DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12081 and KEL3

DIOPT Version :9

Sequence 1:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_015060.1	Gene:	KEL3 / 855865	SGDID:	S000006184	Length:	651	Species:	Saccharomyces cerevisiae

Alignment Length:	173	Identity:	45/173 - (26%)
Similarity:	78/173 - (45%)	Gaps:	19/173 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 PFQRYGHTVVAYKDRIYIWGGRND-----ENLCNTLYCFDPKTAQWSRPQVTGCLPGARDGHSAC 134
            |..|.||.::|:|:...::||..|     .:..|.|:|||..|.:|::.: |...|.||.||...
Yeast   194 PSARSGHRIIAWKNYFILFGGFRDLGNGQTSYLNDLWCFDISTYKWTKLE-TNSKPDARSGHCFI 257

  Fly   135 VIGNSMYIFGGFVDEI---------NEFSSDVHSLNL--DTMEWRY--VQTFGVPPSYRDFHASV 186
            ...||..:.||:...|         .:..:|...|||  |..:|::  ::.|...||.|..::..
Yeast   258 PTDNSAILMGGYCKIIAKNNKNLMKGKILNDAWKLNLTPDPKKWQWEKLKNFKNQPSPRVGYSFN 322

  Fly   187 AYEQERMYIFGGRGDKHSPYHSQEETYCHEIVYLDMKTKVWHR 229
            .::|.:...|||..|......|.|..:.:::....::...|.:
Yeast   323 LWKQNKSVAFGGVYDLQETEESLESVFYNDLYMFHLELNKWSK 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965
		Kelch_6	13..60	CDD:290672
		KELCH repeat	78..125	CDD:276965	16/51 (31%)
		Kelch_1	78..117	CDD:279660	15/43 (35%)
		KELCH repeat	128..170	CDD:276965	14/54 (26%)
		Kelch_3	137..188	CDD:290151	15/63 (24%)
		KELCH repeat	180..236	CDD:276965	9/50 (18%)
		Kelch_3	192..248	CDD:290151	7/38 (18%)
		Kelch_5	237..276	CDD:290565
KEL3	NP_015060.1	Kelch_3	92..146	CDD:404319
		PLN02153	94..>316	CDD:177814	36/122 (30%)
		KELCH repeat	138..194	CDD:276965	45/173 (26%)
		KELCH repeat	197..242	CDD:276965	15/44 (34%)
		Kelch_3	206..255	CDD:404319	16/49 (33%)
		KELCH repeat	251..308	CDD:276965	14/56 (25%)
		Kelch_4	315..371	CDD:404322	9/51 (18%)
		Kelch_2	453..506	CDD:400133
		DUF4110	564..651	CDD:404326
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940