Protein Alignment Crag and DENND4C

DIOPT Version :9

• Sequence 1: NP_001162710.2
• Gene: Crag / 31800
• FlyBaseID: FBgn0025864
• Length: 1671
• Species: Drosophila melanogaster
• Sequence 2: NP_001317569.1
• Gene: DENND4C / 55667
• HGNCID: 26079
• Length: 1958
• Species: Homo sapiens
• Alignment Length: 2069
• Identity: 666/2069 - (32%)
• Similarity: 979/2069 - (47%)
• Gaps: 512/2069 - (24%)

  Fly     1 MEEK--RIADYFVVAGMPENPQLLQENSFNDSGRLRAATT--IEPITDIGVYFPLLGEEVPEGYE 61
            :|:|  |:.|||||||:.:...||.:    :..||...:|  ..|||||.:.....||.|||||.
Human     2 IEDKGPRVTDYFVVAGLTDTSTLLDQ----EINRLDTKSTGPKAPITDIAIIIKSAGETVPEGYT 62

  Fly    62 ILSHTPTGLQANLNHGSVRTTDCYIYFRRGKDRPPLVDIGVLYDGHERIMSDAEIVAETPGGRVA 126
            .:..||:.||||||:||:::.:.::.::||:|:|||.||||||:|.||::...|::..||.||.|
Human    63 CVEATPSALQANLNYGSLKSPELFLCYKRGRDKPPLTDIGVLYEGKERLIPGCEVILATPYGRCA 127

  Fly   127 NVNNSSA---KTFLTYRRARADMPCNELVVTELCVIVQSKGERAPHAFCLIYKTLNKGYVGSDVY 188
            ||||||.   :.|:|||||....|.|.|.||::||||.||||..||.||.:.|.||.|..||.|:
Human   128 NVNNSSTTSQRIFITYRRAPPVRPQNSLAVTDICVIVTSKGETPPHTFCKVDKNLNCGMWGSSVF 192

  Fly   189 LCYKKSMYRPKHISYKPEILLRYPTFDHTDFPLNLCPSVPLFCLPMGASLEAWPHVNGTEKRKPI 253
            ||||||:.....|:||..::.|||..|:..|||:. ..||||||||||::|.|    ..|.:.|:
Human   193 LCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLSE-SDVPLFCLPMGATIECW----DPETKYPL 252

  Fly   254 SPVFSTFVLTVSDGTYKVYGSALTFYEDYDESKLSAEQKELLGW---DEEFGAQHSLHMIKAICL 315
             |||||||||.|... ||||:|:.|||.|....||.:|...||.   .|......|::..|.|||
Human   253 -PVFSTFVLTGSSAK-KVYGAAIQFYEPYSRELLSEKQLMHLGLLTPVERKMVSKSINTNKCICL 315

  Fly   316 LSHHPFGDTFDKWLKYLHRMVLYDVNIPIPVERYITQLLDEVPFPAPS---IHLQLSSESNDRIL 377
            |||.||.:.|.|:|.:::::.:...: |:|:|::|:..:..:|||:|.   |.:|||  .:|.::
Human   316 LSHWPFFEAFRKFLMFIYKLSVSGPH-PLPIEKHISHFMQNIPFPSPQRPRILVQLS--VHDALI 377

  Fly   378 LTQPEDSPLPRSGAGFHILLQNLGTDNCLHVLLLALTEQKILIHSLRPATLTAVAEAIVSLLFPF 442
            |:||..:|||.|||.|..||.|||.:||..:||..|.|.|||:||||||.||.||||:|:::|||
Human   378 LSQPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPF 442

  Fly   443 KWQCPYIPLCPLGLAEVLHAPLPYLIGVDSRFFDLYEPPTDVTCIDLDTNNISLCESQRHLSPKL 507
            :|||||||||||.||.||.||||:::|||||:|||::||.||.|||||||.:.:.:.:::::.|.
Human   443 QWQCPYIPLCPLSLAAVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNMLYVSDEKKNMNWKQ 507

  Fly   508 LPKRAARLLRQTLTEL---------ENAKPISYDSTNSLDRDIRKRKRELVLEQRIQEAFLLFMA 563
            |||:..:.|..||.:|         :..:..:.|.| .::.|...:|:...||..||||||.|||
Human   508 LPKKPCKNLLSTLKKLYPQLSSVHQKTQEGSAIDMT-PIEADFSWQKKMTQLEMEIQEAFLRFMA 571

  Fly   564 SILRGYRDFLVPISKAPSVGATDPSALFQLKAFLRSRDKSHQKFFELMMKTQMFIRFIEERSFVS 628
            |||:|||.:|.||::|||..||...:||..:.||:|||:::.||:.|:.|||:|||||||.||||
Human   572 SILKGYRTYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEECSFVS 636

