DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG32373 and egf

DIOPT Version :9

Sequence 1:	NP_001261534.1	Gene:	CG32373 / 318000	FlyBaseID:	FBgn0052373	Length:	486	Species:	Drosophila melanogaster
Sequence 2:	NP_001106478.1	Gene:	egf / 100127663	XenbaseID:	XB-GENE-951823	Length:	1051	Species:	Xenopus tropicalis

Alignment Length:	377	Identity:	95/377 - (25%)
Similarity:	133/377 - (35%)	Gaps:	107/377 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 IKNAKASVKLRRNGEHVFLVT------YYSCRVNYKLKRAKDNALYCSNGIWLGLKPNCIKIGKG 112
            :||.:.|.|.     ||..|:      |||.|.:..:|..  |.....:.:.:.|||:.::|...
Frog   243 VKNLRLSTKY-----HVLGVSLLYNHIYYSERKSGSIKVI--NKFTGKDIVSVNLKPSIMEIRNI 300

  Fly   113 N-----------THSMKQKKMRCRIDNGGCAHIC--NRSTHKCECYEGYTLNSTDLRSCNDIDEC 164
            .           ..|..|....|.|.|..|...|  :....||.|..|:.|:|.. |.|.||:||
Frog   301 KVVYPVRSYSIPNSSSNQGAKSCSISNKHCTKTCEIDAENQKCHCMNGFVLSSNG-RYCEDINEC 364

  Fly   165 KESNGGCSQVCNNLPGEFICTCNSGFEIDESDEKTCLDIDECADPELSWDCTAGCKNLNGTYKCL 229
            ...|.||:..|.|:||.:.|||..|:.: ..|.|||.|...|....:  :|:.||
Frog   365 ALWNHGCTLGCENIPGSYFCTCPEGYVL-LPDNKTCHDKTPCLTEHI--ECSHGC---------- 416

  Fly   230 PSLVGRVEPTDGDGFSPGEIVCKSGFKLSDDGSECQDINECDLADIDSDSWRMTYRYCEHKC-EN 293
                  |:.|.|.     ...|..|..||:||..|......|...            |.|.| .:
Frog   417 ------VQTTKGP-----LCTCPEGSVLSEDGKSCTGCTSPDNGG------------CSHICIMS 458

  Fly   294 TVGSYICHCPQGYHLLDDQNSCILDGSKLPPSKDAPVSQEAPRKDICPLFKGPANGKASCDKYLQ 358
            ..|::.|.|..||:|..|:..|:..|.:       |....|...||..:.....|.::..|..:
Frog   459 GPGTWECDCFPGYNLQLDRKQCLASGPR-------PYLMFANVHDIRRINFDGTNYESVLDSQI- 515

  Fly   359 NGFNYTRCNITCNAGYIMQGSQFAV----------CGHTGLWSSPEAKCVES 400
                               |..||:          ..||.|      ||:||
Frog   516 -------------------GRVFALDYDPVEDRMYFAHTAL------KCIES 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32373	NP_001261534.1	FXa_inhibition	124..158	CDD:291342	12/35 (34%)
		vWFA	<158..199	CDD:294047	17/40 (43%)
		FXa_inhibition	287..315	CDD:291342	10/28 (36%)
		CCP	340..398	CDD:153056	9/67 (13%)
egf	NP_001106478.1	LY	152..194	CDD:214531
		vWFA	<346..398	CDD:320736	21/53 (40%)
		FXa_inhibition	412..440	CDD:317114	12/48 (25%)
		FXa_inhibition	447..480	CDD:317114	11/44 (25%)
		LY	508..550	CDD:214531	11/61 (18%)
		LY	554..593	CDD:214531
		Ldl_recept_b	615..654	CDD:278487
		LY	638..680	CDD:214531
		EGF_3	810..838	CDD:315598
		EGF_3	851..880	CDD:315598
		EGF_3	886..>914	CDD:315598
		PHA02887	<927..>967	CDD:333467
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000