Protein Alignment Crag and Dennd3

DIOPT Version :10

• Sequence 1: NP_525080.3
• Gene: Crag / 31800
• FlyBaseID: FBgn0025864
• Length: 1671
• Species: Drosophila melanogaster
• Sequence 2: NP_001414187.1
• Gene: Dennd3 / 315055
• RGDID: 1311559
• Length: 1278
• Species: Rattus norvegicus
• Alignment Length: 1429
• Identity: 264/1429 - (18%)
• Similarity: 463/1429 - (32%)
• Gaps: 450/1429 - (31%)

  Fly   177 TLNKGYVGSDVYLCYKKSMYRPKHISYKPEI-LLRYPTFDHTDFP--LNLCPSVPLFCLPMGASL 238
            ||:||...|     ::|...:|:..|:|... ..:.|..:....|  ::|. ::|..|.|.|..:
  Rat    73 TLSKGRRRS-----FRKKREKPRMESWKSHPGDSKGPDSEDVTIPGGVDLL-ALPQLCFPGGVCV 131

  Fly   239 EAWPHVNGTEKRKPISPVFSTFVLTVSDGTYKVYGSALTFYEDYDESKLSAEQKELLGWDEEFGA 303
            .:          :|........|||...|. :.||....:|....:.......|.  .|:....:
  Rat   132 AS----------EPKEDYIHFLVLTDVCGN-RTYGVVAQYYRPLHDEYCFYNGKS--HWEPSMSS 183

  Fly   304 QHSLHMIKAICLLSHHPFGDTFDKWLKYL--HRMVLYDVNIPIPVERYITQLLDEVPFPAPS-IH 365
            .... :..|:|::|..|:.::....|..|  |..:..|..:...::.:..: |..:|.|.|. :|
  Rat   184 ARRF-VPFAVCVVSRFPYYNSLKDCLSCLLTHLKLCKDFEVDNHIKDFAAR-LSLIPSPPPGPLH 246

  Fly   366 LQLSSESNDRILLTQPEDSPLPRSGAGFHILLQNLGTDNCLHVLLLALTEQKILIHSLRPATLTA 430
            |..:.:.. :::.....|...|......|:.|.....:..|.:|...||||:::..|...|.||.
  Rat   247 LIFNMKPL-QVVFPSRADPESPIIDLDLHLPLLCFRPEKVLQILTCILTEQRMVFFSSDWALLTL 310

  Fly   431 VAEAIVSLLFPFKWQCPYIPLCPLGLAEVLHAPLPYLIGVDSRFFDLYEPPTD-VTCIDLDTNNI 494
            :||..|:.:.|.:||..::|:....:.:.:.||..:|:|.....|:......| :..||:|..::
  Rat   311 MAECFVAYVHPLQWQHTFVPILSGQMLDFVMAPTSFLMGCHLDHFEEVRKEADGLVLIDIDLGSV 375

  Fly   495 SLCE-SQRHLSPKLLPKRAARLLRQTLTELENAKPISYDSTNSLDRDI-----RKRKRELVLEQR 553
            :..: |...:....:|...|:...|.:..|: ..|..:.:..|...|:     |:|..:..|..:
  Rat   376 TCSKSSDEDVDIPDVPLLLAQAFIQRVQSLQ-LHPDLHLAHLSASTDLNEGRARRRAWQQALNCK 439

  Fly   554 IQEAFLLFMASILRGYRDFLVPISKAPSVGATDPSALFQLKAFLRSRDKSHQKFFELMMKTQMFI 618
            ||...|..:..|.|..::.|           .....:|..:.||::|....|:|::.::.|.||.
  Rat   440 IQHITLQLLVGIFREVKNHL-----------NYEHRVFNSEEFLKTRAAGDQQFYKQVLDTYMFH 493

  Fly   619 RFIEERSFVSDGDHGLSFFDECAEKVGNYDETPAQLHLVDWDTGQNSERTKYIFPPDSVTPAGSQ 683
            .|::.|         |:         |..|    ....:|.||....:|
  Rat   494 SFLKAR---------LN---------GRMD----AFARMDLDTQSEEDR---------------- 520

  Fly   684 PGGGGGGLAYNYENFTLQPELLQSTKKTALSKFLQLQLNASLSPGSPIARRTKHEIKLSQKMASR 748
                                         :.:.|       :||..|..          :|||||
  Rat   521 -----------------------------IDRML-------ISPRRPTV----------EKMASR 539

  Fly   749 CQQHPEAWSKYLLATCYSLYFLILPSMVLDPRHAGKEPEILRAAYDVLVRASRLKITCDEFCYRI 813
            .........:.::.:..:|..:.||.  |.||:                  |.|:|.....|.
  Rat   540 KASPLNIAHRRMVVSMPNLQDISLPE--LPPRN------------------SSLRIMDTSSCK-- 582

