DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32373 and Fbn1

DIOPT Version :9

Sequence 1:	NP_001261534.1	Gene:	CG32373 / 318000	FlyBaseID:	FBgn0052373	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_032019.2	Gene:	Fbn1 / 14118	MGIID:	95489	Length:	2873	Species:	Mus musculus

Alignment Length:	464	Identity:	125/464 - (26%)
Similarity:	173/464 - (37%)	Gaps:	145/464 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 IKNAKASVKLRRNGEHVFLVTYYSCRVN--YK-----LKRAKD------NALYCSNGIWLG---- 101
            |...:.|..|...|:.|.....:.|:.:  |:     :|...|      :.|.|..||...
Mouse  1073 IDECRISPDLCGRGQCVNTPGDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGICHNTEGS 1137

  Fly   102 ----------LKPN---CIKIGKGNTHSMKQKKMRCRID-----NGGCAHICNRSTHKCECYEGY 148
                      |.||   ||.|.:            |.:.     :|.|.::..:  ::|.|..||
Mouse  1138 YRCECPPGHQLSPNISACIDINE------------CELSANLCPHGRCVNLIGK--YQCACNPGY 1188

  Fly   149 TLNSTDLRSCNDIDECKESNGGCSQVCNNLPGEFICTCNSGFEIDESDEKTCLDIDECAD-PELS 212
            . .:.|...|.|||||...||||...|.|..|.:.|:|..||.: ..|:::|.|||||.| |.:
Mouse  1189 H-PTHDRLFCVDIDECSIMNGGCETFCTNSDGSYECSCQPGFAL-MPDQRSCTDIDECEDNPNI- 1250

  Fly   213 WDCTAG-CKNLNGTYKCLPSLVGRVEPTDGDGFSPGEIVCKSGFKLSDDGSECQDINECDLADID 276
              |..| |.|:.|.|:||                     |..||..|:|...|.|:|||||
Mouse  1251 --CDGGQCTNIPGEYRCL---------------------CYDGFMASEDMKTCVDVNECDL---- 1288

  Fly   277 SDSWRMTYRYC-EHKCENTVGSYICHCPQGYH------LLDDQNSCILDGSKLPPSKDAPVSQEA 334
                  ....| ...||||.||:||||..||.      ...|.|.|.:.            :...
Mouse  1289 ------NPNICLSGTCENTKGSFICHCDMGYSGKKGKTGCTDINECEIG------------AHNC 1335

  Fly   335 PRKDICPLFKGPANGKASCDK-YLQNGFNYTRCNITCNAGYIM----------QGSQFAVC--GH 386
            .|..:|....|  :.|.||.. ::.:|...|..: .|:.|..|          .||...:|  |:
Mouse  1336 GRHAVCTNTAG--SFKCSCSPGWIGDGIKCTDLD-ECSNGTHMCSQHADCKNTMGSYRCLCKDGY 1397

  Fly   387 T--GLWSSPEAKCVESLALSCPVLTPPRNGRFYPASCNNEPSKSLAICELLCDRGYLPRMDTQLI 449
            |  |...:...:|.|:|.| |      .||:     |.|.|....  ||  ||.|::|..|.:..
Mouse  1398 TGDGFTCTDLDECSENLNL-C------GNGQ-----CLNAPGGYR--CE--CDMGFVPSADGKAC 1446

  Fly   450 -----CAAP 453
                 |:.|
Mouse  1447 EDIDECSLP 1455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32373	NP_001261534.1	FXa_inhibition	124..158	CDD:291342	8/38 (21%)
		vWFA	<158..199	CDD:294047	18/40 (45%)
		FXa_inhibition	287..315	CDD:291342	15/34 (44%)
		CCP	340..398	CDD:153056	16/72 (22%)
Fbn1	NP_032019.2	TB	1707..1751	CDD:366245
		EGF_CA	1768..>1799	CDD:214542
		EGF_CA	1810..1842	CDD:214542
		EGF_CA	1932..1973	CDD:311536
		EGF_CA	1975..2010	CDD:238011
		EGF_CA	2015..2055	CDD:389777
		TB	2072..2114	CDD:366245
		EGF_CA	2129..2167	CDD:214542
		EGF_CA	2168..2207	CDD:214542
		TB	2358..2393	CDD:366245
		vWFA	<2444..2484	CDD:381780
		cEGF	2467..2490	CDD:372248
		EGF_CA	2487..>2518	CDD:389777
		EGF_CA	2526..2568	CDD:214542
		EGF_CA	2569..>2598	CDD:214542
		EGF_CA	2609..2640	CDD:214542
		Fibrillin_U_N	48..82	CDD:375622
		TB	194..>228	CDD:366245
		EGF_CA	246..>276	CDD:214542
		EGF_CA	288..329	CDD:214542
		TB	344..389	CDD:366245
		EGF_CA	492..523	CDD:214542
		EGF_CA	532..573	CDD:214542
		EGF_CA	574..614	CDD:214542
		EGF_CA	615..648	CDD:214542
		TB	671..713	CDD:366245
		EGF_CA	725..765	CDD:389777
		EGF_CA	767..>798	CDD:214542
		cEGF	789..812	CDD:372248
		TB	863..>892	CDD:366245
		TB	968..1011	CDD:366245
		EGF_CA	1072..1106	CDD:214542	7/32 (22%)
		EGF_CA	1115..1151	CDD:214542	6/35 (17%)
		EGF_CA	1157..1192	CDD:238011	8/49 (16%)
		FXa_inhibition	1203..1238	CDD:373209	13/35 (37%)
		EGF_3	1328..1363	CDD:372403	8/48 (17%)
		EGF_3	1369..1404	CDD:372403	9/34 (26%)
		cEGF	1428..1451	CDD:372248	7/26 (27%)
		EGF_CA	1448..1488	CDD:214542	2/8 (25%)
		EGF_CA	1489..1520	CDD:214542
		TB	1551..1592	CDD:366245
		EGF_CA	1608..1640	CDD:214542
		EGF_CA	1650..1689	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BA2W
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900