCLPSLVGRVEPTD---- 240
                    |.|.|     |...::|   |:.|  ||| .|..|..|        |.|||..
Human   122 --------GLESD-----TLQWVEE---PQRS--CTARRCAVLQAT--------GGVEPAGWKEM 160

  Fly   241 -----GDGF---SPGEIVC-------------KSGFKL-------SDDGSE----CQ---DINEC 270
                 .:|:   ...|::|             ::.|:|       |..|:|    |:   .|:..
Human   161 RCHLRANGYLCKYQFEVLCPAPRPGAASNLSYRAPFQLHSAALDFSPPGTEVSALCRGQLPISVT 225

  Fly   271 DLADIDSDSWRMTY---------RY-----CEH--KCENTVGSYICHCPQGYHLLDDQNSCILDG 319
            .:||.....|....         ||     |..  .|.:.:|.:.|.|..|:.|..|..||:..|
Human   226 CIADEIGARWDKLSGDVLCPCPGRYLRAGKCAELPNCLDDLGGFACECATGFELGKDGRSCVTSG 290

  Fly   320 SKLP-------PSKDAPVSQEAP 335
            ...|       |::..|.:..:|
Human   291 EGQPTLGGTGVPTRRPPATATSP 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32373	NP_001261534.1	FXa_inhibition	124..158	CDD:291342	6/33 (18%)
		vWFA	<158..199	CDD:294047	5/40 (13%)
		FXa_inhibition	287..315	CDD:291342	8/29 (28%)
		CCP	340..398	CDD:153056
CLEC14A	NP_778230.1	CLECT_thrombomodulin_like	32..175	CDD:153070	26/143 (18%)
		FXa_inhibition	254..286	CDD:291342	8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..349		6/28 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	428..461
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000