Protein Alignment Crag and Dennd5b

DIOPT Version :9

• Sequence 1: NP_001162710.2
• Gene: Crag / 31800
• FlyBaseID: FBgn0025864
• Length: 1671
• Species: Drosophila melanogaster
• Sequence 2: XP_006507126.1
• Gene: Dennd5b / 320560
• MGIID: 2444273
• Length: 1296
• Species: Mus musculus
• Alignment Length: 1147
• Identity: 239/1147 - (20%)
• Similarity: 372/1147 - (32%)
• Gaps: 407/1147 - (35%)

  Fly   198 PKHISYKPEILLRYP------TFDHTDFPLNLCPSVPLFCLPMGASLEAWPHVNGTEKRKPISPV 256
            |...::|.::|..||      .||.        .:|.:.|:|.|.|...  ..:..|      |.
Mouse    72 PLRRTFKSKVLAHYPQNIEWNPFDQ--------DAVNMLCMPKGLSFRT--QADNKE------PQ 120

  Fly   257 FSTFVLTVSDGTYKVYGSALTFYEDYDESKL-----------SAEQ------------KELLGWD 298
            |.:|::|..||: :.||..|||||:....::           :|||            ..|....
Mouse   121 FHSFIITREDGS-RTYGFVLTFYEEVTSKQICTAMQTLYQMHNAEQYSSVYASSSCSMDSLASSI 184

  Fly   299 EEFGA---------------QHSLHMIKAICLLSHHPFGDTFDKWLKYLHRMVLYDVNIPIPVER 348
            :|..|               :.:|::.|:|||::..||.....|:|..||:.|......|:|:|.
Mouse   185 DEGDATSLLKLQRYNSYDINRDTLYVSKSICLITPLPFMQACKKFLFQLHKAVTSQQPPPLPLES 249

  Fly   349 YITQLLDEVPFPAPSIHLQLSSESNDRILLTQPEDSPLPRSGAGFHILLQNLGTDNCLHVLLLAL 413
            ||..:|.|||.|.|...|:... ..:.::..:|..:.||.|........:.||.:|.:.|....|
Mouse   250 YIHNILYEVPLPPPGRSLKFYG-VYEPVICQRPGPNELPLSDYPLREACELLGLENLVQVFTCVL 313

  Fly   414 TEQKILIHSLRPATLTAVAEAIVSLLFPFKWQCPYIPLCPLGLAEVLHAPLPYLIGVDSR----F 474
            .|.:.|::|.....|..|||.|.:|||||:||..|:|:.|..|...|.||:|||:|:.|:    .
Mouse   314 LEMQTLLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEGTDR 378

  Fly   475 FDLYEPPTDVTC-IDLDTNNISLCES----------QRHLSPKLL------------PKRAARLL 516
            ..|..|.....| :|:|.:.|.|.|.          .:.||..||            .:.|.:|.
Mouse   379 SKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLLQFGIPPEGSLHSSESATKLK 443

  Fly   517 RQTLTELENAKPISYDSTNSL--------------------------------------DRDIRK 543
            ...|.:|.|.|.......||:                                      ::|::.
Mouse   444 NMVLKDLANDKKNGNVPNNSVSVYELLKGSETIARLQALAKRTGVTMEKIDLPASLSEKEKDLKL 508

  Fly   544 R-----KRELVLEQRIQEAFLLFMASILRGYRDFLVPISKAPSVGATDPSAL--FQLKAFLRSRD 601
            :     .|:..|..:::|.|......:...|..|::..::......|:...:  |...:||..:.
Mouse   509 QCEEADLRDSQLNVQLREVFANRFTQMFADYEAFVIQTAQDMESWLTNREQMQNFDKASFLSDQP 573

  Fly   602 KSHQKFFELMMKTQMFIRFIEER--SFVSDGDHGLSFFDECAEKVGNY----------------- 647
            :.:..|....::||||..||:.:  |...:.|..|..||...||:..|
Mouse   574 EPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDSRIEKIRLYNVRAPTLRTSIYQKCSS 638

