DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Crag and Dennd4c

DIOPT Version :9

Sequence 1:	NP_001162710.2	Gene:	Crag / 31800	FlyBaseID:	FBgn0025864	Length:	1671	Species:	Drosophila melanogaster
Sequence 2:	XP_006538085.1	Gene:	Dennd4c / 329877	MGIID:	1914769	Length:	1955	Species:	Mus musculus

Alignment Length:	2070	Identity:	685/2070 - (33%)
Similarity:	977/2070 - (47%)	Gaps:	517/2070 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEEK--RIADYFVVAGMPENPQLL-QENSFNDSGRLRAATTIEPITDIGVYFPLLGEEVPEGYEI 62
            :|:|  |:.|||||||:.:...|| ||.:..|:..:....   |||||.|.....||.|||||..
Mouse     2 IEDKGPRVTDYFVVAGLTDTSTLLDQEINRTDTNSIGPKA---PITDIAVIIKSAGETVPEGYTC 63

  Fly    63 LSHTPTGLQANLNHGSVRTTDCYIYFRRGKDRPPLVDIGVLYDGHERIMSDAEIVAETPGGRVAN 127
            :..||:.||||||:||:::.:.::.:|||:|:|||.||||||:|.||:|...|::..||.||.||
Mouse    64 VEATPSALQANLNYGSLKSPELFLCYRRGRDKPPLTDIGVLYEGKERLMPGCEVIQATPYGRCAN 128

  Fly   128 VNNSSA---KTFLTYRRARADMPCNELVVTELCVIVQSKGERAPHAFCLIYKTLNKGYVGSDVYL 189
            |||||.   :.|:|||||......|.|.||::|||:.||||..||.||.:.|.||.|..||:|:|
Mouse   129 VNNSSTTSQRIFITYRRAPPVRSQNSLAVTDICVIITSKGETPPHTFCKVDKNLNCGMWGSNVFL 193

  Fly   190 CYKKSMYRPKHISYKPEILLRYPTFDHTDFPLNLCPSVPLFCLPMGASLEAW-PHVNGTEKRKPI 253
            |||||:.....|:||..::.|||..|:..|||:  ||||||||||||::|.| |.:     :.|:
Mouse   194 CYKKSVPASNAIAYKAGLIFRYPEEDYESFPLS--PSVPLFCLPMGATIECWDPQI-----KYPL 251

  Fly   254 SPVFSTFVLTVSDGTYKVYGSALTFYEDYDESKLSAEQKELLG---WDEEFGAQHSLHMIKAICL 315
             |||||||||.|... ||||:|:.|||.|.:.:|:.:|...||   ..|:......::..|.|||
Mouse   252 -PVFSTFVLTGSSAE-KVYGAAIQFYEPYSQERLTEKQLTQLGLLTLVEKRVVSKPINSNKCICL 314

  Fly   316 LSHHPFGDTFDKWLKYLHRMVLYDVNI----PIPVERYITQLLDEVPFPAPS---IHLQLSSESN 373
            |||.||.:.|..:|     |.:|.|::    |:|:|::|:..:..:|||:|.   |.:|||  .:
Mouse   315 LSHWPFFEAFKNFL-----MFIYKVSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILIQLS--VH 372

  Fly   374 DRILLTQPEDSPLPRSGAGFHILLQNLGTDNCLHVLLLALTEQKILIHSLRPATLTAVAEAIVSL 438
            |..:|:||..:|||.|||.|..||.|||.:||..:|||.|.|.|||:||||||.||.||||:|::
Mouse   373 DAFILSQPVSTPLPLSGANFSSLLMNLGPENCATLLLLVLLESKILLHSLRPAVLTGVAEAVVAM 437

  Fly   439 LFPFKWQCPYIPLCPLGLAEVLHAPLPYLIGVDSRFFDLYEPPTDVTCIDLDTNNISLCESQRHL 503
            :|||:|||||||||||.||.||.||||:::|||||:|||::||.||.|||||||.:.:.:.::::
Mouse   438 IFPFQWQCPYIPLCPLSLAGVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNTLYVADERKNI 502

  Fly   504 SPKLLPKRAARLLRQTLTEL------ENAKP--ISYDSTNSLDRDIRKRKRELVLEQRIQEAFLL 560
            :.|.||||..:.|..||..|      .:.||  .|......::.|...:|:...||..|||.||.
Mouse   503 NWKQLPKRPCKSLLGTLRRLYQQLCSVHRKPQESSAIEMTPIEADYSWQKKMTQLEMEIQETFLR 567

  Fly   561 FMASILRGYRDFLVPISKAPSVGATDPSALFQLKAFLRSRDKSHQKFFELMMKTQMFIRFIEERS 625
            ||||||:|||.:|.||::|||..||...:||..:.||:|||:::.||:.|:.|||:|||||||.|
Mouse   568 FMASILKGYRSYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYTKFYTLLSKTQIFIRFIEECS 632