  Fly   629 DGDHGLSFFDEC---------AEKVGNYD-ETPAQLHLVDWDTGQNSERTKYIFPPDSVTPAGSQ 683
            |.|.||:|||:|         .||....| ::.....|::.|..|.||.|.:|.||:       .
Human   637 DKDTGLAFFDDCIEKLFPDKGTEKTDKVDFDSAEDTRLIELDDSQKSEHTVFIMPPE-------P 694

  Fly   684 PGGGGGGLA--YNYENF-TLQPELLQSTKKTALSKFLQLQLNASLSPGSPI-ARRTKHEIKLSQK 744
            |...|..|:  |:|:.| .|..:|....::..|. |.:.....|::...|: |:|||.|||.:.|
Human   695 PPDDGKDLSPKYSYKYFPRLDLKLFDRPQELKLC-FSRHPTGNSITKSPPLMAKRTKQEIKTAHK 758

  Fly   745 MASRCQQHPEAWSKYLLATCYSLYFLILPSMVLDPRHAGKEPEILRAAYDVLVRASRLKI-TCDE 808
            :|.||..:|..|:|.|.:.||||:|:.||:.|   |.:..:...|:.|||||::..:..: ..||
Human   759 LAKRCYTNPPQWAKCLFSHCYSLWFICLPAYV---RVSHPKVRALQQAYDVLIKMRKTDVDPLDE 820

  Fly   809 FCYRIMMQLCGIHNLPVLAVRLHYLMKRSGVQANALTYGFYNRCVLESQWPQDSTTISQIRWNRI 873
            .|||::|||||:...||||||:.:.||.:.::.||:|||:||:.||||.|| .||......|.::
Human   821 VCYRVVMQLCGLWGHPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWP-SSTRSGIFLWTKV 884

  Fly   874 KNVVLGAAQFRKAGKQRAASKVNKSLSASQDQNLSTLETVDGQSRTSLASSSGDGGGHGLLD--- 935
            :|||.|.||||:        .:.|::..||..::|.|:.|.|       .|.||...||.:|
Human   885 RNVVRGLAQFRQ--------PLKKTVQRSQVSSISALQNVTG-------GSDGDTVSHGSVDSSN 934

  Fly   936 ------FAAFDRLRNKLGSIVRQTVTGGNNE----TMGDAV-NNTGLLIPGELSA---------- 979
                  ...|.|...:|.||...:.|||.::    :..:.: ::..:.:|.|.:|
Human   935 DANNGEHTVFVRDLIRLESIDNHSSTGGQSDQGYGSKDELIKDDAEIHVPEEQAARELITKTKMQ 999

  Fly   980 --------------------PNTPT---------------------------------------- 984
                                |::||
Human  1000 TEEVCDASAIVAKHSQPSPEPHSPTEPPAWGSSIVKVPSGIFDVNSRKSSTGSISNVLFSTQDPV 1064

  Fly   985 ---------------------------------------------------------YGGDTEIL 992
                                                                     .|.|.:||
Human  1065 EDAVFGEATNLKKNGDRGEKRQKHFPERSCSFSSESRAGMLLKKSSLDSNSSEMAIMMGADAKIL 1129

  Fly   993 AKALQQQQPRKQIMSIGGGDDDDEDEDE--DEYTAGSPST----------------PQKQLEAGA 1039
            ..||  ..|:..::.|......:.....  |..|..|.||                .|:.||...
Human  1130 TAAL--TCPKTSLLHIARTHSFENVSCHLPDSRTCMSESTWNPEHRSSPVPEMLEESQELLEPVV 1192

  Fly  1040 DDL--EYAGGGDYE---ADEEDEDEVDEHVAAQRARQRVQS---PTKISPRTPV-TQNDPLGALN 1095
            ||:  ..|....||   :|.......|....::..|.:..|   ..|:..|..| |..|||..|
Human  1193 DDVPKTTATVDTYESLLSDSNSNQSRDLKTVSKDLRNKRSSLYGIAKVVQREDVETGLDPLSLL- 1256

  Fly  1096 EEESAASATPTQETQQEQ----QHSQSQIDSSIYSDKPILFRGQRSATFDESTQIGKSMHRSETM 1156
            ..|.....||..|.:...    ::...:|:|.:....|:   |.:|::.:        :||.|.
Human  1257 ATECTGGKTPDSEDKLFSPVIARNLADEIESYMNLKSPL---GSKSSSME--------LHREEN- 1309

  Fly  1157 PVASSGVTNSLAN----------------------------IGSSLKFT--FGRYSPARLSLKKD 1191
              ..||:|.:..:                            :..|..||  |.:.:|:|...::.
Human  1310 --RESGMTTAFIHALERRSSLPLDHGSPAQENPESEKSSPAVSRSKTFTGRFKQQTPSRTHKERS 1372

