DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Crag and DENND3

DIOPT Version :9

Sequence 1:	NP_001162710.2	Gene:	Crag / 31800	FlyBaseID:	FBgn0025864	Length:	1671	Species:	Drosophila melanogaster
Sequence 2:	NP_001349727.1	Gene:	DENND3 / 22898	HGNCID:	29134	Length:	1296	Species:	Homo sapiens

Alignment Length:	849	Identity:	178/849 - (20%)
Similarity:	300/849 - (35%)	Gaps:	236/849 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 SVPLFCLPMGASLEAWPHVNGTEKRKPISPVFSTFVLTVSDGTYKVYGSALTFYED-YDESKL-- 287
            ::|..|.|.|..:       .||   |........|||...|. :.||....:|.. :||...
Human   121 TLPQLCFPGGVCV-------ATE---PKEDCVHFLVLTDVCGN-RTYGVVAQYYRPLHDEYCFYN 174

  Fly   288 SAEQKELLGWDEEFGAQHSLHMIKAICLLSHHPFGDTFDKWLKYLHRMV--LYDVNIPIPVERYI 350
            ....:|..|....|          |:|::|..|:.::....|..|..::  ..|..:...::.:.
Human   175 GKTHRECPGCFVPF----------AVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFA 229

  Fly   351 TQLLDEVPFPAPS-IHLQLSSESNDRILLTQPEDSPLPRSGAGFHILLQNLGTDNCLHVLLLALT 414
            .: |..:|.|.|. :||..:.:|. :|:|....|...|......|:.|.....:..|.:|...||
Human   230 AK-LSLIPSPPPGPLHLVFNMKSL-QIVLPARADPESPILDLDLHLPLLCFRPEKVLQILTCILT 292

  Fly   415 EQKILIHSLRPATLTAVAEAIVSLLFPFKWQCPYIPLCPLGLAEVLHAPLPYLIGVDSRFFDLYE 479
            ||:|:..|...|.||.|.|..::.|:|.:||.|::|:....:.:.:.||..:|:|.....|:...
Human   293 EQRIVFFSSDWALLTLVTECFMAYLYPLQWQHPFVPILSDQMLDFVMAPTSFLMGCHLDHFEEVS 357

  Fly   480 PPTD-VTCIDLDTNNISLCES-QRHLSPKLLPKRAARLLRQTLT------ELENAKPISYDSTNS 536
            ...| :..|::|..:|:..:| ..::....:|..||:...|.:.      ||..|..:|  ||:.
Human   358 KEADGLVLINIDHGSITYSKSTDDNVDIPDVPLLAAQTFIQRVQSLQLHHELHAAHLLS--STDL 420

  Fly   537 LDRDIRKRKRELVLEQRIQEAFLLFMASILRGYRDFLVPISKAPSVGATDPSALFQLKAFLRSRD 601
            .:....:|..:..|..:||:..|..:.||.|..::.|           .....:|..:.||::|.
Human   421 KEGRAHRRSWQQKLNCQIQQTTLQLLVSIFRDVKNHL-----------NYEHRVFNSEEFLKTRA 474

  Fly   602 KSHQKFFELMMKTQMFIRFIEERSFVSDGDHGLSFFDECAEKVGNYDETPAQLHLVDWDTGQNSE 666
            ....:|::.::.|.||..|::.|                   :....:..||:   |.||....:
Human   475 PGDHQFYKQVLDTYMFHSFLKAR-------------------LNRRMDAFAQM---DLDTQSEED 517

  Fly   667 RTK-YIFPPDSVT------------------PAGSQPGGGGGGLAYNYENFTLQPELLQSTKK-- 710
            |.. .:..|...|                  ...|.|         |.::..: |||......
Human   518 RINGMLLSPRRPTVEKRASRKSSHLHVTHRRMVVSMP---------NLQDIAM-PELAPRNSSLR 572

  Fly   711 ---TALSKFLQLQLNASLSPGSPIARRTKHEIKLSQ---KMASRCQQ--HPEAWSKYLLATCY-- 765
               ||..:.....||  ::|.||      :..|:.:   .:.|:|.|  |....|....|.|:
Human   573 LTDTAGCRGSSAVLN--VTPKSP------YTFKIPEIHFPLESKCVQAYHAHFVSMLSEAMCFLA 629

  Fly   766 --------------SLYFLI---LPSMVLD--------------------------PRHAGKE-- 785
                          .|.:|:   |.:.:||                          |...|.|
Human   630 PDNSLLLARYLYLRGLVYLMQGQLLNALLDFQNLYKTDIRIFPTDLVKRTVESMSAPEWEGAEQA 694

  Fly   786 PEILRAAYDVLVR---ASRLKITCDEFCYRIMMQLCGIHNLPVLAVRLHYLMKR---SGVQAN-- 842
            ||::|...::|.:   ||:|.....:|            .||...::|...|||   ||:..:
Human   695 PELMRLISEILDKPHEASKLDDHVKKF------------KLPKKHMQLGDFMKRVQESGIVKDAS 747

  Fly   843 -------ALTYG------------FYNRCVLESQWPQDSTTISQIR--WNRIKNVVLGAAQFRKA 886
                   |||.|            ||| |     |.:......::.  |..::::
Human   748 IIHRLFEALTVGQEKQIDPETFKDFYN-C-----WKETEAEAQEVSLPWLVMEHL---------- 796

  Fly   887 GKQRAASKVNKSLSASQDQNLSTLETVDGQSRTSLASSSGDGGGHGLLDFAAFDRLRNKLGSIVR 951
            .|.....|    ||:|...||...:....|.|..|.:.    |..|.|:.:.|..:..     ||
Human   797 DKNECVCK----LSSSVKTNLGVGKIAMTQKRLFLLTE----GRPGYLEISTFRNIEE-----VR 848

  Fly   952 QTVT 955
            :|.|
Human   849 RTTT 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Crag	NP_001162710.2	uDENN	189..279	CDD:214824	13/52 (25%)
		DENN	308..492	CDD:307995	47/187 (25%)
		dDENN	551..624	CDD:129037	16/72 (22%)
		PPR repeat	808..837	CDD:276811	7/31 (23%)
DENND3	NP_001349727.1	uDENN	<122..158	CDD:322520	12/46 (26%)
		DENN	185..371	CDD:307995	48/197 (24%)
		dDENN	435..497	CDD:129037	16/72 (22%)
		WD40	1019..>1120	CDD:330360
		WD40 repeat	1028..1063	CDD:293791
		WD40 repeat	1067..1108	CDD:293791
		WD40 repeat	1114..1152	CDD:293791
		WD40 repeat	1160..1196	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141276
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12296
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840