DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Crag and Sbf1

DIOPT Version :9

Sequence 1:	NP_001162710.2	Gene:	Crag / 31800	FlyBaseID:	FBgn0025864	Length:	1671	Species:	Drosophila melanogaster
Sequence 2:	XP_038934802.1	Gene:	Sbf1 / 300147	RGDID:	1307090	Length:	1950	Species:	Rattus norvegicus

Alignment Length:	1271	Identity:	263/1271 - (20%)
Similarity:	430/1271 - (33%)	Gaps:	367/1271 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 FCLPMGASLEAWPHVNGTEKRKPISPVFSTFVLTVSD-GTYKVYGSALTFYEDYDESK-----LS 288
            ||.|.|..|        ..:|.|  |.|  ||..::| .:.:.|.:.|||:|..:.::     ..
  Rat    97 FCQPSGWQL--------CPERNP--PTF--FVAVLTDINSERHYCACLTFWEPVESTQEVMCTED 149

  Fly   289 AEQKELLGWDEEFG---AQHS---------LHMIKAICLLSHHPFGDTFDKWLKYLHRMVLYDVN 341
            |.:||    :|..|   ||.|         |...|.:.|:|.....|.|...|..::.:.:..:|
  Rat   150 ATEKE----EEAHGGGQAQLSSTAPAQPGQLFAPKTLVLVSRLDHADVFRNSLGLIYTIHVEGLN 210

  Fly   342 IPIPVERYITQLLD-EVPFPAPSIHLQLSS----------ESNDRILLTQPEDSPLPRSGAGFHI 395
            :.:  |..|..||. .||....|   ||.|          .:.||.::..|....||.|.....:
  Rat   211 VNL--ENVIGNLLTCTVPLAGGS---QLDSVEEGARTISLGAGDRQVIQTPLVDSLPVSRCSVAL 270

  Fly   396 LLQNLGTDNCLHVLLLALTEQKILIHSLRPATLTAVAEAIVSLLFPFKWQCPYIPLCPLGLAEVL 460
            |.:.||..|.|.:...||||.|:|..|.....|......:::||||.::...|:|:.|..|.|||
  Rat   271 LFRQLGITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVL 335

  Fly   461 HAPLPYLIGVDSRFFDLYEPPTDVTCIDLDTNNISLCESQRHLS--PKLLPKRAARLLRQTL-TE 522
            ..|.|::|||::.|....:...||...|||...:::.|.. |:.  |:.|..:...:|...| .|
  Rat   336 STPTPFIIGVNAAFQAETQELLDVIVADLDGGTVTVPECV-HIPPLPEPLQSQTHNVLSMVLDPE 399

  Fly   523 LENAK---PISYDSTNSL---DRDIRKRKRELVLEQRIQEAFLLFMASILRGYRDFLVPISKAPS 581
            ||.|.   |....|.:||   |:::|             ..||...|.:|:|||..|..:...|
  Rat   400 LELADLAFPPPTTSASSLKMQDKELR-------------AVFLRLFAQLLQGYRWCLHIVRIHP- 450

  Fly   582 VGATDPSALFQLKAFLRSRDKSHQKFFELMMKTQMFIRFIEERSFVSDGDHGLSF-----FDE-C 640
                :|...|...|||..|......|...:::...|..|:.||        |:.:     ||| .
  Rat   451 ----EPVIRFHKAAFLGQRGLVEDDFLMKVLEGMAFAGFVSER--------GVPYRSTDLFDELV 503

  Fly   641 AEKVGNYDETPAQLHLVDWDTGQNSERTKYIFPPDSVTPAGS----QPGGGGGGLAYNYENFTLQ 701
            |.:|..........|.|   .....|..:.::..::..||.:    |..|....|...:..|
  Rat   504 AHEVARMRADENHPHRV---LRHVQELAEQLYKNENPYPAVAMHKVQRPGEASHLRRTHRPF--- 562

  Fly   702 PELLQSTKKTALSKFLQLQLNASLSPGSPIARRTKHEIKLSQ-----KMASRCQQHPEAWSKYLL 761
            |.|.:.|.:..:.:      .|:...|:|.|.:.:....:..     .:..|| ..|...|...|
  Rat   563 PRLDEGTVQWIVDQ------AAAKMQGAPPAVKAERRTTVPSGPPMTAILERC-SGPHINSARRL 620

  Fly   762 ATCYSLYFLILPSMVLDPRHAGKEPEILRA----------AYD--VLVRASRLKITCDEFCYRIM 814
            ....:....:....:|:.:..  .|.:|||          |::  :.|:.:|..:...:|.:.:.
  Rat   621 EVVRNCISYVFEGKMLEAKKL--LPAVLRALKGRAARRCLAHELHLHVQQNRAVLDHQQFDFVVR 683

