DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12081 and si:dkey-3d4.3

DIOPT Version :9

Sequence 1:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	XP_683707.1	Gene:	si:dkey-3d4.3 / 555952	ZFINID:	ZDB-GENE-070912-527	Length:	422	Species:	Danio rerio

Alignment Length:	410	Identity:	90/410 - (21%)
Similarity:	156/410 - (38%)	Gaps:	116/410 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LWTVHLDGGP---QRVNHAAVGVGDFIYSFGG--YCTGYDY-RYNEPIDVHALNAHTMRWTLVPQ 60
            |||......|   .|..||:......:|..||  .|:..|: :||...:         .|..:|.
Zfish     9 LWTPVPQQCPAPCDRYKHASCAHRGHVYLLGGREKCSLRDFWKYNVVCN---------DWVELPC 64

  Fly    61 QLDDAGVPLKYPLVPFQRYGHTVVAYKDRIYIWGGRNDENLCNT---LYCFDPKTAQW-----SR 117
            ..::|         |.:...||:||::..:|::||..|.:..|:   |:.||.....|     :.
Zfish    65 DSEEA---------PEEVEEHTMVAHQGFLYVFGGLRDSSYSNSKTPLWVFDTGKECWINWKAAS 120

  Fly   118 PQVTGCLPGARDGHSACVIGNSMYIFGGFVD---EINEFSSDVHSLNLDTMEWRYVQTFGVPPSY 179
            ..:.|..||.|.||||.::|:||||:||::|   ...||             |::
Zfish   121 VALQGVTPGNRKGHSAVILGSSMYIYGGYIDIKGSTKEF-------------WKF---------- 162

  Fly   180 RDFHASVAYEQERMYIFGGRGDKHSPYHSQEETYCHEIVYLDMKTKVWHRPFTAGKVPVGRRSHS 244
                                                     |.::::|....:|...|..|.|||
Zfish   163 -----------------------------------------DFESRLWSLRSSAQVGPGPRHSHS 186

  Fly   245 MFVYNKLIYVFGGYNGLLDQHFNDLYTFDPRTKLWNLIRANGKAPTARRRQCAIVMGTRMFLFGG 309
            ...:.:.:|::||..||.:|  .||:::...::.|:.|:.: ..|:......|::....:.:|||
Zfish   187 AVTHGEWMYLYGGLQGLREQ--KDLWSWSSASQTWSCIKFH-SGPSRLVGHSAVLFKDSILIFGG 248

  Fly   310 TSPRSGSSSSPAAVSPTQETGGAAAAGGVVP--PGVALIDYSDLHV-----LDFEPTLKTLATMV 367
            ...:|...:|....:...:|...      :|  ||.|.: |...|.     ..|:||.:|.....
Zfish   249 GETQSSPQNSLWKFNLETQTWKK------LPLLPGSASV-YRIHHCSVGLGQSFQPTTQTSIYYR 306

  Fly   368 VLKHQLDISGLPRSFRSDLQ 387
            .:.:..:|....|.|::..|
Zfish   307 EIPNSHNIKNKLRPFKNKCQ 326

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965	13/58 (22%)
		Kelch_6	13..60	CDD:290672	11/49 (22%)
		KELCH repeat	78..125	CDD:276965	14/54 (26%)
		Kelch_1	78..117	CDD:279660	13/46 (28%)
		KELCH repeat	128..170	CDD:276965	16/44 (36%)
		Kelch_3	137..188	CDD:290151	11/53 (21%)
		KELCH repeat	180..236	CDD:276965	3/55 (5%)
		Kelch_3	192..248	CDD:290151	8/55 (15%)
		Kelch_5	237..276	CDD:290565	13/38 (34%)
si:dkey-3d4.3	XP_683707.1	KELCH repeat	23..69	CDD:276965	12/54 (22%)
		Kelch_1	23..63	CDD:279660	11/48 (23%)
		KELCH repeat	73..130	CDD:276965	15/56 (27%)
		Kelch_1	76..113	CDD:279660	12/36 (33%)
		KELCH repeat	131..175	CDD:276965	18/107 (17%)
		Kelch_3	140..188	CDD:290151	19/111 (17%)
		Kelch_5	179..216	CDD:290565	13/38 (34%)
		KELCH repeat	182..228	CDD:276965	14/48 (29%)
		KELCH repeat	231..276	CDD:276965	8/50 (16%)
		Kelch_6	232..276	CDD:290672	8/49 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D933937at2759
OrthoFinder	1	1.000	-	-		FOG0001118
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920