DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12081 and KEL2

DIOPT Version :9

Sequence 1:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_011754.3	Gene:	KEL2 / 853153	SGDID:	S000003470	Length:	882	Species:	Saccharomyces cerevisiae

Alignment Length:	344	Identity:	81/344 - (23%)
Similarity:	150/344 - (43%)	Gaps:	54/344 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 PFQRYGHT---VVAYKDRIYIWGGRNDENLCNTLYCF----DPKTAQWSRPQVTGCLPGARDGHS 132
            ||.||.|:   :|...:||::.||.:|:::...::..    |..:....|..:....|..|.||:
Yeast    82 PFPRYRHSSSFIVTNDNRIFVTGGLHDQSVYGDVWQIAANADGTSFTSKRIDIDQNTPPPRVGHA 146

  Fly   133 ACVIGNSMYIFGGFVDEINE---FSSDVHSLNLDTMEWRYVQTFGVPPSYRDFH--ASVAYE--Q 190
            :.:.||:..:|||...::|:   ...|::..|:::.:|...|..|..|..|..|  :.:|..  |
Yeast   147 STICGNAYVVFGGDTHKLNKNGLLDDDLYLFNINSYKWTIPQPIGRRPLGRYGHKISIIASNPMQ 211

  Fly   191 ERMYIFGGRGDKHSPYHSQEETYCHEIVYLDMKTKVWHRPFT-------AGKVPVGRRSHSMFVY 248
            .::|:|||:.|         |||.:::|..|:.:  :.||.:       .|.:|....:|:|..|
Yeast   212 TKLYLFGGQVD---------ETYFNDLVVFDLSS--FRRPNSHWEFLEPVGDLPPPLTNHTMVAY 265

  Fly   249 NKLIYVFGGYNGLLDQHFNDLYTFDPRTKLWNLIRANGKAPTARRRQCAIVMGTRMFLFGGTSPR 313
            :..::||||.......  ||.|.:||....|:.::..|:.|...:...::|....|.:.||....
Yeast   266 DNKLWVFGGETPKTIS--NDTYRYDPAQSEWSKVKTTGEKPPPIQEHASVVYKHLMCVLGGKDTH 328

  Fly   314 SGSSSSPAAVS---------PTQETGGAAAAGG----------VVPPGVALIDYSDLHVLDFEPT 359
            :..|:....::         |..:.|......|          ::..|....||:..::.|.: |
Yeast   329 NAYSNDVYFLNLLSLKWYKLPRMKEGIPQERSGHSLTLMKNEKLLIMGGDKTDYASPNIHDLQ-T 392

  Fly   360 LKTLATMVVLKHQLDISGL 378
            .:|......|.:.||:|.|
Yeast   393 SETDQGEGTLLYTLDLSSL 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965
		Kelch_6	13..60	CDD:290672
		KELCH repeat	78..125	CDD:276965	11/53 (21%)
		Kelch_1	78..117	CDD:279660	10/45 (22%)
		KELCH repeat	128..170	CDD:276965	12/44 (27%)
		Kelch_3	137..188	CDD:290151	14/55 (25%)
		KELCH repeat	180..236	CDD:276965	17/66 (26%)
		Kelch_3	192..248	CDD:290151	16/62 (26%)
		Kelch_5	237..276	CDD:290565	13/38 (34%)
KEL2	NP_011754.3	Kelch_5	82..116	CDD:404696	11/33 (33%)
		PLN02153	139..379	CDD:177814	58/252 (23%)
		KELCH repeat	142..190	CDD:276965	13/47 (28%)
		KELCH repeat	257..308	CDD:276965	15/52 (29%)
		KELCH repeat	310..353	CDD:276965	6/42 (14%)
		Smc	<603..>882	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343274
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9233
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.830