Protein Alignment Crag and Dennd4c

DIOPT Version :9

• Sequence 1: NP_001162710.2
• Gene: Crag / 31800
• FlyBaseID: FBgn0025864
• Length: 1671
• Species: Drosophila melanogaster
• Sequence 2: XP_038967015.1
• Gene: Dennd4c / 313340
• RGDID: 1308489
• Length: 1951
• Species: Rattus norvegicus
• Alignment Length: 2087
• Identity: 667/2087 - (31%)
• Similarity: 968/2087 - (46%)
• Gaps: 555/2087 - (26%)

  Fly     1 MEEK--RIADYFVVAGMPENPQLLQENSFNDSGRLRAATTI---EPITDIGVYFPLLGEEVPEGY 60
            :|:|  |:.|||||||:.:...||.:    :..|:....:|   .|||||.|.....||.|||||
  Rat     2 IEDKGPRVTDYFVVAGLTDTSTLLDQ----EINRIDTNKSIGPKAPITDIAVIIKSAGETVPEGY 62

  Fly    61 EILSHTPTGLQANLNHGSVRTTDCYIYFRRGKDRPPLVDIGVLYDGHERIMSDAEIVAETPGGRV 125
            ..:..||:.||||||:||:::.:.::.:|||:|:|||.||||||:|.||::...|::..||.||.
  Rat    63 TCVEATPSALQANLNYGSLKSPELFLCYRRGRDKPPLTDIGVLYEGKERLIPGCEVIQATPYGRC 127

  Fly   126 ANVNNSSA---KTFLTYRRARADMPCNELVVTELCVIVQSKGERAPHAFCLIYKTLNKGYVGSDV 187
            |||||||.   :.|:|||||......|.|.||::|||:.||||..||.||.:.|.||.|..||:|
  Rat   128 ANVNNSSTTSQRIFITYRRAPPVRSQNSLAVTDICVIITSKGETPPHTFCKVDKNLNCGMWGSNV 192

  Fly   188 YLCYKKSMYRPKHISYKPEILLRYPTFDHTDFPLNLCPSVPLFCLPMGASLEAWPHVNGTEKRKP 252
            :||||||:.....|:||..::.|||..|:..|||:  .|||||||||||::|.|    ..:.:.|
  Rat   193 FLCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLS--ESVPLFCLPMGATIECW----DPQTKYP 251

  Fly   253 ISPVFSTFVLTVSDGTYKVYGSALTFYEDYDESKLSAEQKELLGW---DEEFGAQHSLHMIKAIC 314
            : |||||||||.|... ||||:|:.|||.|....|:.:|...||.   .|.......::..|.||
  Rat   252 L-PVFSTFVLTGSSAE-KVYGAAIQFYEPYSRDLLTEKQLSQLGLLTPVERKVVSKPINSNKCIC 314

  Fly   315 LLSHHPFGDTFDKWLKYLHRMVLYDVNI----PIPVERYITQLLDEVPFPAPS---IHLQLSSES 372
            ||||.||.:.|.|:|     |.:|.|::    |:|:|::|:..:..:|||:|.   |.:|||  .
  Rat   315 LLSHWPFFEAFKKFL-----MFIYKVSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILVQLS--V 372

  Fly   373 NDRILLTQPEDSPLPRSGAGFHILLQNLGTDNCLHVLLLALTEQKILIHSLRPATLTAVAEAIVS 437
            :|.::|:||..:|||.|||.|..||.|||.:||..:|||.|.|.|||:||||||.||.||||:|:
  Rat   373 HDALILSQPVSTPLPLSGANFSSLLMNLGPENCATLLLLVLLESKILLHSLRPAVLTGVAEAVVA 437

  Fly   438 LLFPFKWQCPYIPLCPLGLAEVLHAPLPYLIGVDSRFFDLYEPPTDVTCIDLDTNNISLCESQRH 502
            ::|||:|||||||||||.||.||.||||:::|||||:|||::||.||.|||||||.:.:.:.:::
  Rat   438 MIFPFQWQCPYIPLCPLSLAGVLSAPLPFIVGVDSRYFDLHDPPQDVVCIDLDTNTLYVADEKKN 502

  Fly   503 LSPKLLPKRAARLLRQTLTEL------ENAKP--ISYDSTNSLDRDIRKRKRELVLEQRIQEAFL 559
            .:.|.|||:..:.|..||.:|      .:.||  .|......::.|...:|:...||..|||.||
  Rat   503 TNWKQLPKKPCKSLLGTLRKLYLQLCSVHRKPQESSAIEMTPIEADFSWQKKMTQLEMEIQETFL 567

  Fly   560 LFMASILRGYRDFLVPISKAPSVGATDPSALFQLKAFLRSRDKSHQKFFELMMKTQMFIRFIEER 624
            .||||:|:|||.:|.||::|||..||...:||..:.||:|||:::.||:.|:.|||:|||||||.
  Rat   568 RFMASVLKGYRSYLRPITEAPSNKATAADSLFDRQGFLKSRDRAYTKFYTLLSKTQIFIRFIEEC 632

