DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32373 and Fbn2

DIOPT Version :9

Sequence 1:	NP_001261534.1	Gene:	CG32373 / 318000	FlyBaseID:	FBgn0052373	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_034311.2	Gene:	Fbn2 / 14119	MGIID:	95490	Length:	2907	Species:	Mus musculus

Alignment Length:	399	Identity:	115/399 - (28%)
Similarity:	159/399 - (39%)	Gaps:	117/399 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 NALYCSNGIWLG--------------LKP---NCIKIGKGNTHSMKQKKMRCRIDNGGCAHICNR 137
            |.|.|..|..:.              |.|   :|:.|   |..|:...  .||  ||.|.::.
Mouse  1158 NPLLCRGGTCVNTEGSFQCDCPLGHELSPSREDCVDI---NECSLSDN--LCR--NGKCVNMI-- 1213

  Fly   138 STHKCECYEGYTLNSTDLRSCNDIDECKESNGGCSQVCNNLPGEFICTCNSGFEIDESDEKTCLD 202
            .|::|.|..||.. :.|.:.|.|||||...||||...|.|..|.:.|:|:.|:.: ..|.::|.|
Mouse  1214 GTYQCSCNPGYQA-TPDRQGCTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYAL-MPDGRSCAD 1276

  Fly   203 IDECA-DPELSWDCTAG-CKNLNGTYKCLPSLVGRVEPTDGDGFSPGEIVCKSGFKLSDDGSECQ 265
            ||||. :|::   |..| |.|:.|.|:||                     |..||..|.|...|.
Mouse  1277 IDECENNPDI---CDGGQCTNIPGEYRCL---------------------CYDGFMASMDMKTCI 1317

  Fly   266 DINECDLADIDSDSWRMTYRYCEH-KCENTVGSYICHCPQGYHLLDDQNSCI-LDGSKLPPSKDA 328
            |:|||||          ....|.. :||||.||:||||..||.:......|. :|..::....
Mouse  1318 DVNECDL----------NPNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEIGAHN-- 1370

  Fly   329 PVSQEAPRKDICPLFKG----PANGKASC-DKYLQNGF---------NYT-RCNITCNAGYI-MQ 377
                       |.:...    |.:.|.|| :.::.||.         |.| :|:|  ||..: ..
Mouse  1371 -----------CDMHASCLNVPGSFKCSCREGWVGNGIKCIDLDECANGTHQCSI--NAQCVNTP 1422

  Fly   378 GSQFAVC--GHT--GLWSSPEAKCVESLALSCPVLTPPRNGRFYPASCNNEPSKSLAICELLCDR 438
            ||....|  |.|  |...|...:|.|:..| |      .||:     |.|.|....  ||  |:.
Mouse  1423 GSYRCACSEGFTGDGFTCSDVDECAENTNL-C------ENGQ-----CLNVPGAYR--CE--CEM 1471

  Fly   439 GYLPRMDTQ 447
            |:.|..|::
Mouse  1472 GFTPASDSR 1480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32373	NP_001261534.1	FXa_inhibition	124..158	CDD:291342	11/33 (33%)
		vWFA	<158..199	CDD:294047	17/40 (43%)
		FXa_inhibition	287..315	CDD:291342	13/28 (46%)
		CCP	340..398	CDD:153056	20/77 (26%)
Fbn2	NP_034311.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..58
		Interaction with MFAP4. /evidence=ECO:0000250\|UniProtKB:P35556	149..359
		TB	225..258	CDD:279073
		EGF_CA	276..>306	CDD:214542
		TB	375..412	CDD:279073
		EGF_CA	528..558	CDD:214542
		EGF_CA	568..609	CDD:214542
		EGF_CA	610..642	CDD:238011
		cEGF	631..654	CDD:289433
		EGF_CA	651..691	CDD:214542
		TB	708..744	CDD:279073
		cEGF	783..806	CDD:289433
		EGF_CA	803..838	CDD:238011
		TB	900..>928	CDD:279073
		TB	1005..1040	CDD:279073
		EGF_CA	1108..1142	CDD:214542
		EGF_CA	1151..1183	CDD:214542	4/24 (17%)
		EGF_CA	1193..1225	CDD:214542	12/40 (30%)
		cEGF	1216..1238	CDD:289433	8/22 (36%)
		FXa_inhibition	1239..1274	CDD:291342	12/35 (34%)
		Plasmod_Pvs28	1286..1439	CDD:283826	54/201 (27%)
		EGF_3	1364..1399	CDD:289699	7/47 (15%)
		EGF_3	1405..1440	CDD:289699	12/36 (33%)
		EGF_CA	1484..1519	CDD:214542
		EGF_CA	1525..1556	CDD:214542
		TB	1586..1621	CDD:279073
		EGF_CA	1643..1675	CDD:214542
		cEGF	1665..1688	CDD:289433
		Interaction with MFAP4. /evidence=ECO:0000250\|UniProtKB:P35556	1728..2164
		TB	1742..1779	CDD:279073
		EGF_CA	1801..1833	CDD:214542
		vWFA	<1840..1881	CDD:294047
		vWFA	<1880..1922	CDD:294047
		EGF_CA	1927..1961	CDD:214542
		EGF_CA	1966..2008	CDD:214542
		EGF_CA	2049..2089	CDD:214542
		TB	2106..2143	CDD:279073
		EGF_CA	2164..2205	CDD:214542
		EGF_CA	2206..2245	CDD:214542
		vWFA	<2244..2283	CDD:294047
		TB	2390..2425	CDD:279073
		vWFA	<2482..2522	CDD:294047
		vWFA	<2520..2556	CDD:294047
		EGF_CA	2607..>2636	CDD:214542
		Cadherin_repeat	<2821..>2868	CDD:206637
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA2W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900