DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Crag and DENND5B

DIOPT Version :9

Sequence 1:	NP_001162710.2	Gene:	Crag / 31800	FlyBaseID:	FBgn0025864	Length:	1671	Species:	Drosophila melanogaster
Sequence 2:	XP_005253383.1	Gene:	DENND5B / 160518	HGNCID:	28338	Length:	1333	Species:	Homo sapiens

Alignment Length:	966	Identity:	201/966 - (20%)
Similarity:	330/966 - (34%)	Gaps:	356/966 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 PKHISYKPEILLRYP------TFDHTDFPLNLCPSVPLFCLPMGASLEAWPHVNGTEKRKPISPV 256
            |...::|.::|..||      .||.        .:|.:.|:|.|.|..     ..|:.:   .|.
Human    72 PLRRTFKSKVLAHYPQNIEWNPFDQ--------DAVNMLCMPKGLSFR-----TQTDNK---DPQ 120

  Fly   257 FSTFVLTVSDGTYKVYGSALTFYEDYDESKLSAEQKELLGWDEEFGAQH---------------- 305
            |.:|::|..||: :.||..|||||:....::....:.|.   :...|:|
Human   121 FHSFIITREDGS-RTYGFVLTFYEEVTSKQICTAMQTLY---QMHNAEHYSSVYASSSCSMDSLA 181

  Fly   306 -------------------------SLHMIKAICLLSHHPFGDTFDKWLKYLHRMVLYDVNIPIP 345
                                     :|::.|:|||::..||.....|:|..|::.|......|:|
Human   182 SSLDEGDTTSLLKLQRYNSYDISRDTLYVSKSICLITPLPFMQACKKFLIQLYKAVTSQQPPPLP 246

  Fly   346 VERYITQLLDEVPFPAPSIHLQLSSESNDRILLTQPEDSPLPRSGAGFHILLQNLGTDNCLHVLL 410
            :|.||..:|.|||.|.|...|:... ..:.::..:|..|.||.|........:.||.:|.:.|..
Human   247 LESYIHNILYEVPLPPPGRSLKFYG-VYEPVICQRPGPSELPLSDYPLREAFELLGLENLVQVFT 310

  Fly   411 LALTEQKILIHSLRPATLTAVAEAIVSLLFPFKWQCPYIPLCPLGLAEVLHAPLPYLIG------ 469
            ..|.|.:||::|.....|..|||.|.:|||||:||..|:|:.|..|...|.||:|||:|
Human   311 CVLLEMQILLYSQDYQRLMTVAEGITTLLFPFQWQHVYVPILPASLLHFLDAPVPYLMGLQSKEG 375

  Fly   470 ------------------VDSRFFDLYE-------------------------PPTDVTCID--- 488
                              :|:.|.:|.|                         |...:.|.:
Human   376 TDRSKLELPQEANLCFVDIDNHFIELPEEFPQFPNKVDFIQELSEVLVQFGIPPEGSLHCSESTS 440

  Fly   489 ------------------LDTNNISLCESQRHLSPKLLP--KRAARLLRQTLTELENAKPISYDS 533
                              :.|||||:.|        ||.  :..|||  |.|.:.........|.
Human   441 KLKNMVLKDLVNDKKNGNVCTNNISMYE--------LLKGNETIARL--QALAKRTGVAVEKMDL 495

  Fly   534 TNSL---DRDIR-----KRKRELVLEQRIQEAFLLFMASILRGYRDFLVPISKAPSVGATDPSAL 590
            :.||   |:|::     ...|:..|..:::|.|......:...|..|::..::......|:...:
Human   496 SASLGEKDKDLKLHCEEAELRDYQLNVQLREVFANRFTQMFADYEAFVIQTAQDMESWLTNREQM 560

  Fly   591 --FQLKAFLRSRDKSHQKFFELMMKTQMFIRFIEER--SFVSDGDHGLSFFDECAEKVGNY---- 647
              |...:||..:.:.:..|....::||||..||:.:  |...:.|..|..||...:|:..|
Human   561 QNFDKASFLSDQPEPYLPFLSRFIETQMFATFIDNKIMSQWEEKDPLLRVFDTRIDKIRLYNVRA 625

  Fly   648 ----------------------------DETPAQLHLVDWDTGQNSERTKY---IFPPDSVTPAG 681
                                        |.|....||:|...||.    ||   .||
Human   626 PTLRTSIYQKCSTLKEAAQSIEQRLMKMDHTAIHPHLLDMKIGQG----KYEQGFFP-------- 678

  Fly   682 SQPGGGGGGLAYNYENFTLQPELLQSTKKTALSKFLQLQLNASLSPGSPIARRTKHEIKLSQKMA 746
                             .||.::| :|..|:.::::.....|                   |:..
Human   679 -----------------KLQSDVL-ATGPTSNNRWVSRSATA-------------------QRRK 706

  Fly   747 SRCQQHPEAWSKYLLATCYSLYFLILPSMVLDPRHAGKEPEILRAAYDVLVRASRL--------- 802
            .|.:||.|                          |.|.:.::...:.::||..:.:
Human   707 ERLRQHSE--------------------------HVGLDNDLREPSGELLVCQNSMAFWEWDQGP 745

  Fly   803 -------KITCDEFCYRIMMQLCGI-HNL---------PVLAVRLH-----------------YL 833
                   |.:..|.|.:.|.:...: .||         |.:..:.:                 .|
Human   746 PPPARLPKKSFSECCLKYMQEARSLGKNLRQPKLSDLSPAVIAQTNCKFVEGLLKECRMKTKRML 810

  Fly   834 MKRSGVQANALTYGFYNRCVLESQWPQDSTTISQI------RWNRIKNVVLGAA-------QFR- 884
            :::.|.:|..|.:|..|...||     ::|.|:.:      .|:....|..|.:       ||:
Human   811 VEKMGHEAVELGHGEANITGLE-----ENTLIASLCDLLERIWSHGLQVKQGKSALWSHLIQFQD 870

  Fly   885 KAGKQR--AASKV------NKS----------LSASQD----QNLSTLETVDGQSR 918
            :..||.  |.|.|      .||          :|..||    ||:|.::|..|::|
Human   871 REEKQEHLAESPVALGPERRKSDSGVMLPTLRVSLIQDMRHIQNMSEIKTDVGRAR 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Crag	NP_001162710.2	uDENN	189..279	CDD:214824	23/86 (27%)
		DENN	308..492	CDD:307995	65/253 (26%)
		dDENN	551..624	CDD:129037	15/74 (20%)
		PPR repeat	808..837	CDD:276811	7/55 (13%)
DENND5B	XP_005253383.1	uDENN	19..142	CDD:214824	23/86 (27%)
		DENN	209..397	CDD:280329	60/188 (32%)
		dDENN	521..596	CDD:129037	15/74 (20%)
		RUN	839..983	CDD:280855	21/88 (24%)
		PLAT_RAB6IP1	995..1103	CDD:238855
		RUN	1186..1323	CDD:295434
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2127
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3728
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.930