Protein Alignment CG32371 and Mapre1

DIOPT Version :10

• Sequence 1: NP_729295.1
• Gene: CG32371 / 317999
• FlyBaseID: FBgn0052371
• Length: 294
• Species: Drosophila melanogaster
• Sequence 2: NP_612518.2
• Gene: Mapre1 / 114764
• RGDID: 621781
• Length: 268
• Species: Rattus norvegicus
• Alignment Length: 293
• Identity: 118/293 - (40%)
• Similarity: 164/293 - (55%)
• Gaps: 56/293 - (19%)

  Fly    10 VNVRYTNKLSSNSSRAEMLSWVNNTLKSQFFKVEELCTGAAYCQLMDILFARSIPMQRVKFRTNV 74
            |||..|:..|.|.||.:||:|:|.:|:....|:|:||:||||||.||:||..||.:::|||:..:
  Rat     3 VNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKL 67

  Fly    75 EYEYIQNFKLLQGCFNKFVVDKIIPIDRLVKGRYQDNFEFLQWFRKFFDANYESREYDPVIARNG 139
            |:|||||||:||..|.:..||||||:|:||||::||||||:|||:|||||||:.:|||||.||.|
  Rat    68 EHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKEYDPVAARQG 132

  Fly   140 AMLGLGSPPMEAKLRKSVNKSNPQTKPTEESSA------QTDRATTEPK---NQVYKSNSENKTI 195
            ....: :|.:.|..     .|.|: ||....||      .|.|.|..||   ..|.|:.......
  Rat   133 QETAV-APSLVAPA-----LSKPK-KPLGSGSAAPQRPIATQRTTAAPKAGPGMVRKNPGMGNGD 190

  Fly   196 EEASAQTDLAITEPENQVHESQTKTTEKASAQTEKATTEPDSEGSIEELRNYCKYVSRMKQERNF 260
            :||:        |...||             :..|.|.|.                  :::||:|
  Rat   191 DEAA--------ELMQQV-------------KVLKLTVED------------------LEKERDF 216

  Fly   261 YLSKLRAIDHICQKYNSGRDRVILEKITKIIYS 293
            |..|||.|:.|||: |.|.:..:|::|..|:|:
  Rat   217 YFGKLRNIELICQE-NEGENDPVLQRIVDILYA 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG32371	NP_729295.1	BIM1	23..>269	CDD:227542	102/254 (40%)
		EB1	254..293	CDD:460870	16/38 (42%)
Mapre1	NP_612518.2	BIM1	16..257	CDD:227542	112/280 (40%)
		Interaction with MTUS2/TIP150. /evidence=ECO:0000250|UniProtKB:Q15691	124..268		47/172 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	146..191		13/45 (29%)
		Interaction with APC. /evidence=ECO:0000250|UniProtKB:Q15691	206..211		2/22 (9%)
		DCTN1-binding. /evidence=ECO:0000250|UniProtKB:Q15691	208..268		18/60 (30%)
		APC-binding. /evidence=ECO:0000250|UniProtKB:Q15691	220..242		10/22 (45%)
		Interaction with SKA1. /evidence=ECO:0000250|UniProtKB:Q15691	232..255		5/17 (29%)