  Fly   626 FVSDGDHGLSFFDECAEKV---------GNYD-ETPAQLHLVDWDTGQNSERTKYIFPPDSVTPA 680
            ||||.|.||:|||:|.||:         ...| ::.....|::.|..|.||.|.:|.||:
Mouse   633 FVSDKDTGLAFFDDCIEKLFPDKGVERTEKVDLDSAEDTRLIELDDSQRSEHTVFIMPPE----- 692

  Fly   681 GSQPGGGGGGLA--YNYENF-TLQPELLQSTKKTALSKFLQLQLNASLSPGSPI-------ARRT 735
              .|...|..|:  |:|..| .|..:|..|.:|      |:|..|.. .|||.|       |:||
Mouse   693 --PPPDDGNNLSPQYSYTYFPRLDLKLFDSPQK------LKLCFNRH-PPGSSITNSPALMAKRT 748

  Fly   736 KHEIKLSQKMASRCQQHPEAWSKYLLATCYSLYFLILPSMVLDPRHAGKEPEILRAAYDVLVRAS 800
            |.|||.:.|:|.||..:|..|:|||.:.||||:|:.||:.|   |.:..:...|:.|:||||:..
Mouse   749 KQEIKTAHKLAKRCYTNPPQWAKYLFSHCYSLWFICLPAYV---RVSHPKVRALQQAHDVLVKMR 810

  Fly   801 RLKI-TCDEFCYRIMMQLCGIHNLPVLAVRLHYLMKRSGVQANALTYGFYNRCVLESQWPQDSTT 864
            :..: ..||.|||::|||||:...||||||:.:.||.:.::.||:|||:||:.||||.|| .||.
Mouse   811 KTDVDPLDEVCYRVVMQLCGLWVNPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWP-SSTR 874

  Fly   865 ISQIRWNRIKNVVLGAAQFRKAGKQRAASKVNKSLSASQDQNLSTLETVDGQSRTSLASSSGDGG 929
            .....|.:::|||.|.||||:..|:........|:||.|:               :...|.||..
Mouse   875 SGIFLWTKVRNVVHGLAQFRQPLKKTGQKSQVFSISAPQN---------------AACGSDGDTV 924

  Fly   930 GHGLLD---------FAAFDRLRNKLGSIVRQTVTGGNNET---MGDAVNNTGLLIPGELSAPNT 982
            .||.:|         ...|.|....|.||...:.|||.::.   ..|.:...|  ..|.....:|
Mouse   925 SHGSVDSSNDANNGEHTVFVRDLISLDSIDNHSSTGGQSDQGYGSKDELVKEG--ADGHAPEEHT 987

  Fly   983 PTYGGDTE-----------ILAKALQ----QQQPRK------QIMSIGGGDDDDEDEDEDEYTAG 1026
            |.....||           |::|.||    .|.|.:      .|:.:..|..|..:..    :.|
Mouse   988 PPELTTTELHIEEECDISAIVSKHLQPTPEPQSPTEPPAWGSSIVKVPSGLFDTNNRT----STG 1048

  Fly  1027 SPSTPQKQLEAGADDLEYAGGGDYEADEEDEDEVDEHV--------AAQRA-------------- 1069
            |.||.....:|..:|..::...:::.:.:..::..:|.        :..||
Mouse  1049 STSTVLFSTQAPVEDAVFSEVTNFKKNGDRGEKKQKHFPERSCSFSSESRAGMLLKKSSLDLNSS 1113

  Fly  1070 -------------------------------------------RQRVQSPTKISPR--TPVTQN- 1088
                                                       |.|:...|:.|..  :||.:.
Mouse  1114 EMAIMMGADAKILTAALTCPKTSPPHVTRTHSFENVNCHLADSRTRMSEGTRDSEHRSSPVLEML 1178

  Fly  1089 -------DPLGALNEEESAASATPTQETQQEQQHSQSQID------------SSIYS-------- 1126
                   :|:...|..|:||..  |..:.|...||....|            ||.|:
Mouse  1179 EESQELLEPVVGDNVAETAAEM--TCNSLQSNSHSDQSRDTQAGAQDPVNKRSSSYATRKAIERE 1241

  Fly  1127 ------------------------DK---PILFR----------------GQRSATFD---ESTQ 1145
                                    ||   |::.|                |.:|.:.:   |..|
Mouse  1242 DVETGLDPLSLLATECVEKTSDSEDKLFSPVISRNLADEIESYMNLKSPLGSKSCSMELHGEGNQ 1306

  Fly  1146 -------IGKSMHRSETM------PVASSGVTNSLANIGSSLKFTFGRY---SPARLSLKKDLKL 1194
                   ....:.||.::      |...|..|...:...||.|...||:   ||.|....:...|
Mouse  1307 EPGSPAVFAHPLERSSSLPSDRGPPARDSTETEKSSPAVSSSKTLTGRFKPQSPYRAYKDRSTSL 1371

