Protein Alignment Crag and DENND5A

DIOPT Version :9

• Sequence 1: NP_001162710.2
• Gene: Crag / 31800
• FlyBaseID: FBgn0025864
• Length: 1671
• Species: Drosophila melanogaster
• Sequence 2: NP_056028.2
• Gene: DENND5A / 23258
• HGNCID: 19344
• Length: 1287
• Species: Homo sapiens
• Alignment Length: 1352
• Identity: 279/1352 - (20%)
• Similarity: 463/1352 - (34%)
• Gaps: 441/1352 - (32%)

  Fly   198 PKHISYKPEILLRYP------TFDHTDFPLNLCPSVPLFCLPMGASLEAWPHVNGTEKRKPISPV 256
            |...::|.::|.|||      .||.        .:|.:.|:|.|.:.:.        :..|..|.
Human    68 PLRRTFKSKVLARYPENVEWNPFDQ--------DAVGMLCMPKGLAFKT--------QADPREPQ 116

  Fly   257 FSTFVLTVSDGTYKVYGSALTFYEDYDESKLSAEQKELLGW-DEEFGAQH--------------- 305
            |..|::|..||: :.:|.||||||:....::.:..:.|... :.|:...|
Human   117 FHAFIITREDGS-RTFGFALTFYEEVTSKQICSAMQTLYHMHNAEYDVLHAPPADDRDQSSMEDG 180

  Fly   306 -------------------SLHMIKAICLLSHHPFGDTFDKWLKYLHRMVLYDVNIPIPVERYIT 351
                               :|::.|.|||::...|.......|:.||:.|......|:|:|.||.
Human   181 EDTPVTKLQRFNSYDISRDTLYVSKCICLITPMSFMKACRSVLEQLHQAVTSPQPPPLPLESYIY 245

  Fly   352 QLLDEVPFPAPSIHLQLSSESNDRILLTQPEDSPLPRSGAGFHILLQNLGTDNCLHVLLLALTEQ 416
            .:|.|||.|.|...|:.|..... |:..:|..:.||........:.:.||.:|...:...||.|.
Human   246 NVLYEVPLPPPGRSLKFSGVYGP-IICQRPSTNELPLFDFPVKEVFELLGVENVFQLFTCALLEF 309

  Fly   417 KILIHSLRPATLTAVAEAIVSLLFPFKWQCPYIPLCPLGLAEVLHAPLPYLIGVDSRFFD----L 477
            :||::|.....|..|||.|.:|:|||:||..|:|:.|..|...|.||:|||:|:.|...|    |
Human   310 QILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILPASLLHFLDAPVPYLMGLHSNGLDDRSKL 374

  Fly   478 YEPPTDVTC-IDLDTNNISLCESQRHLSPKL--------------LP--------KRAARLLRQT 519
            ..|.....| :|:|.:.|.|.|.......||              :|        :.|::|.|..
Human   375 ELPQEANLCFVDIDNHFIELPEDLPQFPNKLEFVQEVSEILMAFGIPPEGNLHCSESASKLKRLR 439

  Fly   520 LTELENAK--------PI-SY------------------------------DSTNSLDRDIRKRK 545
            .:||.:.|        |: ||                              |.:::.|..::..:
Human   440 ASELVSDKRNGNIAGSPLHSYELLKENETIARLQALVKRTGVSLEKLEVREDPSSNKDLKVQCDE 504

  Fly   546 RELVLEQ---RIQEAFLLFMASILRGYRDFLVPISKAPSVGATDPSAL--FQLKAFLRSRDKSHQ 605
            .||.:.|   :|:|.|......:...|..|::..|:......|:...:  |...:||..:.:.:.
Human   505 EELRIYQLNIQIREVFANRFTQMFADYEVFVIQPSQDKESWFTNREQMQNFDKASFLSDQPEPYL 569

  Fly   606 KFFELMMKTQMFIRFIEERSFVSDGDH-------------------------GLSFFDEC----- 640
            .|....::||||..||:.:....|.|.                         ..|.:.:|
Human   570 PFLSRFLETQMFASFIDNKIMCHDDDDKDPVLRVFDSRVDKIRLLNVRTPTLRTSMYQKCTTVDE 634

  Fly   641 AEK-----VGNYDETPAQLHLVDWDTGQNSERTKYIFPPDSVTPAGSQPGGGGGGLAYNYENFTL 700
            |||     :...|.|....||:|...||.    ||            :||
Human   635 AEKAIELRLAKIDHTAIHPHLLDMKIGQG----KY------------EPG--------------- 668

  Fly   701 QPELLQSTKKTALSKFLQLQLNASLSPGSPIARRTKHEIKLSQKMASRCQQHPE-------AWSK 758
                          .|.:||.:. ||.|....:.||.......:...|.:||.|       ...|
Human   669 --------------FFPKLQSDV-LSTGPASNKWTKRNAPAQWRRKDRQKQHTEHLRLDNDQREK 718

