DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12081 and rabepk

DIOPT Version :9

Sequence 1:	NP_001259343.1	Gene:	CG12081 / 31799	FlyBaseID:	FBgn0030053	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_001002209.1	Gene:	rabepk / 431756	ZFINID:	ZDB-GENE-040704-52	Length:	351	Species:	Danio rerio

Alignment Length:	325	Identity:	83/325 - (25%)
Similarity:	129/325 - (39%)	Gaps:	61/325 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DGGPQRVNHAAVGVGDFIYSFGGYCTGYDYRYNEPIDVHALNAHTMRWTLVPQQLDDAGVPLKYP 72
            |||         |.|..:...|...:|      ...|.:.:|..|.:|.|.    |..|:..:|.
Zfish    48 DGG---------GKGKIVIVGGANPSG------SFADSYIINLDTHQWDLP----DWEGLQARYE 93

  Fly    73 LVPFQRYGHTVVAYKDRIYIWGG---RNDENLCNTLYCFDPKTAQ--WSRPQVTGCLPGARDGH- 131
            ...|     |..:....::::||   ..:.|....|...|....:  |...||||..|..|..|
Zfish    94 HCSF-----TPESEPQSLWVFGGAEKSTNRNCVQALRFSDGGEGRRFWQSVQVTGVPPSGRTYHT 153

  Fly   132 -SACVIGNSMYIF-GGFVDEINEFSSDVHSLNLDTMEWRYVQTFGVPPSYRDFHASVAYEQERMY 194
             |||| ||.:::| ||.........:.:|..:..::.|....|.|.||:.|..|...|...: :|
Zfish   154 NSACV-GNRLFVFSGGEAGSSAVTDAQLHVFDAVSVTWTQPDTTGTPPAQRHGHVITAVGSD-IY 216

  Fly   195 IFGG-RGDKHSPYHSQEETYCHEIVYLDMKTKVWHRPFTAGKVPVGRRSHSMFVYNKLIYVFGGY 258
            |.|| .|:|   :||       ::..|:.::..|.:....|.:|.|..:||...:||.|::|||.
Zfish   217 IHGGMSGEK---FHS-------DMFTLNTESLKWQKVKAKGDLPPGVAAHSSVTFNKNIFIFGGM 271

  Fly   259 NGLLDQHFNDLYTFDPRTKLWNLIRANGKAPTAR--RRQCAIVMGTRM------------FLFGG 309
            ..  |...|.::.|....:.|.|::..|..|..|  ...|.:....:|            |:|||
Zfish   272 TA--DGATNSMFKFQCDKQRWTLLKFEGDLPPGRLDHSMCLLPWRVKMEDSEHADVQHLCFVFGG 334

Fly 310 309
Zfish 335 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12081	NP_001259343.1	KELCH repeat	13..69	CDD:276965	11/55 (20%)
		Kelch_6	13..60	CDD:290672	9/46 (20%)
		KELCH repeat	78..125	CDD:276965	11/51 (22%)
		Kelch_1	78..117	CDD:279660	7/43 (16%)
		KELCH repeat	128..170	CDD:276965	13/44 (30%)
		Kelch_3	137..188	CDD:290151	13/51 (25%)
		KELCH repeat	180..236	CDD:276965	14/56 (25%)
		Kelch_3	192..248	CDD:290151	15/56 (27%)
		Kelch_5	237..276	CDD:290565	13/38 (34%)
rabepk	NP_001002209.1	Kelch 1	54..102		12/62 (19%)
		Kelch 2	105..156		13/50 (26%)
		KELCH repeat	149..199	CDD:276965	15/50 (30%)
		Kelch_3	159..211	CDD:290151	13/51 (25%)
		Kelch 3	162..210		11/47 (23%)
		KELCH repeat	203..250	CDD:276965	14/57 (25%)
		Kelch_1	203..243	CDD:279660	13/50 (26%)
		Kelch 4	214..263		15/59 (25%)
		KELCH repeat	253..293	CDD:276965	12/41 (29%)
		Kelch_3	262..311	CDD:290151	15/50 (30%)
		Kelch 5	264..313		13/50 (26%)
		Kelch 6	328..351		4/7 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D933937at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1494
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.950