DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12081 and Hcfc2

DIOPT Version :9

Sequence 1:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_030101101.1	Gene:	Hcfc2 / 67933	MGIID:	1915183	Length:	788	Species:	Mus musculus

Alignment Length:	263	Identity:	79/263 - (30%)
Similarity:	123/263 - (46%)	Gaps:	22/263 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 VPFQRYGHTVVAYKDRIYIWGGRNDENLCNTLYCFDPKTAQWSRPQVTGCLPGARDGHSACVIGN 138
            ||..|:||..||.::.:.|:||.| |.:.:.|:.::..|.||..|.|.|.:|.....|.....|.
Mouse    19 VPRARHGHRAVAIRELMIIFGGGN-EGIADELHVYNTVTNQWFLPAVRGDIPPGCAAHGFVCDGT 82

  Fly   139 SMYIFGGFVDEINEFSSDVHSLNLDTMEWRYVQ----TFGVPPSYRDFHASVAYEQERMYIFGGR 199
            .:.:|||.| |...:|::::.|......|:.|:    ..|.||..|..|:...| ..:.|:|||.
Mouse    83 RILVFGGMV-EYGRYSNELYELQASRWLWKKVKPQPPPSGFPPCPRLGHSFSLY-GNKCYLFGGL 145

  Fly   200 GDKHSPYHSQEETYCHEIVYLDMK----TKVWHRPFTAGKVPVGRRSHSMFVYNK------LIYV 254
            .::....::....|.::...|:::    ...|..|.|.|.||..|.||:..:|.|      .:||
Mouse   146 ANESEDSNNNVPRYLNDFYELELQHGSGVVGWSIPATKGVVPSPRESHTAIIYCKKDSASPKMYV 210

  Fly   255 FGGYNGLLDQHFNDLYTFDPRTKLWNLIRANGKAPTARRRQCAIVMGTRMFLFGGTSPRSGSS-- 317
            |||..|   ...:||:..|..|..|:.....|..|..|....|.|:|.:|::|||..|..|.:
Mouse   211 FGGMCG---ARLDDLWQLDLETMSWSKPETKGTVPLPRSLHTASVIGNKMYIFGGWVPHKGENPE 272

  Fly   318 SSP 320
            :||
Mouse   273 TSP 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965
		Kelch_6	13..60	CDD:290672
		KELCH repeat	78..125	CDD:276965	17/46 (37%)
		Kelch_1	78..117	CDD:279660	14/38 (37%)
		KELCH repeat	128..170	CDD:276965	10/41 (24%)
		Kelch_3	137..188	CDD:290151	15/54 (28%)
		KELCH repeat	180..236	CDD:276965	13/59 (22%)
		Kelch_3	192..248	CDD:290151	15/59 (25%)
		Kelch_5	237..276	CDD:290565	15/44 (34%)
Hcfc2	XP_030101101.1	PLN02193	<2..262	CDD:177844	73/248 (29%)
		KELCH repeat	23..69	CDD:276965	17/46 (37%)
		KELCH repeat	127..186	CDD:276965	13/59 (22%)
		PLN02193	<232..>375	CDD:177844	15/44 (34%)
		KELCH repeat	245..312	CDD:276965	12/31 (39%)
		FN3	<547..601	CDD:238020
		FN3	607..707	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940