Protein Alignment Crag and dennd3a

DIOPT Version :9

• Sequence 1: NP_001162710.2
• Gene: Crag / 31800
• FlyBaseID: FBgn0025864
• Length: 1671
• Species: Drosophila melanogaster
• Sequence 2: XP_021323902.1
• Gene: dennd3a / 797970
• ZFINID: ZDB-GENE-091230-6
• Length: 1285
• Species: Danio rerio
• Alignment Length: 1119
• Identity: 214/1119 - (19%)
• Similarity: 358/1119 - (31%)
• Gaps: 406/1119 - (36%)

  Fly   100 IGVLYDGHERIM-----SDAEIVAETPGGRVANVNNSSAKTFLTYRRARADMPCNELVVTELCVI 159
            :||   .:||:.     .||:::.|      |.|....|..|:|     .|..||..|
Zfish    16 LGV---SNERLKELCPGKDADVLVE------AEVLQVHAPPFIT-----KDRSCNGGV------- 59

  Fly   160 VQSKGERAPHAFCLIYKTLNKGYVGSDVYLCYKKSMYRP----KHISYKPEILLRYPTFDHTDFP 220
              .:|. || ||..:.|..:          ..||...||    .:.|...|       .:....|
Zfish    60 --DQGV-AP-AFSRVQKRRS----------FKKKKRERPVSTLSNSSQASE-------SEELSVP 103

  Fly   221 LNL-CPSVPLFCLPMGASLEAWPHVNGTEKRKPISPVFSTFVLTVSDGTYKV---YGSALTFYED 281
            .|: ..::|..|.|.|..:        |.:.:..|..|..|.....:.|:.|   |...:.|.:|
Zfish   104 QNIDLIALPQLCFPDGLRI--------TNESREDSYHFLVFTDVFGNQTHGVVAQYCRPVQFQQD 160

  Fly   282 ---YDESKLSAEQKELLGWDEEFGAQHSLHMIKAICLLSHHPFGDT------------------- 324
               |.....:.|.|.             |:...:||::|.:|:.:.
Zfish   161 NVIYANGHRTNEHKR-------------LYTTFSICVISKYPYYNALRDCLSCFLFQMKTSRVSD 212

  Fly   325 FDKWLK-YLHRMVLYDVNIPIPVERYITQLLDEVPFPAPSIHL-----QLSSESNDRILLTQPED 383
            ||:.:| :..::.|    :|||              |:..:|:     .|..|...|:      |
Zfish   213 FDEQVKEFSAKLAL----VPIP--------------PSGPLHVVFNLRPLQIELPSRL------D 253

  Fly   384 SPLPRSGAGFHILLQNLGTDNCLHVLLLALTEQKILIHSLRPATLTAVAEAIVSLLFPFKWQCPY 448
            ...|......|:..........|.::...|.||:::..|...|.||.|:|..:..:.|.:||.|:
Zfish   254 VDRPVMDLDLHLPFLCFKPKQILQIISSILMEQRVVFLSTDWAKLTLVSECFMIFIHPLRWQHPF 318

  Fly   449 IPLCPLGLAEVLHAPLPYLIGVDS-RFFDLYEPPTDVTCIDLDTNNISLCESQRHLSPKL-LPKR 511
            :|:....:.:.:.||..||:|..: .|.::.|...|:..||:|...:|...|.|...|.: |..|
Zfish   319 VPVLSRQMLDFIMAPTAYLMGCHTYHFQEVAEEIEDLVLIDIDQGTVSSSTSDRFDLPDVPLAAR 383

  Fly   512 AARLLRQTLTELENAKPISYDSTNSLDRDIRKRKR--ELVLEQRIQEAFLLFMASILRGYRDFLV 574
            ...:.|....:|.....:...|:.:...|:|..:|  :..|...|....:..:.:|.....|||
Zfish   384 DCFIFRCGGLQLHYDLDVCGSSSQTDVNDLRAHRRLWQRKLNSSILNISMELIVNIFSEVCDFL- 447

