DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Crag and dennd5b

DIOPT Version :9

Sequence 1:	NP_001162710.2	Gene:	Crag / 31800	FlyBaseID:	FBgn0025864	Length:	1671	Species:	Drosophila melanogaster
Sequence 2:	XP_005164768.1	Gene:	dennd5b / 323528	ZFINID:	ZDB-GENE-030131-2248	Length:	1325	Species:	Danio rerio

Alignment Length:	946	Identity:	204/946 - (21%)
Similarity:	343/946 - (36%)	Gaps:	248/946 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 PCNELVVTELCVIVQSKGERAPHAFCLIYKTLNKGYVGSDVYLCYKKSMY--RPKHISYKPEILL 209
            ||.......:|.:....| ..|.|...:|:.|.....|.|.........:  .|...::|.::|.
Zfish    12 PCRFAHYFIVCGLDDETG-LEPDALAALYQWLEADRQGKDPEATAAGENFDQSPLKRTFKSKVLA 75

  Fly   210 RYP------TFDHTDFPLNLCPSVPLFCLPMGASLEAWPHVNGTEKRKPISPVFSTFVLTVSDGT 268
            .||      .||.        .:|.:.|:|.|.|...        :|..::|.|.:|::|..||:
Zfish    76 HYPENIECNPFDQ--------DAVNMLCMPKGLSFRT--------QRDSLAPHFHSFLITREDGS 124

  Fly   269 YKVYGSALTFYE----------------------------------------------------- 280
             :.||...||||
Zfish   125 -RTYGFVHTFYEEVTSPQICSAMQTLHQMHQAEHNTSAQNCTSSSSSSSSSSSSSSMDSLSSSLD 188

  Fly   281 DYDESKLSAEQKELLGWDEEFGAQHSLHMIKAICLLSHHPFGDTFDKWLKYLHRMVLYDVNIPIP 345
            |.|.......::...|:|   ..:.:|::.||:||::..||.....::|..:||.|......|:|
Zfish   189 DVDSPSAHGGRRTCEGYD---SIRDTLYVSKAMCLIAPMPFMHACKRFLAQMHRAVSCSPPPPLP 250

  Fly   346 VERYITQLLDEVPFPAPSIHLQLSSESNDRILLTQPEDSPLPRSGAGFHILLQNLGTDNCLHVLL 410
            :|.||..:|.|||.||....|:... ..:.||..:|....||.:........:.||.:|.:.:..
Zfish   251 LESYIYNVLYEVPLPASGRSLKFHG-VYEPILCQRPGVGELPLADFPLADAFRLLGVENLVQLFT 314

  Fly   411 LALTEQKILIHSLRPATLTAVAEAIVSLLFPFKWQCPYIPLCPLGLAEVLHAPLPYLIGVDSR-- 473
            ..|.|.:||::|.....|..|||.|.:|||||:||..|:|:.|..|...|.||:|||:|:.|:
Zfish   315 CVLLEMQILLYSQDYQRLMVVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEG 379

  Fly   474 --FFDLYEPPTDVTC-IDLDTNNISL----------CESQRHLSPKLL------------PKRAA 513
              ...|..|.....| :|:|.:.|.|          .|..:.||..||            |:.|.
Zfish   380 TDRSKLELPQEANLCFVDIDNHCIELPEDFPQFPNRSEFIQELSEVLLSFGQSPEGGSSSPEPAV 444

  Fly   514 RLLRQTLTELE----NAKPISYDSTN------SLD--------------RDIRKRK--------- 545
            ..|:.::.|.|    :.:.:..|.||      :||              :.:.||.
Zfish   445 MSLQTSVLEKELKSTSLRELVDDKTNGNLGGEALDVLELLQGNPTLERLQALAKRTGVKVARLEA 509

  Fly   546 ----------------------RELVLEQRIQEAFLLFMASILRGYRDFLVPISKAPSVGATDPS 588
                                  |...|..:::|.|....|::...|..|::..|.......|:..
Zfish   510 LAAGQKGDEGVGGRSPVEEEELRNAKLNVQLREVFAARFATMFADYESFVIQNSPDLESWLTNRE 574

  Fly   589 AL--FQLKAFLRSRDKSHQKFFELMMKTQMFIRFIEER--SFVSDGDHGLSFFDECAEKVGNYDE 649
            .:  |...:||..:.:.:..|....::||||..||:.:  |...:.:..|..||...||
Zfish   575 QMHNFDKASFLSDQPEPYLPFLSHFIETQMFATFIDNKIMSQWEEKEPLLRVFDGRIEK------ 633

  Fly   650 TPAQLHLVDWDTGQNSERTKYIFPPDSVTPAGSQPGGGGGGLAYNYENFTLQPELLQSTKKTALS 714
              |:|:.|...:.::|...|..|..:|......:        ....::..:.|.||.  .|....
Zfish   634 --ARLYNVRAPSLRSSVYQKCTFLKESAQAIEQR--------LRKIDHTAIHPHLLD--MKIGQG 686

  Fly   715 KFLQ---LQLNASLSPGSPIARRTKHEIKLSQKMASRCQQHPEAWSKYLLATCYSLYFLILPS-- 774
            |:.|   .:|.|.:....|.:.:..:....:|:...|.:|..|              .|:|.:
Zfish   687 KYQQGFFPKLQADVLASGPTSNKWSNRTCSTQRRVERHRQQNE--------------HLVLDNEL 737

  Fly   775 ---MVLDPRHAGK---EPEILRAAYDVLVRASRLKITCDEFCYRIMMQLCGIHNLPVLAVRLHYL 833
               .:.:.|:.||   :|::...:..|:.:      |..:|...::.: |.:..       ...|
Zfish   738 KEKYMQEARNLGKNLRQPKLSDLSPAVIAQ------TNWKFVEGLLKE-CKMKT-------KRML 788

  Fly   834 MKRSGVQANALTYGFYNRCVLESQWPQDSTTISQI------RWNRIKNVVLGAAQFRKAGKQRAA 892
            :::.|.:|..|.:|..|...||     ::|.|:.:      .|:....|        |.||....
Zfish   789 VEKMGREAVELGHGEANITGLE-----ENTLIASLCDLLERIWSHGLQV--------KQGKSALW 840

  Fly   893 SKVNKSLSASQDQNLSTLET--VDGQSRTSLASSSG 926
            |.: ....|.:::|...||:  .:||.|....||.|
Zfish   841 SHL-LHYQAREEKNEQQLESPVSNGQERRKTESSVG 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Crag	NP_001162710.2	uDENN	189..279	CDD:214824	22/97 (23%)
		DENN	308..492	CDD:307995	64/188 (34%)
		dDENN	551..624	CDD:129037	17/74 (23%)
		PPR repeat	808..837	CDD:276811	3/28 (11%)
dennd5b	XP_005164768.1	uDENN	12..134	CDD:214824	32/139 (23%)
		DENN	213..401	CDD:280329	64/188 (34%)
		dDENN	537..612	CDD:129037	17/74 (23%)
		RUN	817..961	CDD:295434	16/68 (24%)
		PLAT_RAB6IP1	973..1095	CDD:238855
		RUN	1178..1319	CDD:280855
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3728
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930