  Fly  1195 PANI----IENISSISPSLTGKKSNELIQGS-----LSSIKSAANSLTKKFDEIKGVISANSTPT 1250
            .|.:    ..::.|:..||:|.|.:.::.|.     .||:|.||...:|.:..:....|.:....
Mouse  1372 SALVRSSPNSSLGSVVNSLSGLKLDNILSGPKIDVLKSSMKQAATVASKMWVAVASAYSYSDDEE 1436

  Fly  1251 KTNNGH-HPHGLHHGHHHPHHHHHHHSQHGNAEQEEHDAAVHEEGKLRRVSSDLDPWGRLSESRK 1314
            :||..: .|.||                      |:|..          |...|.|        .
Mouse  1437 ETNKDYSFPAGL----------------------EDHHI----------VGETLSP--------N 1461

  Fly  1315 SSYNNLVP---------LGENSSTGALHMHAFPA--VP-------------DNLYSL-TSENAAD 1354
            :|.:.|||         ||.:||:|.:.....||  ||             |:..|. ||.::..
Mouse  1462 TSVSGLVPSELTQSNTSLGSSSSSGDVGKLQCPAGEVPFSRNIKGQDFEKSDHGSSQNTSMSSIY 1526

  Fly  1355 RDCDVLIQLTTCSQCHNCSVLVYDEEIMSGWTAEDSNLNTTCHACNKLTVPFLSVQIERQ----- 1414
            ::|.:.:.:::||||..|..||||||||:||||:||||||||..|....:|.|:|:.:..
Mouse  1527 QNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTTCPFCKSNFLPLLNVEFKDLRGSAS 1591

  Fly  1415 --VEESEQSDPLQDG-------------------------------------------------- 1427
              ::.|...|.||.|
Mouse  1592 FFLKPSTSGDSLQSGSIPSASEPSEHKPTSSSAEPDLISFMDFSKHSETITEEASYTVESSDEIK 1656

  Fly  1428 -------------------KEQIANGNSHKTS--------------------------------- 1440
                               |..::...||...
Mouse  1657 KTNGDVQSVKMSSVPNSLSKRNVSLTRSHSVGGPLQNIDFSQRPFHGVSTVSLPSSLQEDVDHLG 1721

  Fly  1441 -------LTVPYLNPLVLRKELENILTQEGDIALIKPEFVDEHPIIYWNLLWLMERIESKTHLPE 1498
                   ::||||:|||||||||::|..|||..:....|:::||||:|||:|...|::..::||.
Mouse  1722 KRPSPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHPIIFWNLVWYFRRLDLPSNLPG 1786

  Fly  1499 LCLPVPSDKEHID-----PLSKV----KTVHIQCLWDNLSLHTEASGPPMYLLYR----ETQPTS 1550
            |.|    ..||.:     |||.:    |.|:||.||||::||.| .|.|:|:.:|    |.:|
Mouse  1787 LIL----TSEHCNGGVQLPLSSLSQDSKLVYIQLLWDNINLHQE-PGEPLYVSWRNLNSEKKP-- 1844

  Fly  1551 PLIKALLTDQAQLNKNVIQQIISAIRCNDFATPLKRLANERHKLKSNGVERSHSFYRDILFLALT 1615
                :||::|.|....:::.|..:|:.||...|:..|:.:    ...|.:|..|.||:||||:|.
Mouse  1845 ----SLLSEQQQAASALVETIRQSIQQNDVLKPINLLSQQ----MKPGTKRQRSLYREILFLSLV 1901

  Fly  1616 AIGRSNVDLATFHREYAAVFDKLTERECNMYYRNQDLPPSASTIFCRAYF-RPLL 1669
            ::||.|:|:..|..||...:..|.........| .|.|||.|..:||..| .||:
Mouse  1902 SLGRENIDIEAFDNEYGLAYRSLPSESLERLQR-IDAPPSISVEWCRKCFGAPLI 1955

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Crag	NP_001162710.2	uDENN	189..279	CDD:214824	47/90 (52%)
		DENN	308..492	CDD:307995	104/190 (55%)
		dDENN	551..624	CDD:129037	42/72 (58%)
		PPR repeat	808..837	CDD:276811	17/28 (61%)
Dennd4c	XP_006538085.1	uDENN	192..275	CDD:214824	47/91 (52%)
		DENN	308..491	CDD:366936	104/189 (55%)
		dDENN	558..631	CDD:129037	42/72 (58%)
		PPR repeat	819..848	CDD:276811	17/28 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831216
Domainoid	1	1.000	398	1.000	Domainoid score	I747
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	998	1.000	Inparanoid score	I296
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46628
OrthoDB	1	1.010	-	-		D47872at33208
OrthoFinder	1	1.000	-	-		FOG0001463
OrthoInspector	1	1.000	-	-		otm43003
orthoMCL	1	0.900	-	-		OOG6_102394
Panther	1	1.100	-	-	LDO	PTHR12296
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3728
SonicParanoid	1	1.000	-	-		X917
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.800