  Fly   815 MQLCGIHNLPVLAVRLHYLMKRSGVQAN--ALTYGFYNRCVLESQWPQDSTTISQIRWNRI-KNV 876
            |..|.:.:...|        ...|:.|.  .|...|..:.         |..::|..::.: ::|
  Rat   684 MMNCCLQDCTSL--------DEHGIAAALLPLVTAFCRKL---------SPGVTQFAYSCVQEHV 731

  Fly   877 VLGAAQFRKAGKQRAASKVNKSLSASQDQNLS-TLETVDGQSRTSLASSSGDGGGHGLLDFAAFD 940
            |....||.:|..........::|.......:| |.||.:.||:....|:         ||.|:..
  Rat   732 VWSTPQFWEAMFYGDVQTHIRALYLEPSDGVSPTQETGEAQSQDDERSA---------LDVASEQ 787

  Fly   941 R------LRNKLGSIVRQTVTGGNNETMGDAVNNTGLLIPGELSAPN--TPTYG-GDTEILAKAL 996
            |      .|.|...:|::..:...::.:..|...:.||:|.:.|...  ....| ||.|..:.:|
  Rat   788 RRLWPTLSREKQQELVQKEESTVFSQAIHYANRMSYLLLPLDSSKSRLLRERAGLGDLESASNSL 852

  Fly   997 QQQQPRKQIMSIGGG---DDDDEDEDEDEYT---------------------AGSPSTPQKQLEA 1037
            ...       |:.|.   ..|.|...||..|                     :|..|...|.|..
  Rat   853 VTN-------SMAGSVAESYDTESGFEDAETCDVAGAVVRFINRFVDKVCTESGVTSDHLKGLHV 910

  Fly  1038 GADDLEYAGGGDYEADEEDEDEVDEHV----AAQRARQR---VQSPTKISPR------------- 1082
            ...|:                 |..|:    |..|..:|   :|.|..:.||
  Rat   911 MVPDI-----------------VQMHIETLEAVHRESKRLPPIQKPKLLRPRLLPGEECVLDGLR 958

  Fly  1083 ------------------------------------------------TPVTQNDPLGALNEEES 1099
                                                            ..|.::.|:.||.:|:.
  Rat   959 VYLLPDGREEGVGGSGGGPALLPAEGAVFLTTYRVIFTGMPTDPLVGEQVVVRSFPVAALTKEKR 1023

  Fly  1100 AASATPTQETQQEQQHSQS--------QIDSSIYSDKPILFRGQRSATFDESTQIGKSMHRSETM 1156
            .:..||..:..|:....:|        ..|..:.||...|||              |.:|:....
  Rat  1024 ISVQTPVDQLLQDGLQLRSCTFQLLKMAFDEEVGSDSAELFR--------------KQLHKLRYP 1074

  Fly  1157 PVASSGVTNSLANIGSSLKFTFG-RYSPARLSLKKDLKLPANIIENISSISPSLTGKKSNELIQG 1220
            |           :|.::..||.| ..:|.|                    .|.:|..|.......
  Rat  1075 P-----------DIRATFAFTLGSALTPGR--------------------PPRVTKDKGPSFRTL 1108

  Fly  1221 SLSSIKSAANSLTKKFDEIKGVISANSTPTKTNNGHHPHGLHHGHHHPHHHHHHHSQHGNAEQEE 1285
            |.:.:|:|..::.:::              .|...::|.|..|....|            .|.:|
  Rat  1109 SRNLVKNAKKTIGRQY--------------VTRKKYNPPGWEHRGQPP------------PEDQE 1147

  Fly  1286 HDAAVHEEGKLRRVSSDLDPWGRLSESRKSSYNNLV 1321
            .:.:|.||.:    .|.|.|...|..|.:.:.::||
  Rat  1148 DEISVSEELE----PSTLTPSSALKPSDRMTMSSLV 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Crag	NP_001162710.2	uDENN	189..279	CDD:214824	15/49 (31%)
		DENN	308..492	CDD:307995	58/194 (30%)
		dDENN	551..624	CDD:129037	18/72 (25%)
		PPR repeat	808..837	CDD:276811	4/28 (14%)
Sbf1	XP_038934802.1	uDENN	<97..132	CDD:397495	13/46 (28%)
		DENN	178..367	CDD:214823	58/193 (30%)
		dDENN	421..489	CDD:129037	20/85 (24%)
		SBF2	600..821	CDD:403522	44/249 (18%)
		PH-like	950..1068	CDD:418428	16/131 (12%)
		PTP_DSP_cys	1207..1579	CDD:421693
		PH_Sbf1_hMTMR5	1843..1948	CDD:269941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810