DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG32371 and Mapre2

DIOPT Version :9

Sequence 1:	NP_729295.1	Gene:	CG32371 / 317999	FlyBaseID:	FBgn0052371	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_694698.3	Gene:	Mapre2 / 212307	MGIID:	106271	Length:	326	Species:	Mus musculus

Alignment Length:	289	Identity:	98/289 - (33%)
Similarity:	158/289 - (54%)	Gaps:	40/289 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VNVRYTNKLSSNSSRAEMLSWVNNTLKSQFFKVEELCTGAAYCQLMDILFARSIPMQRVKFRTNV 74
            |||..|:......||.::::|||:.:...:.|||:||:||||||.||:||...|.:::|||:..:
Mouse    45 VNVYSTSITQETMSRHDIIAWVNDIVSLNYTKVEQLCSGAAYCQFMDMLFPGCISLKKVKFQAKL 109

  Fly    75 EYEYIQNFKLLQGCFNKFVVDKIIPIDRLVKGRYQDNFEFLQWFRKFFDANYESREYDPVIARNG 139
            |:|||.||||||..|.:..|||:||:::|||||:|||.:|:|||:||:||||:.:|||||.||.|
Mouse   110 EHEYIHNFKLLQASFKRMNVDKVIPVEKLVKGRFQDNLDFIQWFKKFYDANYDGKEYDPVEARQG 174

  Fly   140 AMLGLGSPPMEA-----KLRKSVNKSNPQTKPTEESSAQTDRATTEPKNQVYKSNSENKTIEEAS 199
            ..   ..||.:.     .|.|..:.:|..|....:||..:...:|..:....|..|.:.:...:.
Mouse   175 QD---AIPPPDPGEQIFNLPKKSHHANSPTAGAAKSSPASKPGSTPSRPSSAKRASSSGSASRSD 236

  Fly   200 AQTDLAITEPENQVHESQTKTTEKASAQTEKATTEPDSEGSIEELRNYCKYVSRMKQERNFYLSK 264
            ...:..:.:...|||..:...                 ||              :::||:||..|
Mouse   237 KDLETQVIQLNEQVHSLKLAL-----------------EG--------------VEKERDFYFGK 270

  Fly   265 LRAIDHICQKYNSGRDRVILEKITKIIYS 293
            ||.|:.:||::....|.:: :::.:::|:
Mouse   271 LREIELLCQEHGQENDDLV-QRLMEVLYA 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG32371	NP_729295.1	CH	22..121	CDD:278723	52/98 (53%)
		BIM1	23..>269	CDD:227542	89/250 (36%)
		EB1	255..293	CDD:281288	11/37 (30%)
Mapre2	NP_694698.3	EB1	58..312	CDD:331377	94/276 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..239		14/71 (20%)
		DCTN1-binding. /evidence=ECO:0000250	186..326		26/145 (18%)
		APC-binding. /evidence=ECO:0000250	258..301		14/56 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..326		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849191
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5217
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1237523at2759
OrthoFinder	1	1.000	-	-		FOG0000490
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10623
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X303
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.810