  Fly   759 YLLATCYSLYFLILPSMVLDPRHAGKEPEILRAAYDVLVRASRLKITCDEFCYRIMMQLCGIHNL 823
            |:...      ..:.|.:..|:.:...|.::.......|..  |...|.....|::::..|..
Human   719 YIQEA------RTMGSTIRQPKLSNLSPSVIAQTNWKFVEG--LLKECRNKTKRMLVEKMGRE-- 773

  Fly   824 PVLAVRL-HYLMKRSGVQANALTYGFYNRCVLESQW------PQDSTTISQIRW--------NRI 873
               ||.| |..:..:||:.|.|.....:  :||..|      .|..:.:    |        ||.
Human   774 ---AVELGHGEVNITGVEENTLIASLCD--LLERIWSHGLQVKQGKSAL----WSHLLHYQDNRQ 829

  Fly   874 KNVVLGA---------AQFRKAGKQRAASKVNKSLSAS--QD----QNLSTLETVDGQSRTSLAS 923
            :.:..|:         ::.||:.    ||.:...|..|  ||    ||:..::|..|::|..:..
Human   830 RKLTSGSLSTSGILLDSERRKSD----ASSLMPPLRISLIQDMRHIQNIGEIKTDVGKARAWVRL 890

  Fly   924 S----------------------------------SGDGGGHGLLDFAAFDR--LRNKLGS---- 948
            |                                  ..:...:.||.|.|.|.  ..|...:
Human   891 SMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQFLYHLLSFNAVDYFCFTNVFTTILIP 955

  Fly   949 ----IVRQTVTGGNNETMGDAVNNTGLLIPGELSAPNTPTYGGDTEILAKALQQQQPRK------ 1003
                ||.....||:..|.     |..:.|.|||         |:|:|:      |.||.
Human   956 YHILIVPSKKLGGSMFTA-----NPWICISGEL---------GETQIM------QIPRNVLEMTF 1000

  Fly  1004 ------QIMSIGGGDDD---------DEDEDEDEYTAGSPSTP-QKQLEAGADD--LEYAGGGDY 1050
                  ::.::..|.|:         :.....:|.|..:...| .:.|..|.||  ||....|:.
Human  1001 ECQNLGKLTTVQIGHDNSGLYAKWLVEYVMVRNEITGHTYKFPCGRWLGKGMDDGSLERILVGEL 1065

  Fly  1051 EADEEDEDEVDEHVAAQRARQRVQSPTKISPRTPVTQND--PLGALNEEESAASAT--------- 1104
            ..   .:.||||...  |.....|||:.|.....::.|:  .|.....:||...|.
Human  1066 LT---SQPEVDERPC--RTPPLQQSPSVIRRLVTISPNNKPKLNTGQIQESIGEAVNGIVKHFHK 1125

  Fly  1105 PTQE-----------------TQQEQQHSQSQIDSSIYSDKPILFRG-------QRSATFDESTQ 1145
            |.:|                 .:|..||.         ...|.||:.       :::.|:.|
Human  1126 PEKERGSLTLLLCGECGLVSALEQAFQHG---------FKSPRLFKNVFIWDFLEKAQTYYE--- 1178

  Fly  1146 IGKSMHRSETMPVAS------------SGVTNSLANIGSSLKFTFGRYSPAR-------LSLKKD 1191
               ::.::|.:|..:            :.:.|:..|||...||.......||       ::|..|
Human  1179 ---TLEKNEVVPEENWHTRARNFCRFVTAINNTPRNIGKDGKFQMLVCLGARDHLLHHWIALLAD 1240

  Fly  1192 LKLPANIIENISSISPSLTGKKSNELIQGSLSSIKSAAN-SLTKKFDEIKGV 1242
            ..:.|::.|:::.|       |.:.|:...:..:::... ::|.:...:||:
Human  1241 CPITAHMYEDVALI-------KDHTLVNSLIRVLQTLQEFNITLETSLVKGI 1285

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Crag	NP_001162710.2	uDENN	189..279	CDD:214824	23/86 (27%)
		DENN	308..492	CDD:307995	64/188 (34%)
		dDENN	551..624	CDD:129037	18/77 (23%)
		PPR repeat	808..837	CDD:276811	6/29 (21%)
DENND5A	NP_056028.2	uDENN	12..138	CDD:214824	23/86 (27%)
		DENN	202..390	CDD:307995	64/188 (34%)
		dDENN	513..588	CDD:129037	17/74 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	681..709		7/27 (26%)
		RUN	795..942	CDD:322053	26/156 (17%)
		PLAT_RAB6IP1	954..1062	CDD:238855	27/127 (21%)
		RUN	1143..1277	CDD:322053	25/155 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3728
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.930