  Fly   814 MMQLCGIHNLPVLAV-----------RLHYLMKRSGVQANALTYGFYNRCVLESQ-----WPQDS 862
                   .:.|||.|           .:|:.:....|||.     |.:...|.|:     .|.||
  Rat   583 -------SSSPVLKVTPKSTYTFKIPEIHFPLVSQCVQAY-----FTDLVTLLSKAMALLGPGDS 635

  Fly   863 TTISQIRWNRIKNVVLGAAQFRKAGKQRAASKVNKSLSASQDQNLSTLETVDGQS--RTSLASSS 925
            ..::  |:..::.::                      ...|.|.|:.|  :|.||  :|.:....
  Rat   636 LLLA--RYFYLRGLI----------------------HLMQGQLLNAL--LDFQSLYKTDIRIFP 674

  Fly   926 GDGGGHGLLD-FAAFDRLRNKLGSIVRQTVT-----GGNNETMGDAVNNTGLLIPGELSAPNTPT 984
            .| ...|::| .:|.:|.:.:....:|:.:|     .|....:.|||.|..|           |.
  Rat   675 AD-LVKGMVDSMSASERAQAERTPELRRLITEVFDKQGEAPKVDDAVKNFEL-----------PK 727

  Fly   985 YGGDTEILAKALQQQQPRK---------QIMSIGGGDDDDEDEDEDEYTAGSPSTPQKQLEAGAD 1040
            .........|.:|:....|         ..:::|.....|.:...|.||.      .|:.||.|.
  Rat   728 KHMQLNDFVKRVQESGIVKDTTIIHRLFDALTVGHEKQIDPETFRDFYTC------WKETEAEAQ 786

  Fly  1041 DLEYAGGGDYEADEEDEDEVDEHVAAQRARQRVQSPTKISPRTPVTQNDPLGALNEEESAASATP 1105
            ::....   ...|..|.:|               ...|:|  :.|..|..:|.:...:......|
  Rat   787 EVSLPA---LLVDHLDRNE---------------CVYKLS--SSVKTNRGVGKIAMTQKRLFLLP 831

  Fly  1106 TQETQQEQQHSQSQIDSSIYSDKPILFRGQRSATFD-----ESTQIGKSMHRSETM---PVASSG 1162
                  |.:.|..:|                 |||.     :||.:...:.:..|:   .||...
  Rat   832 ------EGRPSYVEI-----------------ATFRNIEEVKSTTVAFLLLKIPTLKIKTVAKKE 873

  Fly  1163 VTNSLANIGS--SLKFTFGRYSPARLSLKKDLKLPANIIENISSISPSLTGKKSNELIQGSLSSI 1225
            |..  ||:.|  .|.....:...|...|..|.|.|       ..:..:||.....:.:.|:|.|.
  Rat   874 VFE--ANLKSECDLWHLMVKEMWAGKKLADDHKDP-------QYVQQALTNVLLMDAVVGTLQSS 929

  Fly  1226 KS--AANSLTKKFDEIKGVISANSTP---TKTNNGHHPHGLHHGHHHPHHHHHHHSQHGNAEQEE 1285
            .:  ||:.|. .||::|     |..|   .||.:....|.:             :...|....:.
  Rat   930 GAIYAASKLA-YFDKMK-----NELPMAVPKTTSETLKHKI-------------NPSAGETAPQA 975

  Fly  1286 HDAAVHEEGKLRRVS--SDLDP--WGRLSESRKSSYNNLVPLGENSSTGALHMHAFPAVPDNLYS 1346
            .:..::..|:|....  .|..|  |..|:|.:...:        ::|:..:|.|.|......:
  Rat   976 IEVLLYTPGRLDPAEKVEDAHPKLWCALNEGKVVVF--------DASSWTIHQHCFKVGSSKV-- 1030

  Fly  1347 LTSENAADRDCDVLIQLTTCSQCHNCSVLVYDEEIMSGWTAEDS---NLNTTCHACNKLTVPFLS 1408
                                    ||.|:....::..|  :|||   .:|....:|||
  Rat  1031 ------------------------NCMVMAEHSQVWVG--SEDSVIYIINVHSMSCNK------- 1062

  Fly  1409 VQIERQVEESEQSDPLQDGKEQIANGNSHKTSLTVPYLNPLVLRKELENILTQEGDIALIKPEFV 1473
                                 |:.:..|..|.|.||                 .|.    ||..|
  Rat  1063 ---------------------QLTDHRSAVTGLAVP-----------------SGK----KPSAV 1085

  Fly  1474 D----EHPIIYWNLLWLMERIESKTHLPELCLPVPSDKEHIDPLSKVKTVHIQCLWDNLSLHTE 1533
            .    :..::.||:..|  |:.|:..|           :|.|.:|             :|||.:
  Rat  1086 YSCSLDGTVLAWNVSTL--RVISRFQL-----------QHGDLMS-------------ISLHND 1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Crag	NP_525080.3	uDENN	189..279	CDD:214824	18/92 (20%)
		DENN	308..492	CDD:460461	44/187 (24%)
		dDENN	551..624	CDD:129037	16/72 (22%)
		PPR repeat	808..837	CDD:276811	6/39 (15%)
Dennd3	NP_001414187.1	None