  Fly   575 PISKAPSVGATDPSALFQLKAFLRSRDKSHQKFFELMMKTQMFIRFIEER------SFV------ 627
                      .....:|..:.||||||.:...|:..::.|.:|..|:.||      :|.
Zfish   448 ----------NYEHRVFNSEEFLRSRDSTDSAFYRKVLDTHIFHSFLRERLNRKNDAFTRMQLNI 502

  Fly   628 -------------------------SDGDHGLSFFDECAEKVG----NYDETPA----------- 652
                                     ...::||:      :::|    |..::.:
Zfish   503 RSETRRLKIMTESPRRPTMEEINRKHRAENGLN------KRLGMSMPNLADSRSLTVPIRQMSMM 561

  Fly   653 ----QLHLVDWDTGQNSERTKY-IFPPDSVTPAGSQPGGGGGGLAYNY-ENF------------- 698
                .|.:..|...:..:..|. .|||.               |||:| :|:
Zfish   562 SVRMPLQMGSWSPIKPVKTFKLPEFPPP---------------LAYHYVQNYYHDLIGQLDRSIS 611

  Fly   699 TLQPE---LL------------------------QSTKKTALSKFLQLQLNASLSPGSPI----- 731
            :..|:   ||                        ||..||.:..| ..||..:|....|:
Zfish   612 SASPDDSALLARYYYLRGLVNSVTGRHVDALADFQSLYKTDMEIF-PAQLLNTLVEALPVEEKRI 675

  Fly   732 -ARRT---------------------------------KHEIKLSQKMASRCQQHP--------- 753
             .|||                                 ||..|  :....|.|:..
Zfish   676 AERRTDLKRLMSRVRRENEKDRARLVDGGTVKRFELPKKHLQK--EDFVRRVQESGIVKDLETIK 738

  Fly   754 ---EAWSKYLLATCYSLYFLILPSMV--LDPR------HAGKEPEILRAAYDVLVRASRLK-ITC 806
               ||.:..:..:|.|:::|.|...|  :||.      :..||.|  .||.||.:.|..|: :..
Zfish   739 RLFEALTLGVEDSCRSVFYLELDGQVKQVDPETFRFFYNFWKETE--AAAQDVDLPAVVLEHLEN 801

  Fly   807 DEFCYRIMMQLCGIHNL-------------------------------------PVLAVRLHYLM 834
            ||..|::...:...|.:                                     |.|.:|:..|.
Zfish   802 DECVYKVSSSVKTSHGVGKIAMTQRRLFLLTEGRPGYVEITKFRDIEDVRISSAPFLLLRIPSLK 866

  Fly   835 KRSGVQANALTYGFYNRC-----VLESQWP--------QDSTTISQIRWNR-IKNVVLGAAQFRK 885
            .|:.::..:......:.|     :::..|.        :|...:.|...|. :.:.|:|:.|.:|
Zfish   867 IRTSLRRESFEANLKSECDLWHLMIKEMWAGRKMADQHKDPQFMEQALTNALLMDAVVGSLQSQK 931

  Fly   886 A----------GKQRA--------------ASKVNKSLSASQDQNLSTLETVDGQSRTSLASSSG 926
            |          .|.::              ..|:|.||..:..|.:..|....||    |..|..
Zfish   932 AIYAATKLAYFDKMKSEVPMMVPKTTSDTLKHKINPSLDQTSPQAVDVLLYTPGQ----LGVSDV 992

  Fly   927 DGGGHGLLDFAAFD 940
            ||||:..|..|..|
Zfish   993 DGGGNPKLWCALSD 1006

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Crag	NP_001162710.2	uDENN	189..279	CDD:214824	19/97 (20%)
		DENN	308..492	CDD:307995	45/209 (22%)
		dDENN	551..624	CDD:129037	16/72 (22%)
		PPR repeat	808..837	CDD:276811	7/65 (11%)
dennd3a	XP_021323902.1	DENN	177..363	CDD:307995	45/209 (22%)
		dDENN	425..487	CDD:129037	16/72 (22%)
		WD40	997..1283	CDD:330360	3/10 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574193
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12296
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840