DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment tut and SYNCRIP

DIOPT Version :9

Sequence 1:	NP_729346.1	Gene:	tut / 317996	FlyBaseID:	FBgn0052364	Length:	230	Species:	Drosophila melanogaster
Sequence 2:	NP_006363.4	Gene:	SYNCRIP / 10492	HGNCID:	16918	Length:	623	Species:	Homo sapiens

Alignment Length:	169	Identity:	39/169 - (23%)
Similarity:	83/169 - (49%)	Gaps:	23/169 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 ELFLSCIPRNHSCSPRWIVEVASELGEVYIMRYKID-FSGNSRGYAYLQYINVDLKESAMQYLPM 101
            |:|:..|||:  .....:|.:..:.|.::.:|..:| .:|.:||||::.:..   ||:|.:.:.:
Human   163 EIFVGKIPRD--LFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCT---KEAAQEAVKL 222

  Fly   102 -------RFRQLCMCLRVEPSTNNRELVLKNVESSLRPWQVYQEMLKI-HPFTIVRVY----EYQ 154
                   ..:.:.:|:.|   .||| |.:.::..|....|:.:|..|: ...|.|.:|    :.:
Human   223 YNNHEIRSGKHIGVCISV---ANNR-LFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKK 283

  Fly   155 LDQFFYIFEYRNNDSAASAHQRVRN-SIRKFGEHAHISW 192
            .::.|...||.::.:||.|.:|:.: .::.:|....:.|
Human   284 KNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEW 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tut	NP_729346.1	RRM1_hnRNPR_like	36..115	CDD:240695	19/84 (23%)
tut	NP_729346.1	DUF3388	<127..169	CDD:288701	10/46 (22%)
SYNCRIP	NP_006363.4	NURR_hnRNPQ	23..107	CDD:410954
		hnRNP-R-Q	103..615	CDD:273732	39/169 (23%)
		Interaction with APOBEC1	400..561
		8 X 3 AA repeats of R-G-G	448..559
		3 X 4 AA repeats of Y-Y-G-Y	460..488
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..623
		Interaction with SMN. /evidence=ECO:0000269\|PubMed:11574476	518..549
		Bipartite nuclear localization signal. /evidence=ECO:0000255	564..578
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0117
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810