DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32371 and MAPRE1

DIOPT Version :9

Sequence 1:	NP_729295.1	Gene:	CG32371 / 317999	FlyBaseID:	FBgn0052371	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_036457.1	Gene:	MAPRE1 / 22919	HGNCID:	6890	Length:	268	Species:	Homo sapiens

Alignment Length:	293	Identity:	117/293 - (39%)
Similarity:	165/293 - (56%)	Gaps:	56/293 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VNVRYTNKLSSNSSRAEMLSWVNNTLKSQFFKVEELCTGAAYCQLMDILFARSIPMQRVKFRTNV 74
            |||..|:..|.|.||.:||:|:|.:|:....|:|:||:||||||.||:||..||.:::|||:..:
Human     3 VNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKL 67

  Fly    75 EYEYIQNFKLLQGCFNKFVVDKIIPIDRLVKGRYQDNFEFLQWFRKFFDANYESREYDPVIARNG 139
            |:|||||||:||..|.:..||||||:|:||||::||||||:|||:|||||||:.::||||.||.|
Human    68 EHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQG 132

  Fly   140 AMLGLGSPPMEAKLRKSVNKSNPQTKPTEESSA------QTDRATTEPK---NQVYKSNSENKTI 195
            ....: :|.:.|   .::||..   ||...|||      .|.|....||   ..|.|:.......
Human   133 QETAV-APSLVA---PALNKPK---KPLTSSSAAPQRPISTQRTAAAPKAGPGVVRKNPGVGNGD 190

  Fly   196 EEASAQTDLAITEPENQVHESQTKTTEKASAQTEKATTEPDSEGSIEELRNYCKYVSRMKQERNF 260
            :||:        |...||:             ..|.|.|.                  :::||:|
Human   191 DEAA--------ELMQQVN-------------VLKLTVED------------------LEKERDF 216

  Fly   261 YLSKLRAIDHICQKYNSGRDRVILEKITKIIYS 293
            |..|||.|:.|||: |.|.:..:|::|..|:|:
Human   217 YFGKLRNIELICQE-NEGENDPVLQRIVDILYA 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32371	NP_729295.1	CH	22..121	CDD:278723	57/98 (58%)
		BIM1	23..>269	CDD:227542	101/254 (40%)
		EB1	255..293	CDD:281288	16/37 (43%)
MAPRE1	NP_036457.1	BIM1	16..257	CDD:227542	111/280 (40%)
		Interaction with MTUS2/TIP150. /evidence=ECO:0000269\|PubMed:19543227	124..268		47/172 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	146..187		13/43 (30%)
		Interaction with CDK5RAP2. /evidence=ECO:0000269\|PubMed:19553473	185..268		25/104 (24%)
		DCTN1-binding	208..268		18/60 (30%)
		APC-binding	220..242		10/22 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158812
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5217
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1295
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1237523at2759
OrthoFinder	1	1.000	-	-		FOG0000490
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100898
Panther	1	1.100	-	-	O	PTHR10623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X303
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.660