DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32373 and si:dkey-163f14.6

DIOPT Version :9

Sequence 1:	NP_001261534.1	Gene:	CG32373 / 318000	FlyBaseID:	FBgn0052373	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	XP_009304399.1	Gene:	si:dkey-163f14.6 / 100332398	ZFINID:	ZDB-GENE-141215-18	Length:	740	Species:	Danio rerio

Alignment Length:	279	Identity:	86/279 - (30%)
Similarity:	119/279 - (42%)	Gaps:	65/279 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 YSCRVNYKLKRAKDNALYCS-NGIWLGLKPNCIKIGKGNTHSMKQKKMRCRIDNGGCAHICNRST 139
            |:|...|.| .:.|...||. :|.|.|..|.|:::            ..|.:.||||:.||..:.
Zfish   491 YACYPGYTL-TSGDVYSYCEHDGQWSGQTPLCLEL------------TPCSLHNGGCSQICRVNE 542

  Fly   140 H---KCECYEGYTLNSTDLRSCNDIDECKESNGGCSQVCNNLPGEFICTCNSGFEIDESDEKTCL 201
            |   :|.|..|:.| ..|.|:|.|:|||.|....|.|.|.|..|.:.|:|:.||:: .:|..:|.
Zfish   543 HHRAQCVCKPGFLL-LEDQRTCRDLDECVEELHLCQQACENTLGSYRCSCSPGFQL-SADGTSCS 605

  Fly   202 DIDEC--ADPELSWDCTAGCKNLNGTYKCLPSLVGRVEPTDGDGFSPGEIVCKSGFKLSDDGSEC 264
            |:|||  ....|   |..||.|..|:::||                     |..|.:|......|
Zfish   606 DVDECQLVGRAL---CEFGCINTPGSFQCL---------------------CAEGHQLDSTNRHC 646

  Fly   265 QDINECDLADIDSDSWRMTYRYCEHKCENTVGSYICHCPQGY------HLLDDQNSCIL-DGSKL 322
            .|||||:...:         ..||.||.|..|:|.|.||:||      |..:|.|.|.| :||
Zfish   647 IDINECEEEQL---------HMCEWKCVNLPGTYKCICPRGYRLHSNRHQCEDINECELKNGS-- 700

  Fly   323 PPSKDAPVSQEAPRKDICP 341
              .....::.....|..||
Zfish   701 --CSHLCINHRGDYKCACP 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32373	NP_001261534.1	FXa_inhibition	124..158	CDD:291342	14/36 (39%)
		vWFA	<158..199	CDD:294047	16/40 (40%)
		FXa_inhibition	287..315	CDD:291342	15/33 (45%)
		CCP	340..398	CDD:153056	2/2 (100%)
si:dkey-163f14.6	XP_009304399.1	CCP	28..79	CDD:153056
		CCP	83..133	CDD:214478
		CCP	461..521	CDD:214478	11/30 (37%)
		FXa_inhibition	527..563	CDD:291342	14/36 (39%)
		EGF_CA	565..604	CDD:284955	15/39 (38%)
		EGF_CA	606..647	CDD:214542	15/64 (23%)
		EGF_CA	648..689	CDD:214542	18/49 (37%)
		FXa_inhibition	694..730	CDD:291342	7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I12071
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17329
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940