  Fly  1192 LKLPANIIE----NISSISPSLTGKKSNELIQGS-----LSSIKSAANSLTKKFDEIKGVISANS 1247
            ..|.|.:..    ::.|:..||:|.|.:.::.|.     .|.:|.||...:|.:..:....|.:.
Human  1373 TSLSALVRSSPHGSLGSVVNSLSGLKLDNILSGPKIDVLKSGMKQAATVASKMWVAVASAYSYSD 1437

  Fly  1248 TPTKTNNGH-HPHGLHHGHHHPHHHHHHHSQHGNAEQEEHDAAVHEEGKLRRVSSDLDPWGRLSE 1311
            ...:||..: .|.||                      |:|           .:..::.|
Human  1438 DEEETNRDYSFPAGL----------------------EDH-----------ILGENISP------ 1463

  Fly  1312 SRKSSYNNLVP---------LGENSSTGALHMHAFPA--VP-------------DNLYSL-TSEN 1351
              .:|.:.|||         ||.:||:|.:....:|.  ||             |:..|. ||.:
Human  1464 --NTSISGLVPSELTQSNTSLGSSSSSGDVGKLHYPTGEVPFPRGMKGQDFEKSDHGSSQNTSMS 1526

  Fly  1352 AADRDCDVLIQLTTCSQCHNCSVLVYDEEIMSGWTAEDSNLNTTCHACNKLTVPFLSVQIERQ-- 1414
            :..::|.:.:.:::||||..|..||||||||:||||:||||||.|..|....:|.|:::.:..
Human  1527 SIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTACPFCKSNFLPLLNIEFKDLRG 1591

  Fly  1415 -----VEESEQSDPLQDGKEQIANGN-SHK----------------------------------- 1438
                 ::.|...|.||.|...:||.: .||
Human  1592 SASFFLKPSTSGDSLQSGSIPLANESLEHKPVSSLAEPDLINFMDFPKHNQIITEETGSAVEPSD 1656

  Fly  1439 -------------------------TSLT------------------------------------ 1442
                                     .|||
Human  1657 EIKRASGDVQTMKISSVPNSLSKRNVSLTRSHSVGGPLQNIDFTQRPFHGISTVSLPNSLQEVVD 1721

  Fly  1443 ------------VPYLNPLVLRKELENILTQEGDIALIKPEFVDEHPIIYWNLLWLMERIESKTH 1495
                        ||||:|||||||||::|..|||..:....|:::||||:|||:|...|::..::
Human  1722 PLGKRPNPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSN 1786

  Fly  1496 LPELCLPVPSDKEHID-----PLSKV----KTVHIQCLWDNLSLHTEASGPPMYLLYRETQPTSP 1551
            ||.|.|    ..||.:     |||.:    |.|:||.||||::||.|.. .|:|:.:|..  .|.
Human  1787 LPGLIL----TSEHCNEGVQLPLSSLSQDSKLVYIQLLWDNINLHQEPR-EPLYVSWRNF--NSE 1844

  Fly  1552 LIKALLTDQAQLNKNVIQQIISAIRCNDFATPLKRLANERHKLKSNGVERSHSFYRDILFLALTA 1616
            ...:||:::.|....:::.|..:|:.|:...|:..|:.:    ...|::|..|.||:||||:|.:
Human  1845 KKSSLLSEEQQETSTLVETIRQSIQHNNVLKPINLLSQQ----MKPGMKRQRSLYREILFLSLVS 1905

  Fly  1617 IGRSNVDLATFHREYAAVFDKLTERECNMYYRNQDLPPSASTIFCRAYF-RPLL 1669
            :||.|:|:..|..||...::.|:. |.....:..|.|||||..:||..| .||:
Human  1906 LGRENIDIEAFDNEYGIAYNSLSS-EILERLQKIDAPPSASVEWCRKCFGAPLI 1958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Crag	NP_001162710.2	uDENN	189..279	CDD:214824	45/89 (51%)
		DENN	308..492	CDD:307995	101/186 (54%)
		dDENN	551..624	CDD:129037	43/72 (60%)
		PPR repeat	808..837	CDD:276811	17/28 (61%)
DENND4C	NP_001317569.1	uDENN	192..276	CDD:214824	45/90 (50%)
		DENN	309..492	CDD:396629	101/185 (55%)
		dDENN	559..632	CDD:129037	43/72 (60%)
		PPR repeat	820..849	CDD:276811	17/28 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141274
Domainoid	1	1.000	398	1.000	Domainoid score	I746
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1003	1.000	Inparanoid score	I294
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46628
OrthoDB	1	1.010	-	-		D47872at33208
OrthoFinder	1	1.000	-	-		FOG0001463
OrthoInspector	1	1.000	-	-		otm40932
orthoMCL	1	0.900	-	-		OOG6_102394
Panther	1	1.100	-	-	LDO	PTHR12296
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3728
SonicParanoid	1	1.000	-	-		X917
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.840