  Fly   625 SFVSDGDHGLSFFDECAEK------VGNYD----ETPAQLHLVDWDTGQNSERTKYIFPPDSVTP 679
            |||||.|.||:|||:|.||      |...|    ::.....|::.|..|.||.|.:|.||:
  Rat   633 SFVSDKDTGLAFFDDCIEKLFPDKGVEKTDKVDLDSAEDTKLIELDDSQKSEHTVFITPPE---- 693

  Fly   680 AGSQPGGGGGGLA--YNYENF-TLQPELLQSTKKTALSKFLQLQLNASLSPGSPI-------ARR 734
               .|...|..|:  |:|..| .|..:|..|.::..| :|      :...|||.|       |:|
  Rat   694 ---PPPDDGSDLSPQYSYTYFPRLDLKLFDSPQEPKL-RF------SRHPPGSGITNSPALMAKR 748

  Fly   735 TKHEIKLSQKMASRCQQHPEAWSKYLLATCYSLYFLILPSMVLDPRHAGKEPEILRAAYDVLVRA 799
            ||.|||.:.|:|.||..:|..|:|||.:.||||:|:.||:.|   |.:..:...|:.|:||||:.
  Rat   749 TKQEIKTAHKLAKRCYTNPPQWAKYLFSHCYSLWFICLPAYV---RVSHPKVRALQQAHDVLVKM 810

  Fly   800 SRLKI-TCDEFCYRIMMQLCGIHNLPVLAVRLHYLMKRSGVQANALTYGFYNRCVLESQWPQDST 863
            .:..: ..||.|||::|||||:...||||||:.:.||.:.::.||:|||:||:.||||.|| .||
  Rat   811 RKTDVDPLDEVCYRVVMQLCGLWVHPVLAVRVLFEMKTARIKPNAITYGYYNKVVLESPWP-SST 874

  Fly   864 TISQIRWNRIKNVVLGAAQFR----KAGKQRAASKVNK----------------SLSASQDQN-- 906
            ......|.:::|||.|.||||    |.|::.....::.                |:.:|.|.|
  Rat   875 RSGIFLWTKVRNVVHGLAQFRQPLKKTGQKSQVFSISAPQNAACGSDGDTVSHGSVDSSNDANNG 939

  Fly   907 --------LSTLETVDGQSRTSLASSSGDGGGHGLLD-----FAAFDRLRNKL------------ 946
                    |.:|:::|..|.|...|..|.|....|:.     .|:.:.:..:|
  Rat   940 EHTVFVKDLISLDSIDNHSSTGGQSDQGYGSKDELVKEDADIHASEEHMPQELTATELHIEEESD 1004

  Fly   947 -------------------------GSIV-----------RQTVTGGNNETM------------G 963
                                     .|||           |.:.||.::..:            |
  Rat  1005 LSTIVPKHSQPTPEPQSPTEPPAWGSSIVKVPSGLFDTNNRTSSTGSSSNALFSTQAPVEDAVFG 1069

  Fly   964 DAVN--------------------------NTGLL-----------------------IPGELSA 979
            :|.|                          ..|:|                       :...|:.
  Rat  1070 EATNFKKSGDRGEKRQKHFPERSCSFSSESRAGMLLKKSSLDLNSSEMAIMMGADAKILTAALTC 1134

  Fly   980 PNTP------TYG--------------------------------------------GDT----- 989
            |.|.      |:.                                            |||
  Rat  1135 PKTSPLHVARTHSFENVNCHLADNRTRVSEGIWDSEHRSSPVLEMLEESQELLEPVVGDTVAETA 1199

  Fly   990 -EILAKALQQQQPRKQIMSIGGGDDDDEDEDEDEYTAGSPSTPQKQLEAGADDLEYAGGGDYEAD 1053
             |:....:|......|......|..|..::....||.|. :..::.:|.|.|.|........|..
  Rat  1200 VEMSFNNVQSNSNSNQSRDTKAGSQDTVNKRSSSYTTGK-AIEREDVETGLDPLSLLATECVEKT 1263

  Fly  1054 EEDEDEVDEHVAAQRARQRVQSPTKISPRTPVTQNDPLGALNEEESAASATPTQETQQEQQHSQS 1118
            .:.||::...|.::.....::|...:        ..|||:     .::|.....|..||
  Rat  1264 SDSEDKLFSPVISRNLADEIESYMNL--------KSPLGS-----KSSSMELHGEGNQE------ 1309

  Fly  1119 QIDSSIYSDKPILF-----RGQRSATFDESTQIGKS---MHRSETMPVASSGVTNSLANIGSSLK 1175
                   ...|.||     |.....:..:||:|.||   :.||:|:.
  Rat  1310 -------PGSPALFTHPLERRSSLPSAQDSTEIEKSPPAVSRSKTLT------------------ 1349

  Fly  1176 FTFGRY---SPARLSLKKDLKLPANI----IENISSISPSLTGKKSNELIQGS-----LSSIKSA 1228
               ||:   :|.|....:...|.|.:    ..::.|:..||:|.|.:.::.|.     .||:|.|
  Rat  1350 ---GRFKPQTPYRTYKDRSTSLSALVRSSPNSSLGSVVNSLSGLKLDNILSGPKIDVLKSSMKQA 1411