  Fly   648 ---------------DETPAQLHLVDWDTGQNSERTKY---IFPPDSVTPAGSQPGGGG------ 688
                           |.|....||:|...||.    ||   .||........:.|....
Mouse   639 LKEAAQSIEQRLMKMDHTAIHPHLLDMKIGQG----KYEQGFFPKLQSDVLATGPANNNRWVSRS 699

  Fly   689 -------GGLAYNYENFTLQPELLQSTKKTA--LSKFLQLQLNASLSPGSPIAR----------- 733
                   ..|..:.|:..|..:|.:...:.|  |.|.|:....:.||| :.||:
Mouse   700 ATAQRRKERLRQSSEHIGLDSDLREKYMQEARSLGKNLRQPKLSDLSP-AVIAQTNWKFVEGLLK 763

  Fly   734 --RTKHEIKLSQKM-----------------------ASRCQQHPEAWSKYLLAT-------CYS 766
              |.|.:..|.:||                       ||.|......||..||..       .:.
Mouse   764 ECRMKTKRMLVEKMGHEAVELGHGEANITGLEENTLIASLCDLLERIWSHGLLVKQGKSALWSHL 828

  Fly   767 LYF---------------------------LILP----SMVLDPRHAGKEPEI----------LR 790
            |.|                           ::||    |::.|.||.....||          :|
Mouse   829 LQFQDREEKQEHLTDSPVALGPERRKSDSGVMLPTLRVSLIQDMRHIQNMTEIKTDVGRARAWIR 893

  Fly   791 AAYDVLVRASRLK------------------ITCDE----FCYRIMMQLCGIHNLPVLAVRLHYL 833
            .:.:..:.:..||                  :.|:|    |.|.::
Mouse   894 LSLEKKLLSQHLKQLLSNQPLTKKLYKRYAFLRCEEEREQFLYHLL------------------- 939

  Fly   834 MKRSGVQANALTYGFYNRCVLESQWPQDSTTISQIRWNRIKNVVL---------------GAAQF 883
                  ..||:.|..:.........|..|..|.   ..::.|.::               |..|.
Mouse   940 ------SLNAVDYFCFTSVFTTIMIPYRSVIIP---IKKLSNAIITSNPWICVSGELGDTGVMQI 995

  Fly   884 RKAGKQRAASKVNKSLSASQDQNLSTLETVD-GQSRTSLASSSGDGGGHGLLDFAAFDRLRNKLG 947
            .|          |......:.|||..|.||. |...:.|.:.       .|:|..
Mouse   996 PK----------NLLEMTFECQNLGKLTTVQIGHDNSGLLAK-------WLVDCV---------- 1033

  Fly   948 SIVRQTVTGGN-----NETMGDAVNNTGL--LIPGELSAPNTPTYGGDTEILAKAL----QQQQP 1001
             :||..:||..     ...:|..|::..|  ::.|||.     |...| |.|.|..    ||:.|
Mouse  1034 -MVRNEITGHTYRFPCGRWLGKGVDDGSLERILIGELM-----TSASD-EDLGKQCRTPPQQKSP 1091

  Fly  1002 ----RKQIMSIGGGDDDDEDEDEDEYTAGSPSTPQK-QLEAG 1038
                |..|.|:                .|.|:.|.. |::.|
Mouse  1092 TTTRRLSITSL----------------TGKPAKPNAGQIQEG 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Crag	NP_001162710.2	uDENN	189..279	CDD:214824	23/86 (27%)
		DENN	308..492	CDD:307995	64/188 (34%)
		dDENN	551..624	CDD:129037	15/74 (20%)
		PPR repeat	808..837	CDD:276811	3/32 (9%)
Dennd5b	XP_006507126.1	uDENN	19..142	CDD:214824	23/86 (27%)
		DENN	209..397	CDD:366936	64/188 (34%)
		dDENN	521..596	CDD:129037	15/74 (20%)
		RUN	802..946	CDD:367169	25/168 (15%)
		PLAT_RAB6IP1	958..1066	CDD:238855	25/138 (18%)
		RUN	1149..1286	CDD:383089

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900