Protein Alignment CG32371 and MAPRE1

DIOPT Version :10

• Sequence 1: NP_729295.1
• Gene: CG32371 / 317999
• FlyBaseID: FBgn0052371
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: NP_036457.1
• Gene: MAPRE1 / 22919
• HGNCID: 6890
• Length: 268
• Species: Homo sapiens
• Alignment Length: 293
• Identity: 117/293 - (39%)
• Similarity: 165/293 - (56%)
• Gaps: 56/293 - (19%)

  Fly    10 VNVRYTNKLSSNSSRAEMLSWVNNTLKSQFFKVEELCTGAAYCQLMDILFARSIPMQRVKFRTNV 74
            |||..|:..|.|.||.:||:|:|.:|:....|:|:||:||||||.||:||..||.:::|||:..:
Human     3 VNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKL 67

  Fly    75 EYEYIQNFKLLQGCFNKFVVDKIIPIDRLVKGRYQDNFEFLQWFRKFFDANYESREYDPVIARNG 139
            |:|||||||:||..|.:..||||||:|:||||::||||||:|||:|||||||:.::||||.||.|
Human    68 EHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQG 132

  Fly   140 AMLGLGSPPMEAKLRKSVNKSNPQTKPTEESSA------QTDRATTEPK---NQVYKSNSENKTI 195
            ....: :|.:.|   .::||..   ||...|||      .|.|....||   ..|.|:.......
Human   133 QETAV-APSLVA---PALNKPK---KPLTSSSAAPQRPISTQRTAAAPKAGPGVVRKNPGVGNGD 190

  Fly   196 EEASAQTDLAITEPENQVHESQTKTTEKASAQTEKATTEPDSEGSIEELRNYCKYVSRMKQERNF 260
            :||:        |...||:             ..|.|.|.                  :::||:|
Human   191 DEAA--------ELMQQVN-------------VLKLTVED------------------LEKERDF 216

  Fly   261 YLSKLRAIDHICQKYNSGRDRVILEKITKIIYS 293
            |..|||.|:.|||: |.|.:..:|::|..|:|:
Human   217 YFGKLRNIELICQE-NEGENDPVLQRIVDILYA 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32371	NP_729295.1	BIM1	23..>269	CDD:227542	101/254 (40%)
		EB1	254..293	CDD:460870	16/38 (42%)
MAPRE1	NP_036457.1	BIM1	16..257	CDD:227542	111/280 (40%)
		Interaction with MTUS2/TIP150. /evidence=ECO:0000269|PubMed:19543227	124..268		47/172 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..187		13/43 (30%)
		Interaction with CDK5RAP2. /evidence=ECO:0000269|PubMed:19553473	185..268		25/104 (24%)
		Interaction with APC. /evidence=ECO:0000269|PubMed:17293347	206..211		2/22 (9%)
		DCTN1-binding. /evidence=ECO:0000269|PubMed:14514668	208..268		18/60 (30%)
		APC-binding. /evidence=ECO:0000269|PubMed:14514668	220..242		10/22 (45%)
		Interaction with SKA1. /evidence=ECO:0000269|PubMed:36592928, ECO:0000305|PubMed:27225956	232..255		5/17 (29%)