  Fly  1229 ANSLTKKFDEIKGVISANSTPTKTNNGH-HPHGLHHGHHHPHHHHHHHSQHGNAEQEEHDAAVHE 1292
            |...:|.:..:....|.:....:.|..: .|.||                      |:|    |.
  Rat  1412 ATVASKMWVAVASAYSYSDDEEEPNKDYSFPAGL----------------------EDH----HI 1450

  Fly  1293 EGKLRRVSSDLDPWGRLSESRKSSYNNLVP---------LGENSSTGALHMHAFPA--VP----- 1341
            .|:              |.|..:|.:.|||         ||.:||:|.:.....|.  ||
  Rat  1451 LGE--------------SLSPTTSISGLVPSELTQSSTSLGSSSSSGDVGKSQCPTGEVPFSRNI 1501

  Fly  1342 --------DNLYSL-TSENAADRDCDVLIQLTTCSQCHNCSVLVYDEEIMSGWTAEDSNLNTTCH 1397
                    |:..|. ||.::..::|.:.:.:::||||..|..||||||||:||||:||||||||.
  Rat  1502 KGQDFEKSDHGSSQNTSMSSIYQNCAMEVLMSSCSQCRACGALVYDEEIMAGWTADDSNLNTTCP 1566

  Fly  1398 ACNKLTVPFLSVQIERQ-------VEESEQSDPLQDG---------------------------- 1427
            .|....:|.|:|:.:..       ::.|...|.||.|
  Rat  1567 FCKSNFLPLLNVEFKDLRGSASFFLKPSTSGDSLQSGSIPSANEPLEHKPVSSSAEPDLISFMDY 1631

  Fly  1428 ----------------------------------------KEQIANGNSHKTS------------ 1440
                                                    |..::...||...
  Rat  1632 SKHSETITEEASYTVESSDEIKKTSDVQSVKMSSVPNSLSKRNVSLTRSHSVGGPLQNIDVSQRP 1696

  Fly  1441 ----------------------------LTVPYLNPLVLRKELENILTQEGDIALIKPEFVDEHP 1477
                                        ::||||:|||||||||::|..|||..:....|:::||
  Rat  1697 FHGISTVSLPNSLQEDVDHLGKRPNPPPVSVPYLSPLVLRKELESLLENEGDQVIHTSSFINQHP 1761

  Fly  1478 IIYWNLLWLMERIESKTHLPELCLPVPSDKEHID-----PLSKV----KTVHIQCLWDNLSLHTE 1533
            ||:|||:|...|::..::||.|.|    ..||.:     |||.:    |.|:||.||||::||.|
  Rat  1762 IIFWNLVWYFRRLDLPSNLPGLIL----TSEHCNEGVQLPLSSLSQDSKLVYIQLLWDNINLHQE 1822

  Fly  1534 ASGPPMYLLYRETQPTSPLIKALLTDQAQLNKNVIQQIISAIRCNDFATPLKRLANERHKLKSNG 1598
             .|.|:|:.:|.......|  :||:::.|....:::.|..:|:.||...|:..|:.:   :|.:
  Rat  1823 -PGEPLYVSWRNLNSEKKL--SLLSEEQQAASALVETIRQSIQQNDVLKPINLLSQQ---MKPD- 1880

  Fly  1599 VERSHSFYRDILFLALTAIGRSNVDLATFHREYAAVFDKLTERECNMYYRNQDLPPSASTIFCRA 1663
            .:|..|.||:||||:|.::||.|:|:..|..||...:..|:. |.....:..|.|||.|..:||.
  Rat  1881 TKRQRSLYREILFLSLVSLGRENIDIEAFDNEYGLAYRSLSS-EILEKLQKIDAPPSISVEWCRK 1944

  Fly  1664 YF-RPLL 1669
            .| .||:
  Rat  1945 CFGAPLI 1951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Crag	NP_001162710.2	uDENN	189..279	CDD:214824	45/89 (51%)
		DENN	308..492	CDD:307995	105/190 (55%)
		dDENN	551..624	CDD:129037	41/72 (57%)
		PPR repeat	808..837	CDD:276811	17/28 (61%)
Dennd4c	XP_038967015.1	uDENN	193..276	CDD:214824	45/90 (50%)
		DENN	309..492	CDD:396629	105/189 (56%)
		dDENN	559..632	CDD:129037	41/72 (57%)
		PPR repeat	820..849	CDD:276811	17/28 (61%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334947
Domainoid	1	1.000	398	1.000	Domainoid score	I721
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	995	1.000	Inparanoid score	I283
OMA	1	1.010	-	-		QHG46628
OrthoDB	1	1.010	-	-		D47872at33208
OrthoFinder	1	1.000	-	-		FOG0001463
OrthoInspector	1	1.000	-	-		otm45067
orthoMCL	1	0.900	-	-		OOG6_102394
Panther	1	1.100	-	-	LDO	PTHR12296
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X917
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910